Comparative Study of Monoclonal Antibody Scan in Diagnosing Orthopaedic Infection

Hakki, Sam; Harwood, Steven J.; Morrissey, Michele A.; Camblin, J; Laven, David L.; Webster, William

doi:10.1097/00003086-199702000-00029

Cited by 60 publications

(14 citation statements)

References 12 publications

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“…Imaging with technetium‐labelled anti‐leukocyte antibodies has high sensitivity and specificity for the detection of orthopaedic infections, and is low in cost, non‐invasive and rapid [6,13]. LeukoScan is used for imaging inflammation in vivo .…”

Section: Characteristics Of 25 Patients With Brucellosis But Not Sponmentioning

confidence: 99%

Use of sulesomab in the diagnosis of brucellar spondylitis

Iaria

Campennì²,

Blandino

et al. 2004

Clinical Microbiology and Infection

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Twenty-two patients with suspected brucellar spondylitis were investigated to evaluate the possible diagnostic role of Sulesomab, a (99m)Tc-antigranulocyte antibody Fab' fragment. Sensitivity and specificity were compared with those of magnetic resonance imaging (MRI). Skeletal involvement was detected by MRI in 11 cases, while leukoscintigraphy indicated normal vertebral uptake in seven of these patients, increased uptake in two patients, and decreased uptake in two patients. Leukoscintigraphy of the 11 patients negative by MRI demonstrated increased uptake in two cases. The sensitivity and specificity of leukoscintigraphy were 27.2% and 81.1%, respectively. Based on these results, leukoscintigraphy is not indicated for the management of patients with suspected brucellar spondylitis.

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Section: Characteristics Of 25 Patients With Brucellosis But Not Sponmentioning

confidence: 99%

Use of sulesomab in the diagnosis of brucellar spondylitis

Iaria

Campennì²,

Blandino

et al. 2004

Clinical Microbiology and Infection

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“…This may be partly the result of small or single-patient samples, or patients with bone and soft-tissue infections, endoprostheses, metal implants, or spine and pelvis changes were included in the studies. 3,5,9,19,[21][22][23][24][25] In the current retrospective study, a high sensitivity of 95% was obtained for 20 of 30 true-positive findings, in 6 of 30 true-negative findings, a relatively high specificity of 67%, and a high diagnostic 19 who reported a sensitivity of 88% and 100%, a specificity of 75%, and a diagnostic accuracy of 80%. The current study showed a false-positive result in 3 of the 30 patients.…”

Section: Discussionmentioning

confidence: 43%

Imaging Osteomyelitis With Tc-99m-Labeled Antigranulocyte Antibody Fab′ Fragments

Rothenburg

Schaffstein²,

Ludwig³

et al. 2003

Clinical Nuclear Medicine

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PURPOSE The purpose of this study was to evaluate the diagnostic value of Tc-99m-labeled antigranulocyte antibody fragments in the diagnosis of osteomyelitis. MATERIALS AND METHODS Thirty immunoscintigrams were evaluated retrospectively with 740 MBq (20 mCi) Tc-99m-labeled antigranulocyte antibodies. The final diagnoses were confirmed by histology, magnetic resonance imaging, computed tomography, and clinical follow-up. RESULTS In the retrospective analysis, 20 of 30 patients (67%) demonstrated a true-positive result. Three of 30 patients (10%) had a false-positive result. A false-negative result was found in a diabetic patient with a perforating ulcer of the foot. Six of 30 patients had a true-negative result. A high sensitivity of 95%, a relatively high specificity of 67%, and a high diagnostic accuracy of 86% were present in this study. CONCLUSION Tc-99m labeled monoclonal antibody-Fab' fragments are suitable for the detection of osteomyelitis. Its clinical application is simple. Its use guarantees a reliable and accurate diagnostic result just 1 to 2 hours after injection, making a late scan unnecessary. Coxarthrosis or hyperostosis can lead to false-positive results. A perforating ulcer of the foot may result in a false-negative conclusion.

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“…Several new agents for imaging inflammation that have been reported recently are not associated with the problem of simultaneous uptake in bone marrow, such as radiolabeled anti-E-selectin, 20,21 Tc-99m-labeled ciprofloxacin, 22 Tc-99m sulesomab 23,24 and other antigranulocyte antibodies, 25 polyclonal human immunoglobulin, 26 and Tc-99m-labeled interleukin-8. 27 Nevertheless, leukocyte scintigraphy remains the gold standard, and so attempts to consolidate its diagnostic accuracy are worthwhile.…”

Section: Discussionmentioning

confidence: 99%