Comparative study of isobaric levobupivacaine and hyperbaric bupivacaine for subarachnoid block in elective cesarean sections

Rao, Dinesh Govinda; Anand, Shalini G.; Pasha, Nayaz

doi:10.35975/apic.v24i2.1258

Cited by 5 publications

(4 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Rao et al [26] hypotension described in 7 of 30 patients in group with 8mg bupivacaine combined with 25µg fentanyl. Malhotra et al [27] the highest incidence of hypotension had in group with 12,5mg of bupivacaine combined with 25µg fentanyl.…”

Section: Discussionmentioning

confidence: 99%

Comparative analysis of effects of three different doses of fentanyl and standard dose of bupivacaine on a spinal block in patients with hip endoprosthesis surgery

Jović¹,

Janković

Videnović³

et al. 2021

Srp Arh Celok Lek

View full text Add to dashboard Cite

Introduction/Objective. Spinal anesthesia is often used for hip endoprosthesis surgery. Significant surgical stress response consisting of hormonal, metabolic and inflammatory changes can be initiated by the hip replacement surgery. Intrathecal opioids, as adjuvants to local anesthetics, make spinal block sufficient even with lower doses of the local anesthetics, and the incidence of the side effects reduce to minimum. Methods. This study included 162 patients of either sex, ASA 1- 2, scheduled for total hip arthroplasty. The patients had spinal anesthesia with 10mg of 0.5% bupivacaine with 20 ?g (Group I), or 25 ?g (Group II) or 30?g fentanyl intrathecally (Group III). Results. Mean time to achieve maximum motor and sensory blockade was with no significant difference among the groups. Time of motor block duration was shorter in the Group III. Four hours after the operation, patients in the Group I had significantly higher cortisol serum levels. Blood glucose levels were with no significant difference among the groups. Levels of CRP increased remarkably postoperatively in the Group I. Incidence of hypotension, bradycardia, nausea and vomiting was significantly higher in the Group III. Pruritus and shevering were not recorded among the groups. The first time an analgetic was needed postoperatively was the longest in the Group III. Conclusion. The dose of 10mg of bupivacaine combined with 25 ?g fentanyl was the optimal option to achieve hemodynamic stability, sufficient sensory and motor blockade, and reduce the stress response and incidence of the opioids side effects such as vomiting, nausea, pruritus etc.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparative analysis of effects of three different doses of fentanyl and standard dose of bupivacaine on a spinal block in patients with hip endoprosthesis surgery

Jović¹,

Janković

Videnović³

et al. 2021

Srp Arh Celok Lek

View full text Add to dashboard Cite

show abstract

“…Literatürde motor blokların başlama ve sonlanması ile ilgili farklı sonuçlar rapor edilmiştir. Bizim çalışmamızın aksine bir çalışmada motor blokajın izobarik grupta daha erken sonlandığı rapor edilmiştir (21). İzobarik grupta, hiperbarik hastalığa göre daha hızlı motor blok başlangıcı ve daha uzun etki süresi rapor eden çalışmalar da mevcuttur (22,23).…”

Section: Discussionunclassified

Spinal Anestezi ile Sezaryen Doğumda İzobarik Bupivakain ile Hiperbarik Bupivakain Kullanımının Değerlendirilmesi

