Comparative study of isoflurane and ketamine anesthetics in Rabbits

Khan, Ahmed Nawaz Tunio Muhammad Ali; Ahmad, Abrar; Kachiwal, Mool Chand Malhi Allah Baksh; Khan, Asad; Qasim, Muhammad; Said, Arsalan; Khan, Rahat-Ullah; Khan, Mirwaise

doi:10.19045/bspab.2019.80079

Cited by 3 publications

(4 citation statements)

References 4 publications

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“…Such a relationship, expressed in decrease in the mortality of rats exposed to lethal doses of γ-radiation on the background of preliminary intake of CdCl2, suggests the presence of radioprotective properties of MT. This assumption is supported by available literature data on the radically induced formation of MT [10,11].…”

Section: Group Of Animalssupporting

confidence: 72%

The effect of immunotherapy on the state of the antioxidant system in radiation damage in rats

Gainullin,

Plotnikova,

Shakurov

et al. 2023

E3S Web Conf.

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Immunotropic drugs (such as sera, blood plasma and immunoglobulins) have polyfunctional activity with anti-infectious, antitoxic, homeostasis-regulating properties. Based on this, we conducted the present study with the purpose to evaluate the therapeutic effect of anti-cadmium -anti-radiation serum (AARS) on the level of radiation-chemical damage. Modeling of experimental radiation-chemical damage was carried out by preliminary 4-time subcutaneous injection of cadmium chloride solution (CdCl2) at doses of 1/500 LD50, followed by radiation exposure of 90 outbred white rats at doses of 7.0 and 9.0 Gy (LD50 and LD100, respectively). It was found that a single subcutaneous injection of TDC at a dose of 25 mg/kg of live weight 24 hours after the combined radiation-toxic damage had a radioprotective and antitoxic effect, increasing the survival rate of animals affected by lethal doses of CdCl2 and γ-rays. Increase in the survival rate of animals treated with the test agent after exposure to two-factor damage was due to inhibition of the concentration of BFR-active toxic compounds and reciprocal increase in the synthesis of metallothioneins and SOD. Thus, the use of immunotropic agent of anti-cadmium anti-radiation serum (AARS) after exposure to two-factor combined radiation-chemical damage provided 90% survival rate by induction of increased formation of metallothioneins and SOD, inhibition of redox-cycled toxic radicals formation and neutralization of cadmium toxicity with the help of anti-cadmium antibodies.

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Section: Group Of Animalssupporting

confidence: 72%

The effect of immunotherapy on the state of the antioxidant system in radiation damage in rats

Gainullin,

Plotnikova,

Shakurov

et al. 2023

E3S Web Conf.

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“…In scientific articles [5][6][7][8][9] presents the results of studying the efficiency of production and use of biohumus. It has been established that biohumus contains organic and mineral substances available for plant nutrition.…”

Section: Discussionmentioning

confidence: 99%

“…Currently, an effective way to improve the efficiency of crop industries -fertilizer application. At the same time, the most relevant is the use of biological products and biofertilizers, among which stands out vermifertilizers [5,6,7].…”

Section: Introductionmentioning

confidence: 99%

The effect of vermicompost on the agrochemical properties of soils and the quality of pepper in the conditions of Yakutia

Grigorev,

Stepanova,

Grigoreva

et al. 2024

E3S Web Conf.

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The purpose of this paper is to the results of experiments to study the effect of vermifertilizers on the agrochemical properties of soils and the quality of pepper in Yakutia. Experiments on testing vermifertilizers were carried out on peppers of the “Nezhnost” variety. Experiment scheme: 1 variant - was only with soil; variant 2 in addition to this vermicompost - 100 g; variant 3 vermicompost - 300 g; variant 4 vermicompost - 500 g; variant 5 - the biological product “Baikal EM 1” - 100 ml per well with 100 g semirotted manure. Vitamin C and nitrate content was studied in fruits. During the experiments, it was found that the optimal doses of vermicomposts made it possible to increase the content in soil mixture of nitrogen by 0.11%, P by 16.37%, K by 8.02% and organic matter by 0.34%. At the same time, vitamin C increased in the fruits of pepper and the content of nitrates decreased. The best result was obtained by the variant where 500 g of vermicompost was used, the second-best result was for the biological products “Baikal EM-1”.

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“…Diazepam was administered intramuscularly at 5 mg/kg body weight. After 15 minutes, Ketamine was injected at 35 mg/kg body weight intramuscularly This anaesthetic protocol was adopted from published paper reported by Khan et al (2019).…”

Section: Group Dkmentioning

confidence: 99%

Comparative Clinical and Serum Biochemical Evaluation of Two Intramuscular Anaesthetic Combinations (Diazepam/Ketamine and Diazepam/Fentanyl/Ketamine) in Rabbits

Akter

Yesmin

TALUKDER

et al. 2022

Manas Journal of Agriculture Veterinary and Life Sciences

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The clinical efficacy and safety of preanaesthetics and induction agents were examined and compared on the basis of clinical and serum biochemical indicators in rabbits. Eight apparently healthy rabbits (3.0-3.5kg) of either sex were arbitrarily allocated into two groups: Group DK (diazepam-ketamine) and Group DFK (diazepam-fentanyl- ketamine). Rabbits were received intramuscular diazepam (5mg/kg), fentanyl (0.02 mg/kg) and ketamine (35 mg/kg). Data on clinical parameters (rectal temperature, heart rate and respiratory rate) and reflexes (righting reflex, palpebral reflex and pedal reflex) were evaluated before and at 10, 20, 30, 40, 50, 60, 70, 80, 90 and 100 minutes after injection of anaesthetics. Blood samples were aspirated prior to anaesthesia and 30 minutes following induction. Serum Albumin, Globulin, Cholesterol, Triglyceride, Total Protein, High Density Lipoprotein (HDL), Low Density Lipoprotein (LDL), Creatinine, Calcium, Phosphorus, Sodium, Potassium and Chlorine were evaluated through semiautomatic biochemistry analyzer. In this study, no significant changes in rectal temperature were observed in the animals of group DK during anaesthesia. During anaesthetic cascade, heart rates and respiration rates in both the groups were reduced significantly (P< 0.05). In DFK-injected rabbits, the return of righting and palpebral reflexes were delayed. The DFK groups had considerably (P< 0.05) longer surgical anaesthesia than the DK groups. In terms of serum biochemistry, DK-treated rabbits had significantly lower total protein, globulin, creatinine, HDL, sodium, and potassium concentrations (P< 0.05). Total protein, cholesterol, HDL, and potassium levels decreased significantly (P

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Comparative study of isoflurane and ketamine anesthetics in Rabbits

Cited by 3 publications

References 4 publications

The effect of immunotherapy on the state of the antioxidant system in radiation damage in rats

The effect of immunotherapy on the state of the antioxidant system in radiation damage in rats

The effect of vermicompost on the agrochemical properties of soils and the quality of pepper in the conditions of Yakutia

Comparative Clinical and Serum Biochemical Evaluation of Two Intramuscular Anaesthetic Combinations (Diazepam/Ketamine and Diazepam/Fentanyl/Ketamine) in Rabbits

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