Comparative study between using QuantiFERON and tuberculin skin test in diagnosis of Mycobacterium tuberculosis infection

Abdel-Samea, Sohair A.; Ismail, Yasser; Fayed, Sahar; Ali, Mohammad

doi:10.1016/j.ejcdt.2013.02.003

Cited by 11 publications

(10 citation statements)

References 33 publications

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“…Hoffmann and Ravn 19 had reported poor or moderate agreement for low-/middle-income regions in Europe. The agreement between TST and QFT was reported as good by in Egypt Abdel-Samea et al 35 Khawcharoenporn et al 36 has reported low concordance between 2 tests. The level of agreement between tests has improved when using a TST cutoff ≥ 10 mm (κ = .39).…”

Section: Discussionmentioning

confidence: 96%

Utility of QuantiFERON-TB Gold In-Tube Test in the Diagnosis of Latent TB in HIV-Positive Patients in a Medium-TB Burden Country

Khazraiyan

Liaei

Koochak

et al. 2015

J Int Assoc Provid AIDS Care

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Background: The authors aimed to compare TST with QuantiFERON-TB Gold In-Tube (QFT) for detecting latent tuberculosis infection (LTBI) in HIV-infected patients in Iran as a TB-medium endemic country. Methods: In a cross-sectional design,130 HIVpositive patients in HIV clinic of Tehran University were studied. Patients screened for LTBI with QFT and TST simultaneously. Concordance between 2 tests results and variables associated with tests discordance were assessed. Results: Positive results found in 24.6% for TST and 7.7% for QFT. Overall agreement between them was 73.85% (Kappa ¼ 0.083). History of imprisonment was associated with more positive TST (P ¼ 0.014) and QFT (P ¼ 0.01). Patients with intravenous drug use (IDU) history had significant discordant results (0.018). Conclusion: The authors recommend QFT for all negative cases of TST in HIV-positive patients especially who had history of IDU.

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Section: Discussionmentioning

confidence: 96%

Utility of QuantiFERON-TB Gold In-Tube Test in the Diagnosis of Latent TB in HIV-Positive Patients in a Medium-TB Burden Country

Khazraiyan

Liaei

Koochak

et al. 2015

J Int Assoc Provid AIDS Care

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“…False-negative results may occur in HIV-infected and immunosuppressed patients as they are unable to mount a satisfactory T-cell response, and their production of IFN- γ is low [ 49 ]. Even though, IGRAs are reported to have higher sensitivity and specificity compared to TST [ 50 , 51 ]. IGRAs is not fully suitable for children under the age of five as insufficient IFN- γ is produced at this age group [ 52 ].…”

Section: Role Of Interferon In Tuberculosismentioning

confidence: 99%

Role of Interferons in the Development of Diagnostics, Vaccines, and Therapy for Tuberculosis

Chin

Anis

Sarmiento

et al. 2017

Journal of Immunology Research

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Tuberculosis (TB) is an airborne infection caused by Mycobacterium tuberculosis (Mtb). About one-third of the world's population is latently infected with TB and 5–15% of them will develop active TB in their lifetime. It is estimated that each case of active TB may cause 10–20 new infections. Host immune response to Mtb is influenced by interferon- (IFN-) signaling pathways, particularly by type I and type II interferons (IFNs). The latter that consists of IFN-γ has been associated with the promotion of Th1 immune response which is associated with protection against TB. Although this aspect remains controversial at present due to the lack of established correlates of protection, currently, there are different prophylactic, diagnostic, and immunotherapeutic approaches in which IFNs play an important role. This review summarizes the main aspects related with the biology of IFNs, mainly associated with TB, as well as presents the main applications of these cytokines related to prophylaxis, diagnosis, and immunotherapy of TB.

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“…Interferon-gamma assay (IGRA) is another screening tool for diagnosing both latent [ 29 ] and active TB infection [ 30 ]. Although a study showed the concordance between TST and IGRA results [ 31 ], the accuracy of TB infection tests trended to improve when using IGRA (i.e., there was a low rate of false positives) [ 16 , 32 ]. IGRA is more reliable than the TST in cases of BCG vaccination because a BCG vaccination does not confound the IGRA [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Skin thickness affects the result of tuberculin skin test in systemic sclerosis

et al. 2022

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Background Skin thickness is a prominent clinical feature of systemic sclerosis (SSc), but there is no consensus on the cut-off for a positive tuberculin skin test (TST) size and the limitation of the TST for a diagnosis of tuberculosis in SSc. We aimed to identify the cut-off size of an indurated TST and the sensitivity and specificity of the test for the diagnosis of tuberculosis in SSc patients. Methods A cross-sectional study of 168 adult Thai SSc patients was conducted. The TST was done using 0.1 ml of purified protein derivatives via intradermal injection. The test was interpreted 72 h after testing. Results The median age was 57.2 years. The majority (71.8%) had the diffuse cutaneous SSc subset. All the patients had a BCG vaccination at birth, and 17 (10.1%) had a tuberculosis infection. An indurated skin reaction size of 20 mm had the highest specificity for tuberculosis (99.3%: 95%CI 96.4–100) (ROC 0.53). The skin thickness—assessed using the modified Rodnan skin score (mRSS)—had a significant negative correlation with the reaction size (Rho -0.23; p = 0.003). Conclusion The TST is not sufficiently sensitive for detecting TB infection in SSc patients, albeit a skin induration of ≥ 15 mm indicates a high specificity for tuberculosis infection. A high mRSS resulted in a smaller skin reaction size when using the TST, which has limited utility as a diagnostic for tuberculosis among SSc patients with severe skin thickness. The manuscript was presented as a poster presentation at the Annual European Congress of Rheumatology EULAR 2019 Madrid 12–15 June 2019. (Ann Rheum Dis. 2019;78(suppl 2): abstract FRI0347) http://dx.doi.org/10.1136/annrheumdis-2019-eular.1456

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Comparative study between using QuantiFERON and tuberculin skin test in diagnosis of Mycobacterium tuberculosis infection

Cited by 11 publications

References 33 publications

Utility of QuantiFERON-TB Gold In-Tube Test in the Diagnosis of Latent TB in HIV-Positive Patients in a Medium-TB Burden Country

Utility of QuantiFERON-TB Gold In-Tube Test in the Diagnosis of Latent TB in HIV-Positive Patients in a Medium-TB Burden Country

Role of Interferons in the Development of Diagnostics, Vaccines, and Therapy for Tuberculosis

Skin thickness affects the result of tuberculin skin test in systemic sclerosis

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