Comparative study of in-vitro antimicrobial activity and phytochemical composition of &amp;lt;i&amp;gt;Sida cuneifolia&amp;lt;/i&amp;gt; fruits, leaves, and stem bark extracts

Nalubega, Rebecca; Nyanzi, Steven A.; Nakavuma, Jesca

doi:10.5455/2319-2003.ijbcp20141023

Cited by 3 publications

(3 citation statements)

References 17 publications

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“…This disparity, can be attributed to the solvent's polarity, highlighting the influence of solvent nature on the extracted compounds. Similar differences were noted in preliminary phytochemical studies on Sida cuneifolia leaves by Nalubega, Nyanzi, and Nakavuma, Kipng'etich et al [9,10].…”

Section: Discussionsupporting

confidence: 82%

“…[22][23][24][25][26]. Sida cuneifolia Apical leaves are used in folk medicine to manage inflammatory by topical application [9,27].…”

Section: Discussionmentioning

confidence: 99%

“…Despite existing studies on antibacterial, antifungal activity, and phytochemical analysis of Sida cuneifolia leaves, there is a notable absence of information regarding the antiinflammatory properties of the specific plant part known as the 'Apical leaves,' commonly used in herbal preparations [9,10]. This study is designed to address this gap by evaluating the antiinflammatory activity specifically in the Apical leaves of Sida cuneifolia.…”

Section: Introductionmentioning

confidence: 99%

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Comparative Evaluation of the Anti-Inflammatory Properties of Methanol and Aqueous Crude Extracts of Apical leaves of Sida cuneifolia: An Ethnomedicinal Plant

Kambugu,

Abdelgadir,

Sesaazi

2023

JOCAMR

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Aims: This study aimed to assess and compare the yield, phytochemical compositions, and anti-inflammatory properties of methanol and aqueous crude extracts derived from the Apical leaves of Sida cuneifolia. Study Design: An analytical study design was employed to evaluate yield and phytochemical composition, while an experimental study design was utilized for anti-inflammatory evaluation studies. Place and Duration of Study: The study was conducted at Mbarara University of Science and Technology, specifically in the Department of Pharmacy Laboratory, spanning from August 2022 to September 2023. Methodology: The extraction yields were determined, and phytochemical profiling conducted to establish the composition of the extracts. Acute dermal toxicity was assessed to determine s. cuneifolia ointment toxicity level using OECD guidelines No. 402. Anti-inflammatory activities were evaluated using the HRBC membrane stabilization model and carrageenan-induced paw inflammatory model in-vitro and in-vivo, respectively. Results: The aqueous extract exhibited a higher percentage yield (10.1%) compared to the methanol extract (4.7%). The methanol extract contained alkaloids, phenolic compounds, steroids, tannins, and cardiac glycosides, while alkaloids and cardiac glycosides were absent in the aqueous extract. Methanol and aqueous extracts, at different concentrations of (0.5, 1.0, 2.0 mg/mL), showed dose-dependent significant stabilization towards HRBC membranes of (54.6%, 59.9%, 66.5%), and (3.85%, 12.57%, 17.10%), respectively. The percentage of protection for the concentration of the methanol extract at 2.0 mg/mL was the highest (66.5%) among the extract dose levels but lower than that of the standard (76.66%). Sida cuneifolia ointment dose levels of (0.5%, 2.5%, and 5.0%) w/w demonstrated significant (P=0.05) reductions in mice paw volume, with percentage inhibitions of (86.33%, 91.4%, and 91.4%). Dose levels (2.5% and 5%) w/w exhibited more potent activity of (91.4%) compared to that of the reference standard, Diclofenac gel 0.1% w/w. (79.41%). Both dose levels of extract ointments (2.5% and 5.0%) w/w exhibited identical levels of percentage inhibition (91.3%) at the end of 4 hours. Conclusion: This study provides scientific evidence supporting the ethno-medicinal use of Apical leaves of Sida cuneifolia, suggesting its potential transformative development in ethnomedicine.

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Section: Discussionsupporting

confidence: 82%

“…[22][23][24][25][26]. Sida cuneifolia Apical leaves are used in folk medicine to manage inflammatory by topical application [9,27].…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Comparative Evaluation of the Anti-Inflammatory Properties of Methanol and Aqueous Crude Extracts of Apical leaves of Sida cuneifolia: An Ethnomedicinal Plant

Kambugu,

Abdelgadir,

Sesaazi

2023

JOCAMR

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Non-volatile Chemical Composition and Botanical Extracts from Lippia javanica (Burm. F) Spreng. In Control of Cowpea Aphids

Wafula¹,

Mutisya²,

Malombe³

2019

J. of Applied Sciences

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Preliminary Phytochemical Analysis of Sida angustifolia Mill., Plant Specimen from Malvaceae Family

Dafare

Gadpayale²

2021

IJARSCT

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The present research paper represents the preliminary phytochemical screening of the crude extract of Sida angustifolia Mill., plant belongs to the Malvaceae family exposed to find out the presence of various bioactive components. The specimen shows the occurrence of Alkaloids, Flavonoids, Phytosterols, Carbohydrate, Phenolic compounds and Tannins mostly while Glycosides, Saponins, Proteins and Free Amino Acids and Gums and mucilage in trace amount. The diversity of phytochemicals found suggests that Sida angustifolia Mill., could serve as a source of useful drugs for future.

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Comparative study of in-vitro antimicrobial activity and phytochemical composition of <i>Sida cuneifolia</i> fruits, leaves, and stem bark extracts

Cited by 3 publications

References 17 publications

Comparative Evaluation of the Anti-Inflammatory Properties of Methanol and Aqueous Crude Extracts of Apical leaves of Sida cuneifolia: An Ethnomedicinal Plant

Comparative Evaluation of the Anti-Inflammatory Properties of Methanol and Aqueous Crude Extracts of Apical leaves of Sida cuneifolia: An Ethnomedicinal Plant

Non-volatile Chemical Composition and Botanical Extracts from Lippia javanica (Burm. F) Spreng. In Control of Cowpea Aphids

Preliminary Phytochemical Analysis of Sida angustifolia Mill., Plant Specimen from Malvaceae Family

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