Utility of QuantiFERON-TB Gold In-Tube Test in the Diagnosis of Latent TB in HIV-Positive Patients in a Medium-TB Burden Country

Khazraiyan, Hamideh; Liaei, Z Abdi; Koochak, Hamid Emadi; Ardalan, Farid Azmoudeh; Ahmadinejad, Zahra; Soltani, Ahmad

doi:10.1177/2325957415614645

Cited by 4 publications

(3 citation statements)

References 34 publications

(52 reference statements)

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“…We found the results of the TST and QFT-Plus tests to be in poor agreement (0.225), which is similar to what others have found [31,[33][34][35][36][37][38]. The accuracy measures of the TST are often confounded by BCG vaccination and non-tuberculous mycobacterial (NTM) infections [39], [14].…”

Section: Discussionsupporting

confidence: 75%

Latent tuberculosis infection in HIV-infected adults of Kinshasa, DR Congo

Kadima

Lutumba

Kaswa³

et al. 2019

Preprint

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Background The World Health Organization (WHO) End Tuberculosis Strategy calls for a 90% reduction in tuberculosis (TB) deaths and an 80% reduction in the incidence rate between 2015 and 2035. The 2018 WHO guidelines recognize the need for high-burden countries to implement outreach and treatment for the most vulnerable patients with latent TB infection (LTBI) in addition to treating patients with the active disease. The Democratic Republic of Congo (DR Congo) is among the countries bearing the highest burden of TB. However, additional data on LTBI is required for effective policy and strategy against the disease. Accordingly, the aim of this study is to estimate the prevalence of LTBI in HIV-infected adults in Kinshasa, DR Congo. Methods Over two hundred HIV-infected adult residents of Kinshasa were screened using both TUBERTEST®, which is a tuberculin skin test (TST), and QuantiFERON-TB Gold Plus® (QFT-Plus), which is an interferon gamma release assay. LTBI was screened using TST, QFT-Plus, and a combination of the two tests. The agreement between TST and QFT-Plus was calculated using Cohen’s Kappa coefficient. Results A total of 248 HIV-infected persons were enrolled in the study. Seventy-six patients (30.7% IC 95%: 25.2-36.7) had a positive TST result. Sixty-four (25.8% IC 95%: 20.7-31.6) had a positive QFT-Plus test result. The Kappa coefficient between TST and QFT-Plus was 0.225. Conclusions The prevalence of LTBI among HIV positive adults in Kinshasa was high considering either the positive TST or the positive QFT-Plus. However, the two tests had poor agreement.

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Section: Discussionsupporting

confidence: 75%

Latent tuberculosis infection in HIV-infected adults of Kinshasa, DR Congo

Kadima

Lutumba

Kaswa³

et al. 2019

Preprint

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“…For example, the WHO and official estimates of the prevalence of TB in Saudi Arabia showed a decrease from 86 per 100,000 in 1990 to 55 per 100,000 in 2004 to 10.6 per 100,000 in 2015 compared to global average of 133 per 100,000 (Saudi Ministry of Health, 2015;Al-Hajoj et al, 2013). The observed significant difference in the prevalence of LTBI using TST and QFT-GIT has been reported in several studies (Balkhy et al, 2016;Al Wakeel et al, 2015;Khazraiyan et al, 2016). However, explaining such differences is difficult as both tests do not measure the same components of the immunologic response and the concordance was shown to be only fair to moderate (Ayubi et al, 2015).…”

Section: Discussionmentioning

confidence: 86%

Prevalence of Latent Mycobacterium Tuberculosis Infection (LTBI) in Saudi Arabia; Population based survey

Balkhy

Beltagy

El-Saed

et al. 2017

International Journal of Infectious Diseases

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“…The concordance between TST and QFTGIT was evaluated using a percentage of agreement and kappa (k) coefficient analysis. Strength of agreement was considered 'poor' for k 0.20, 'fair' for 0.20 < k 0.40, 'moderate' for 0.40 < k 0.60, 'good' for 0.60 < k 0.80, and 'excellent' for 0.80 < k 1.00 (Ramos et al, 2012;Khazraiyan et al, 2016). For analysis of the agreement, participants with indeterminate test results were excluded.…”

Section: Discussionmentioning

confidence: 99%

Effect of pregnancy and HIV infection on detection of latent TB infection by Tuberculin Skin Test and QuantiFERON-TB Gold In-Tube assay among women living in a high TB and HIV burden setting

Birku

Desalegn

Kassa

et al. 2020

International Journal of Infectious Diseases

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To investigate the effect of pregnancy and Human immunodeficiency virus (HIV) infection on detection performances of tuberculin skin test (TST) and QuantiFERON-TB Gold In-Tube (QFTGIT) for the diagnosis of latent tuberculosis infection (LTBI) among women living in high TB and HIV endemic setting. Method: A cross-sectional study was conducted among women with and without pregnancy and HIV infection. Three-hundred twenty women were enrolled in this study and were diagnosed using TST and QFTGIT for the detection of LTBI.Results: Overall prevalence of LTBI among the enrolled women was 55.6%, 46.3% and 51.1% as determined by TST, QFTGIT and concordant TST/QFTGIT results, respectively. Our study revealed that pregnancy or HIV infection reduced the rate of detection of LTBI by TST and QFTGIT tests, with the utmost effect observed in HIV-positive pregnant women. Additionally, we observed that the concordance between TST and QFTGIT among women increased with the presence of pregnancy and/or HIV infection. A history of contact with TB patients was significantly associated with positivity of TST and QFTGIT. Conclusion: This study demonstrated that both pregnancy and HIV infection profoundly affected the detection performance of TST and QFTGIT, which may be associated with immunosuppression of antimycobacterial immunity in women with pregnancy and/or HIV infection.

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Utility of QuantiFERON-TB Gold In-Tube Test in the Diagnosis of Latent TB in HIV-Positive Patients in a Medium-TB Burden Country

Cited by 4 publications

References 34 publications

Latent tuberculosis infection in HIV-infected adults of Kinshasa, DR Congo

Latent tuberculosis infection in HIV-infected adults of Kinshasa, DR Congo

Prevalence of Latent Mycobacterium Tuberculosis Infection (LTBI) in Saudi Arabia; Population based survey

Effect of pregnancy and HIV infection on detection of latent TB infection by Tuberculin Skin Test and QuantiFERON-TB Gold In-Tube assay among women living in a high TB and HIV burden setting

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