Comparative study of alpha amylase inhibitory activity of flavonoids of Vitex negundo Linn. and Andrographis paniculata Nees

Gautam, Keerti; Kumar, Puneet; Jain, Chitra

doi:10.4103/0973-8258.111602

Cited by 8 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The positive effect shows in the animals glicemia levels can be reinforced by the alpha amylase inhibition assay, where a 100% inhibition of this enzyme was observed. These results shows that one of the mechanisms of blood glucose reduction that pitaya promotes is through the reduction of digestion and absorption of carbohydrates, which delays the release of glucose to the body, consequently reducing blood glucose (Kazeem et al, 2013;Gautam et al, 2013;Ademiluyi & Oboh, 2013;Zheng et al, 2020). Therefore, as discussed previously, these effects could be related to the quercetin (Najafian, 2015) and the oligossacharides (Wichienchot et al, 2010), both constituints of pitaya.…”

Section: Diabetesmentioning

confidence: 53%

Pitaya [Hylocereus polyrhizus (F.A.C. Weber) Britton & Rose] effect on glycemia and oxidative stress in aloxan-induced diabetic mice

et al. 2023

View full text Add to dashboard Cite

Pitaya is a rich source of bioactive compounds, such as polyphenols and betalains. Moreover, these compounds has been associated with reduced risk of type 2 diabetes mellitus. The aim of this study is to evaluate the effect of this fruit on glycemia and oxidative stress in aloxan-induced diabetic mice. Thus, considering that In the in vivo assays, the mice were divided into 5 groups (n = 6): (a) healthy group treated with water; (b) diabetic mice treated with metformin at 200 mg/kg body weight diluted in water; (c) untreated diabetic mice; (d) diabetic mice treated with pitaya at 200 mg/kg and (e) diabetic mice treated with pitaya at 400 mg/kg of body weight diluted in water. The results shows that pitaya was able significantly to reduce blood glucose (p < 0.05) (200 mg/kg); significantly reduce cholesterol (200 and 400 mg/kg) and significantly increase HDL-c (400 mg/kg) levels. In the oxidative stress experiment, Malondialdehyde levels in the liver were significantly reduced (p < 0.05) in the groups treated with pitaya, when compared to the other groups, suggesting lower lipid peroxidation. The consumption of pitaya reduced the blood glucose and cholesterol and increase the HDL, in addition, the lipid peroxidation -which is common in diabetic patients, was reduced.

show abstract

Section: Diabetesmentioning

confidence: 53%

Pitaya [Hylocereus polyrhizus (F.A.C. Weber) Britton & Rose] effect on glycemia and oxidative stress in aloxan-induced diabetic mice

et al. 2023

View full text Add to dashboard Cite

show abstract

“…It also acts as phytoestrogen and inhibits carbofuran‐induced toxicity as reported in virgin Wister rats (Elfahmi et al , ; Islam et al , ; Parmar et al , ; Dhongade and Chandewar, ). Lintetralin exhibits anti‐hepatitis and anti‐diabetic activity (Gautam et al , ). Phyltetralin displays anti‐hyperuricaemic, anti‐hepatotoxic, anti‐diabetic and anti‐hepatitis activity, while urinatetralin is vasorelaxant in nature and inhibits platelet aggregation (Okoli et al , ; Gautam et al , ).…”

Section: Phytoconstituents and Their Therapeutic Uses In Phyllanthus mentioning

confidence: 99%

“…Lintetralin exhibits anti‐hepatitis and anti‐diabetic activity (Gautam et al , ). Phyltetralin displays anti‐hyperuricaemic, anti‐hepatotoxic, anti‐diabetic and anti‐hepatitis activity, while urinatetralin is vasorelaxant in nature and inhibits platelet aggregation (Okoli et al , ; Gautam et al , ). Cubebin dimethyl ether, niranthin, phyllanthin, secoisolariciresinol, secoisolariciresinol trimethyl ether and secoisolariciresinol‐di‐ O ‐glucoside are dibenzylbutanes having anti‐HBV, antiinflammatory, anti‐allodynamic, anti‐genotoxic, anti‐human immunodeficiency virus (HIV), hepatoprotective, antioxidant, anticancerous and antimicrobial activity (Row et al , ; Sagar et al , ; Kassuya et al , ; Elfahmi et al , ; Krithika et al , ; Xia et al , ; Ayella et al , ; Parmar et al , ; Moree and Rajesha, ; Dhongade and Chandewar, ; Esperandim et al , ).…”

Section: Phytoconstituents and Their Therapeutic Uses In Phyllanthus mentioning

confidence: 99%

Phytochemistry and Pharmacology ofPhyllanthus niruriL.: A Review

Kaur

Sirhindi

2017

Phytotherapy Research

View full text Add to dashboard Cite

Phyllanthus niruri, a typical member of family Euphorbiaceae, is a small annual herb found throughout the tropical and subtropical regions of both hemispheres. The genus Phyllanthus has been used in traditional medicine for its wide range of pharmacological activities like antimicrobial, antioxidant, anticancer, antiinflammatory, antiplasmodial, antiviral, diuretic and hepatoprotective. This review summarizes the information about morphological, biochemical, ethanobotanical, pharmacological, biological and toxicological activities with special emphasis on mechanism of anticancer activity of P. niruri. Gaps in previous studies such as taxonomic inconsistency of P. niruri, novel phytochemicals and their therapeutic properties, especially mechanisms of anticancerous activity and market products available, have been looked into and addressed. Scientific information related to 83 phytochemicals (including many novel compounds detected recently by the authors) has been provided in a very comprehensive manner. Copyright © 2017 John Wiley & Sons, Ltd.

show abstract

“…The isolated compounds were tested for their antidiabetic potential in-vitro by inhibition of the αamylase enzyme. Whereas for plant Andrographis paniculata, flavonoid extracts of the leaf have shown the tremendous alpha-amylase inhibitory effect of 62.22% at 1.5 mg/ml concentration, with a very low IC 50 value of 0.004 mg/ml (P≤0.05) was reported 27 .…”

mentioning

confidence: 99%

Untitled

2019

IJPSR

View full text Add to dashboard Cite

In the present study the 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one isolated from the methanolic extract of leaves of Andrographis echioides was studied for alpha-amylase and alpha-glucosidase inhibition using an in-vitro model. The isolation was done using column chromatography using gradient elution with different mobile phase. Structural elucidation was carried out on the basis of spectral analysis. The study revealed that the 2-(3,4-dihydroxyphenyl)-3,5,7trihydroxy-4H-chromen-4-one exhibited significant α-amylase and α-glucosidase inhibitory activities with an IC 50 value of 36.2 ± 0.42 and 41.4 ± 0.34% respectively and well compared with standard acarbose drug. The infra-red spectrum specific absorption bands for 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H

show abstract

Comparative study of alpha amylase inhibitory activity of flavonoids of Vitex negundo Linn. and Andrographis paniculata Nees

Cited by 8 publications

References 0 publications

Pitaya [Hylocereus polyrhizus (F.A.C. Weber) Britton & Rose] effect on glycemia and oxidative stress in aloxan-induced diabetic mice

Pitaya [Hylocereus polyrhizus (F.A.C. Weber) Britton & Rose] effect on glycemia and oxidative stress in aloxan-induced diabetic mice

Phytochemistry and Pharmacology ofPhyllanthus niruriL.: A Review

Untitled

Contact Info

Product

Resources

About