Comparative study of anatomical normalization errors in SPM and 3D-SSP using digital brain phantom

Onishi, Hideo; Matsutake, Yuki; Kawashima, Hiroki; Matsutomo, Norikazu; Amijima, Hizuru

doi:10.1007/s12149-010-0448-9

Cited by 6 publications

(5 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To minimize the deviation errors caused by analysis software packages, 3D-SSP and eZIP image-processing programs were applied in the same CT attenuation-corrected SPECT images data of MDD patients and normal controls. According to previous studies [ 24 , 25 ], the difference between 3D-SSP and eZIP lies in smoothing process after anatomic standardization. The smoothing process by eZIP is based on an SPM algorithm and effectively enhances the signal-noise ratio of images, which might overestimate cerebral hypoperfusion [ 24 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

“…According to previous studies [ 24 , 25 ], the difference between 3D-SSP and eZIP lies in smoothing process after anatomic standardization. The smoothing process by eZIP is based on an SPM algorithm and effectively enhances the signal-noise ratio of images, which might overestimate cerebral hypoperfusion [ 24 , 25 ]. So we apply corrections for multiple comparisons based on family-wise error (FEW), and P FWE-corr < 0.05 is considered statistically significant in eZIP analysis.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Towards characterizing the regional cerebral perfusion in evaluating the severity of major depression disorder with SPECT/CT

Li¹,

Yang²,

Zhu³

et al. 2018

BMC Psychiatry

View full text Add to dashboard Cite

BackgroundMajor depressive disorder (MDD) is a common mental disorder worldwide, but now there is a lack of clinically effective assessment and management of MDD. In this study, we used technetium-99 m ethylcysteinate dimer ([99mTc]ECD) SPECT/CT to characterize the regional cerebral blood flow (rCBF) status of MDD patients, and to explore an objective image assessment model of MDD which is non- or minimally-invasive, convenient and accurate in a clinical setting.MethodsThe severity of MDD was assessed by three trained psychiatrists, based on scores obtained from HAMD and HAMA. [99mTc]ECD rCBF SPECT/CT was performed in 20 healthy controls and 74 unipolar MDD patients before receiving the treatment. The CT attenuation-corrected SPECT images data were automatically registered, analyzed simultaneously by 3D-SSP and eZIS.ResultsThe mean score of HAMD and HAMA in the MDD patients was 25.49 ± 6.00, and 23.12 ± 5.83, respectively. There was a positive correlation between two scores. The MDD women had higher HAMD scores than MDD men. The decreased rCBF of MDD patients in frontal lobes (bilateral B11, B47 and right B4, B6, B10, B46), temporal lobe (right B21, B41, B42) and cingulated cortex (bilateral B24, B33), while their increased rCBF in occipital lobe (bilateral B17, B19 and left B18). Additionally, the depression severity was negatively correlated with decreased rCBF in left ventral anterior cingulate cortex B24, and was positively correlated with decreased rCBF in left inferior prefrontal gyrus B47 and increased rCBF in right associative visual cortex B19. The anxiety severity was negatively correlated with decreased rCBF in left subgenual cortex B25.ConclusionsAlthough the mechanism underlying the correlation is not yet fully understood, our findings indicated that the rCBF SPECT/CT may provide an objective assessment for MDD severity. It might be used monitoring therapeutic efficacy in the management of MDD.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Towards characterizing the regional cerebral perfusion in evaluating the severity of major depression disorder with SPECT/CT

Li¹,

Yang²,

Zhu³

et al. 2018

BMC Psychiatry

View full text Add to dashboard Cite

show abstract

“…Another problem with Method 2 is the possible creation of errors by misregistration of amyloid images. While the reason for this is not clear, it has been reported that standardization by 3D-SSP was not accurate enough at a head tilt of approximately 25°or more [20]. It is thus important to check each image after registration and AS.…”

