Comparative study of effect of intra-operative administration of ringer’s lactate, sterofundin, plasmalyte-A and kabilyte on ionic and acid base status

Comparison of Balanced Crystalloid Solutions: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

“…The balanced crystalloids that were studied include Plasmalyte (Plasma-Lyte 148/Plasma-Lyte A), Kabilyte, Normosol-R, Ringer’s Lactate, Ringerfundin/Ringer’s Acetate, Hartmann’s solution, Ringer’s Bicarbonate, Sterofundin, and novel balanced solutions (see Table 2 for a summary of commercially available fluids and their electrolyte concentrations). Of the included studies, 16 were performed in the perioperative setting ( n = 1142 participants) ( 16 – 20 , 23 , 25 , 26 , 28 , 30 – 32 , 35 , 36 , 38 , 39 ), six in the ICU ( n = 427 participants) ( 21 , 27 , 29 , 33 , 34 , 37 ), one in the emergency department (ED; n = 90 participants) ( 24 ), and one in healthy volunteers ( n = 14 participants) ( 22 ). Five studies involved pediatric patients ( n = 298 participants) ( 16 , 17 , 25 , 38 , 39 ), whereas the remainder focused on adult participants.…”

Evaluation of the metabolic profile of ringer lactate versus ringer acetate in nondiabetic patients undergoing major surgeries

“…This was also noticed by Kumar et al . [ 5 ] in their study where progressively higher blood glucose was noticed in the Kabilyte group. Acetate has a role in carbohydrate and fat metabolism and can rarely cause a slight increase in glucose level.…”

Lactate versus acetate buffered intravenous crystalloid solutions: a scoping review

“…30e32,36e38, 40,48 In the remaining four studies, divergent differences were reported between groups, with two studies favouring acetate-buffered solutions and two studies favouring lactate-buffered solutions. 20,21,24,25 The overall quality of evidence was low and downgraded because of risk of bias and imprecision (Supplementary material E).…”

“…Renal function was assessed in five studies, 20,25,29,38,41 amongst which a majority found no significant differences between groups. 20,25,29,38 Liver function was assessed by 10 studies, 26,27,30,35e39,41,48 with results indicating a possible association between administration of lactate-buffered solutions and a transiently decreased liver function.…”

“…Renal function was assessed in five studies, 20,25,29,38,41 amongst which a majority found no significant differences between groups. 20,25,29,38 Liver function was assessed by 10 studies, 26,27,30,35e39,41,48 with results indicating a possible association between administration of lactate-buffered solutions and a transiently decreased liver function. 27,36,37 The overall quality of evidence describing renal and liver function was very low and downgraded because of risk of bias, indirectness, and imprecision (Supplementary material E).…”