Comparative Study for In-vitro Evaluation of Metronidazole Prepared Using Natural Chitosan from Oyster Shells of Egeria radiata

Abstract

Objective: The present study investigates the capability of preparing metronidazole loaded microspheres employing a natural chitosan extracted from oyster shells of Egeria radiata. Methods: Microspheres were prepared by external gelation technique using tripolyphosphate (TPP) as the cross-linker. The drug to polymer ratio was selected at various levels of polymer-drug quantities with varying amount of TPP. The prepared microspheres were characterized for % yield, drug entrapment efficiency, surface morphology and drug release profile. Results: Almost spherical, rough and porous microspheres were obtained. % yield and drug entrapment efficiency were found to be in the range of 63.5-70.8% and 63.4-77.5% respectively; and about 80% of the drug was released in about 6 hours. Conclusion: The results revealed that formulation of metronidazole loaded microspheres in natural chitosan from an oyster shell can be used as a potential oral drug delivery system.

Preparation of In Situ Cross-Linked N-Maleoyl Chitosan-Oxidized Sodium Alginate Hydrogels for Drug Delivery Applications

“…The cumulative release of MTZ-MCS-OSA hydrogels (H1-H5) at pH 1.2 for 60 min was determined to be 68.68, 63.37, 22.57, 81.66 and 87.50%, respectively. The burst release (burst effect) was exhibited by all hydrogels except MTZ-H3 hydrogel and indicated the release profiles of MTZ-MCS-OSA hydrogels were depended significantly on the composition of MCS and OSA [23], [33], [34], [35]. On the other hand, a more delayed pattern of drug release profiles was obtained for MTZ-H3 hydrogel, and the cumulative release for 1 h in pH 1.2 medium was 22.57%.…”