Use of sulesomab in the diagnosis of brucellar spondylitis

Abstract

Twenty-two patients with suspected brucellar spondylitis were investigated to evaluate the possible diagnostic role of Sulesomab, a (99m)Tc-antigranulocyte antibody Fab' fragment. Sensitivity and specificity were compared with those of magnetic resonance imaging (MRI). Skeletal involvement was detected by MRI in 11 cases, while leukoscintigraphy indicated normal vertebral uptake in seven of these patients, increased uptake in two patients, and decreased uptake in two patients. Leukoscintigraphy of the 11 patients negative by MRI demonstrated increased uptake in two cases. The sensitivity and specificity of leukoscintigraphy were 27.2% and 81.1%, respectively. Based on these results, leukoscintigraphy is not indicated for the management of patients with suspected brucellar spondylitis.

Gliomas with intratumoral abscess formation: Description of new cases, review of the literature, and the role of 99mTC‐Leukoscan

“…In addition Gratz et al [7,8] reported an overall sensitivity and specificity of 76% and 84%, respectively, of Leukoscan scintigraphy for the diagnosis of infections involving bone, arthroplastic joint, or other tissues in 138 patients. Similar results were achieved by Cascio et al [30] in patients affected by brucellar spondylitis; the low sensitivity (27.2%) of Leukoscan in these patients was correlated with the chronic phase of the disease.…”

The Comparison of the Manifestation of the Clinical Imageology and Pathology between the Brucellar Spondylitis and the Spine Turberculosis

“…Thoracolumbar spinal tuberculosis involving the vertebral body and more for osteolytic destruction, destruction of lesion or most often involving a vertebral destruction sequestrum see multiple irregularities in the kitchen, often involving the destruction of the vertebral pedicle rear, adjacent vertebral density generally reduced, local tissue reactions were; intervertebral disc damage, uneven density, there are "stars" like dead bone residue scattered in which the adjacent vertebral endplates irregular bone destruction or disappearance, most accompanied by paraspinal abscess formation, and calcification within the common abscess, abscess often exceed the length of the vertebral lesion formation flow injection abscess, abscess edge signal enhancement [24,25]; tuberculosis of the spine is the most reliable MRI features "jump lesion" and thin and smooth abscess wall and enhanced well-defined paraspinal abnormal signal (Figure 17) [26,27]. The Brucella spondylitis and more involved in the lower lumbar vertebral segments and 1 -2 [2,17], which is characterized by thick, irregular enhanced MRI abscess wall and ill-defined paraspinal abnormal signal, T1WI showed low signal, T2WI high signal to bone destruction evident when, T2WI high signal on fat suppression such as vertebrae, discs, accessories and intraspinal showed heterogeneous high signal (Figure 18) [2,3,[28][29][30][31].…”