Comparative Study of Bone Marrow Aspiration and Bone Marrow Trephine Biopsy in Haematological and Non-Haematological Disorders

Abstract

Background: This study was conducted in the Department of Pathology, GMC Patiala on 100 patients over period of three years with the objective to study the comparison of the bone marrow aspiration and bone marrow trephine biopsy in haematological and non-haematological disorders in elderly age patients.(Age >50years). Methods: 100 cases with different hematological and non-hematological problems were taken up for the present study with age >50 years. Salah"s bone marrow aspiration needle and Jamshidi's bone marrow biopsy needle were used to collect the samples. For staining Leishmann's and H&E stains were used. Results: Majority of the cases were in the age of 50-60. Majority of haematological disorders comprised of anaemia (62%), leukemia(17.7%), multiple myeloma (7.5%), primary myelofibrosis(2.5%), myeloproliferative disorders(2.5%), hypocellular marrow (2.5%), increased eoisinophils and precurcors(1.2%), NHL (1.2%) lymphocytosis(1.2%) and plasmacytosis (1.2%). Both of the 2 cases of nonhaematological disorders were of metastatic carcinomatous deposists. Conclusion: The bone marrow aspiration and trephine biopsy were comparative in most of the haematological disorders except in primary and secondary myelofibrosis where biopsy provided clue to the diagnosis. Non-haematological disorders showed the same findings.

Study of Spectrum of Lesions in Bone Marrow Aspiration and Trephine Biopsy from a Tertiary Care Centre in South India

“…The number of male patients in the present study were 63% and the female patients were 37% with a male to female ratio of 1.7:1. This was in concordance with the studies done by Goyal, et al [5], Panigrahi, et al [6], Khan, et al [7], Atchyuta, et al [9], and Birare, et al [10].…”

“…The majority of cases encountered were haematological disorders accounting for 92% followed by 6% of nonhaematological disorders and 2% were normal bone marrow. These findings were in concordance with various studies by Mahajan, et al [3], Khatik, et al [4] and Goyal, et al [5]. The age range was between 9 to 2020.…”

“…Plasma cell disorders were encountered in 23.91% of cases. The most common disorder observed was Multiple myeloma (MM) with 86.35% of cases, followed by 4.55% of cases each of Plasma cell leukaemia (PCL), Walder strom macroglobunemia (WM) and Monoclonal gammopathy of undetermined significance (MGUS), which was in concordance with the studies by Atchyuta, The p-value of bone marrow aspiration and biopsy in relation to diagnosis is significant statistical, the p-value < 0.001 by chi-square method which was comparable with Goyal, et al [5], Bashir, et al [11], and Chauhan, et al [17].…”