Comparative study for chiral separation of Atracurium besylate isomers: Eco-friendly HPLC using Lux Cellulose-3 chiral column, and TLC-Densitomerty approaches

Nessiem, Marina A.; Riad, Safa'a M.; Fayed, Ahmed S.; Arafa, Reham M.

doi:10.1016/j.scp.2023.101358

Sustainable Chemistry and Pharmacy

2024

DOI: 10.1016/j.scp.2023.101358

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Comparative study for chiral separation of Atracurium besylate isomers: Eco-friendly HPLC using Lux Cellulose-3 chiral column, and TLC-Densitomerty approaches

Marina A. Nessiem,

Safa'a M. Riad,

Ahmed S. Fayed

et al.

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2024

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Cited by 3 publications

References 25 publications

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Biomedical Potential of Cellulose: Current Trends and Future Directions

Jafari,

Al‐Ostaz,

Nouranian

2024

Polymers for Advanced Techs

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The exploration of cellulose, a natural polysaccharide derived from renewable biomass, has seen significant advancements in recent years due to its biocompatibility, biodegradability, and versatility. This review paper comprehensively covers the latest developments in cellulose and its derivatives as functional biomaterials for various biomedical applications. Emphasis is placed on the intrinsic properties of cellulose, such as its mechanical strength, thermal stability, and chemical modifiability, which enable its wide‐ranging use in drug delivery systems, wound dressings, tissue engineering, and biosensors. The article further delves into the modification techniques—such as oxidation, esterification, and etherification—that enhance cellulose's performance, allowing it to be fine‐tuned for specialized medical applications, including the creation of scaffolds for tissue regeneration and smart materials for responsive drug release. Additionally, the hybridization of cellulose with inorganic materials offers potential in developing materials with superior antimicrobial properties and improved mechanical characteristics. This review also addresses the challenges in cellulose processing, particularly concerning optimizing its structure for specific applications, while highlighting future opportunities in the field of personalized medicine and intelligent healthcare devices. By examining both the current innovations and future trends, this review highlights the growing importance of cellulose as a sustainable and versatile resource in the biomedical industry.

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Biomedical Potential of Cellulose: Current Trends and Future Directions

Jafari,

Al‐Ostaz,

Nouranian

2024

Polymers for Advanced Techs

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Chiral Separation of Racemic Atracurium through β-Cyclodextrin Sulphated Sodium Modified Gold Nanoparticles/Pencil Graphite Electrode: An Eco-Friendly Voltammetric Behavior of Cisatracurium Isomer in Real Samples

Nessiem,

Riad,

Fayed

et al. 2024

J. Electrochem. Soc.

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A novel electrochemical sensor for chiral separation of racemic Atracurium ‎‎(racATR) into its three isomers (cis-cis, cis-trans, trans-trans) was assembled. The sensor was ‎based on immobilization of β-cyclodextrin sulphated sodium salt (S-β-CD) with gold ‎nanoparticles (Au-NPs) on pencil graphite electrode (S-β-CD/Au-NPs/PGE). A significant ‎increase in peak currents of cyclic voltammetry and differential pulse voltammetry ‎was noticed through applying this sensor. This is attributed to the electrochemical sensitivity of ‎Au-NPs along with high chiral discrimination of S-β-CD via the host-guest interaction. The sensor's construction was tested by the electrochemical ‎oxidation behavior of cisatracurium (cisATR) isomer in Britton Robinson buffer (pH=11) ‎at scan rate 30 mV s-1. The peak currents increased proportionally as the cisATR concentration ‎varying between 8.0 ×10–8 - 1.0 ×10–6 M. The correlation coefficient and limit of detection have ‎been demonstrated to be 0.9999 and 8.8 ×10–9, respectively. The analytical applications of S-β-‎CD/Au-NPs/PGE electrode were assessed through the dosage form and human plasma as a real ‎sample. The proposed method was found to be an eco-friendly electrochemical approach ‎according to the four greenness assessment tools: Analytical Eco-Scale, National ‎Environmental Method Index, Green Analytical Procedure Index, and ‎Analytical Greenness metric.

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Rational Design of Selective Electrochemical Sensor for Dexketoprofen Determination in Human Plasma: Application based on Molecularly Imprinted Co-Polymer

Nessiem,

Riad,

Fayed

et al. 2024

J. Electrochem. Soc.

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A simple, repeatable, and inexpensive molecularly imprinted co-polymer (MIP) sensor was fabricated for Dexketoprofen (DKP) determination. One-step electro-polymerization of levodopa (L-dopa) and o-phenylenediamine (oPD) functional monomers onto a pencil graphite electrode (PGE) with DKP as a template molecule has been developed to fabricate Dexketoprofen PGE/MIP (L-Dopa-co-oPD) sensor. Choice of functional monomers was guided by UV-spectrophotometric method to examine the binding interactions between the template and monomers. The fabricated PGE/MIP (L-Dopa-co-oPD) sensor was characterized using X-ray photoelectron spectroscopy, cyclic voltammetry, and electrochemical impedance spectroscopy. By employing differential pulse voltammetry, quantitative measurements of DKP were obtained by measuring the decline of the redox probe signal (ferrocyanide/ferricyanide) in presence of the drug. The results revealed a consistent voltammetric response with a correlation coefficient of 0.9998 with LOD and LOQ to be 4.0 ×10-15 M and 1.2 ×10-4 M, respectively, over a dynamic linearity range of 1.0 ×10-12 M to 1.0 ×10-14 M of DKP. The sensor exhibited great selectivity for the DKP over structurally related and concurrently delivered drugs allowing its application in its pharmaceutical dosage form and in human plasma samples. The proposed technique was assessed by white analytical chemistry via RGB model showing affordable, environmentally friendly, robust, effective, and sustainable analysis of drug samples

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Comparative study for chiral separation of Atracurium besylate isomers: Eco-friendly HPLC using Lux Cellulose-3 chiral column, and TLC-Densitomerty approaches

Cited by 3 publications

References 25 publications

Biomedical Potential of Cellulose: Current Trends and Future Directions

Biomedical Potential of Cellulose: Current Trends and Future Directions

Chiral Separation of Racemic Atracurium through β-Cyclodextrin Sulphated Sodium Modified Gold Nanoparticles/Pencil Graphite Electrode: An Eco-Friendly Voltammetric Behavior of Cisatracurium Isomer in Real Samples

Rational Design of Selective Electrochemical Sensor for Dexketoprofen Determination in Human Plasma: Application based on Molecularly Imprinted Co-Polymer

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