Kepekçi¹

2020

JMS

View full text Add to dashboard Cite

Spinal anestezi (SA) sezaryen doğum (SD) hastalarında yaygın olarak kullanılmaktadır. SA uygulamasının birçok avantajının yanında dezavantajları da vardır. Olası komplikasyonları en aza indirmek için farklı SA prosedürleri geliştirilmiştir. Bu çalışmada SA ile SD uygulanan gebelerde, bupivakainin farklı barisite çeşitlerinin olası komplikasyonlar ve blok seviyesi üzerine etkileri karşılaştırıldı. 1 Ocak-28 Şubat 2020 tarihleri arasında elektif SD yapan anneleri kapsayan prospektif bir çalışma planlandı. Bir gruba izobarik bupivakain, diğerine maternal etkilerini gözlemlemek için hiperbarik bupivakain uygulandı. SA sonrası hemodinamik değişiklikler, duyusal ve motor blok seviyeleri karşılaştırıldı. Katılımcılar kapalı zarf yöntemi ile randomize edilerek seçildi. Veri analizi SPSS (versiyon 23) kullanılarak İstatistiksel karşılaştırmalar için Binom Testi, Mann-Whitney U-testi ve ki-kare testi kullanıldı. Tüm testler için p <0,05 değeri istatistiksel olarak anlamlı kabul edildi. İzobarik grupta (%74) hipotansiyon insidansının hiperbarik gruptan (%56) daha yüksek olduğu bulundu (p = 0.046). Başlangıçta ortalama kan basıncı değerinde istatistiksel olarak anlamlı bir fark bulunmadı, ancak SA sonrası tüm çalışma zamanlamasında 30.dakika dışında gruplar arasında istatistiksel olarak anlamlı değişiklikler gözlendi (sırasıyla p=0.037, p=0.045, p=0.012, p=0.043, p=0.017, p=0.155). Kalp hızı değişkenliğinde tüm dönemlerde istatistiksel olarak anlamlı bir fark gözlenmedi (p> 0.05). İzobarik grupta 14 (%28) hiperbarik gruba 5 (%10) hastada efedrin kullanıldı (p=0,020). Çalışmamızda izobarik grupta daha yüksek düzeyde duyusal blokaj saptandı (p=0,045). Ama duyusal bloğun T12'ye gerilemesi hiperbarik grubunda anlamlı olarak daha erken idi (p=0.017). Motor bloğun sonlanma süresi açısından ise grupları arasında anlamlı bir fark gözlenmedi (p=0,156). SD için SA uygulanan hastalarda hiperbarik bupivakain daha az hipotansiyona sebep olması ile avantaj sağlarken, izobarik bupivakain daha uzun motor ve duyusal blok sağlar.

show abstract

“…Cesarean section is one of the most common surgeries in obstetrics, the rate of which is increasing significantly worldwide (1)(2)(3)(4). The rate of cesarean section has been reported at 42.35% in the world and 47.9% in Iran (5,6).…”

Section: Contextmentioning

confidence: 99%

A Comparative Study on the Effect of Intrathecal Bupivacaine vs. Ropivacaine on Maternal and Neonatal Outcomes After Cesarean Section: A Systematic Review and Meta-analysis

et al. 2023

View full text Add to dashboard Cite

Context: The type of anesthesia in cesarean section can affect the mother and baby. This study aimed to determine the comparative effect of intrathecal hyperbaric bupivacaine vs. hyperbaric ropivacaine on maternal and neonatal outcomes after cesarean section. Evidence Acquisition: PubMed, Web of Science, Embase, Google Scholar, IranDoc, MagIran, and Scopus databases were searched from 1 September 2022 to 1 November 2022. Eighteen clinical trials with 1542 patients were included in the analysis. Results: There was no statistically significant difference in hypotension, bradycardia, and Apgar score between the 2 groups (P > 0.05). The risk of nausea (relative risk (RR), 1.526; 95% CI, 1.175 - 1.981; P = 0.001) and vomiting (RR, 1.542; 95% CI, 1.048 - 2.268; P = 0.02) caused by bupivacaine was 0.53% and 0.54% higher than that of ropivacaine. The incidence of shivering (RR, 2.24; 95% CI, 1.480 - 3.39; P = 0.00) was 2.24 times higher in the bupivacaine group than in the ropivacaine group. The average onset time of sensory block (standardized mean difference (SMD), -0.550; 95% CI, -1.054 to -0.045; P = 0.032) and motor block (SMD, -0.812; 95% CI, -1.254 to -0.371; P = 0.000) was significantly lower in the bupivacaine group than in the ropivacaine group. Conclusions: Despite the fact that ropivacaine and bupivacaine are effective in cesarean section, ropivacaine is more favorable because of less hemodynamic changes, less duration of sensory and motor block, and fewer side effects, which are effective in patient recovery.

show abstract

Comparative study of isobaric levobupivacaine and hyperbaric bupivacaine for subarachnoid block in elective cesarean sections

Cited by 5 publications

References 16 publications

Comparative analysis of effects of three different doses of fentanyl and standard dose of bupivacaine on a spinal block in patients with hip endoprosthesis surgery

Comparative analysis of effects of three different doses of fentanyl and standard dose of bupivacaine on a spinal block in patients with hip endoprosthesis surgery

Spinal Anestezi ile Sezaryen Doğumda İzobarik Bupivakain ile Hiperbarik Bupivakain Kullanımının Değerlendirilmesi

A Comparative Study on the Effect of Intrathecal Bupivacaine vs. Ropivacaine on Maternal and Neonatal Outcomes After Cesarean Section: A Systematic Review and Meta-analysis

Contact Info

Product

Resources

About