Section: Discussionmentioning

confidence: 99%

A modified method of 3D-SSP analysis for amyloid PET imaging using [11C]BF-227

et al. 2011

View full text Add to dashboard Cite

show abstract

“…All SPECT images were analyzed using AZE Virtual Place HAYABUSA software (Canon Medical Systems), and 3-dimensional stereotactic surface projection analysis was performed. To avoid anatomic standardization errors, the head tilt was adjusted to the anterior commissure-posterior commissure line (19,20). Counts of 37 brain regions were measured using volume-of-interest templates incorporated into the 3-dimensional stereotactic surface projection on anatomically standardized SPECT images.…”

Section: Discussionmentioning

confidence: 99%

Optimization of the Attenuation Coefficient for Chang Attenuation Correction in¹²³I Brain Perfusion SPECT

Murata

Hayashi

Onoguchi

et al. 2023

J. Nucl. Med. Technol.

View full text Add to dashboard Cite

N-isopropyl-p-123 I-iodoamphetamine brain perfusion SPECT has been used with various attenuation coefficients (m-values); however, optimization is required. This study aimed to determine the optimal m-value (m opt -value) for Chang attenuation correction (AC) using clinical data by comparing the Chang method and CT-based AC. Methods: We used 100 patients (reference group, 60; disease group, 40) who underwent N-isopropyl-p-123 I-iodoamphetamine SPECT. SPECT images of the reference group were obtained to calculate the AC using the Chang method (m-values, 0.07-0.20; 0.005 interval) and the CT-based method, both without scatter correction (SC) and with SC. The m opt -value with the smallest mean percentage error for the brain regions of the reference group was calculated. Agreement between the Chang and CT-based methods applying the m opt -value was evaluated using Bland-Altman analysis. Additionally, the percentage error in the region of hypoperfusion in the diseased group was compared with the percentage error in the same region in the reference group when the m opt -value was applied. Results: The m opt -values were 0.140 for Chang without SC and 0.160 for Chang with SC. In the Chang method, with the m opt -value applied, fixed and proportional biases were observed in the Bland-Altman analysis (both P , 0.05), and there was a tendency for the percentage error to be underestimated in the limbic regions and overestimated in the central brain regions. There was no significant difference between the disease group and the reference group in the region of hypoperfusion in either Chang without SC or Chang with SC. Conclusion: The present study revealed that the m opt -values of the Chang method are 0.140 without SC and 0.160 with SC.

show abstract

Comparative study of anatomical normalization errors in SPM and 3D-SSP using digital brain phantom

Abstract: When required to evaluate regions with decreased perfusion due to such causes as hemodynamic cerebral ischemia, the 3D-SSP is desirable. In a statistical image analysis, we must reconfirm the image after anatomical standardization by all means.

Cited by 6 publications

References 18 publications

Towards characterizing the regional cerebral perfusion in evaluating the severity of major depression disorder with SPECT/CT

Towards characterizing the regional cerebral perfusion in evaluating the severity of major depression disorder with SPECT/CT

A modified method of 3D-SSP analysis for amyloid PET imaging using [11C]BF-227

Optimization of the Attenuation Coefficient for Chang Attenuation Correction in¹²³I Brain Perfusion SPECT

Contact Info

Product

Resources

About

Comparative study of anatomical normalization errors in SPM and 3D-SSP using digital brain phantom

Abstract: When required to evaluate regions with decreased perfusion due to such causes as hemodynamic cerebral ischemia, the 3D-SSP is desirable. In a statistical image analysis, we must reconfirm the image after anatomical standardization by all means.

Cited by 6 publications

References 18 publications

Towards characterizing the regional cerebral perfusion in evaluating the severity of major depression disorder with SPECT/CT

Towards characterizing the regional cerebral perfusion in evaluating the severity of major depression disorder with SPECT/CT

A modified method of 3D-SSP analysis for amyloid PET imaging using [11C]BF-227

Optimization of the Attenuation Coefficient for Chang Attenuation Correction in123I Brain Perfusion SPECT

Contact Info

Product

Resources

About

Optimization of the Attenuation Coefficient for Chang Attenuation Correction in¹²³I Brain Perfusion SPECT