Comparative Study of One-Step Cross-Linked Electrospun Chitosan-Based Membranes

Abstract

Chitosan membranes are widely applied for tissue engineering; however, a major drawback is their low resistance in aqueous phases and therefore the structure collapses impeding their long-term use. Although there is extensive research, because of chitosan’s importance as a biomaterial, studies involving chitosan-based membranes are still needed. Herein, a detailed investigation of diverse chemical routes to cross-link fibers in situ by electrospinning process is described. In case of using genipin as cross-linker, a close relationship with the content and the mean diameter values is reported, suggesting a crucial effect over the design of nanostructures. Also, the physical resistance is enhanced for the combination of two types of methods, such as chemical and physical methods. Cross-linked fibers upon exposure to long wave ultraviolet A (UVA light) change their morphology, but not their chemical composition. When they are incubated in aqueous phase for 70 days, they show an extensive improvement of their macrostructural integrity which makes them attractive candidates for tissue engineering application. As a result, the thermal properties of these materials reveal less crystallinity and higher temperature of degradation.

Development of Flexible Plasticized Ion Conducting Polymer Blend Electrolytes Based on Polyvinyl Alcohol (PVA): Chitosan (CS) with High Ion Transport Parameters Close to Gel Based Electrolytes

“…The properties of crystalline semiconductors and insulators have been determined by several solid state theories, but when these theories are applied to data on polymers, the predictions they produce are not sufficiently unique, making it surprisingly difficult to determine all the important characteristics of electrical conduction in polymers even today [99]. The σ ac were evaluated from the real (Z r ) and imaginary (Z i ) parts of complex impedance (Z*) using Equation (14) .…”

“…Chitosan (CS), a biopolymer derived from chitin and used in a variety of medicinal and electrochemical devices, is safe, nontoxic, and biodegradable [ 13 ]. The backbone structure of CS differs from other biopolymers because it contains amino and hydroxyl functional groups [ 14 ]. Poly (vinyl alcohol) (PVA), on the other hand, is a water-soluble polymeric substance with high dielectric strength, strong charge storage capacity, and fascinating optical features [ 15 ].…”

Inflammation-Responsive Drug-Conjugated Dextran Nanoparticles Enhance Anti-Inflammatory Drug Efficacy

“…26 To enhance controlled release, stimuli-responsive linkers have recently been incorporated into the polymer-drug conjugates. [27][28][29][30][31][32] However, few responsive linkers in general have been reported, especially for ROS-responsive conjugates. [33][34][35] Phenylboronic acids (PBA)-the well-known Suzuki coupling reagent-react with ROS, resulting in the cleavage of covalent bond between the carbon and boron.…”

Çapraz Bağlı Kitosan Selüloz Grafen Kompozitinin Şişme Davranışlarının İncelenmesi

“…Kompozit bileşenlerinin oranları daha önce yapılan çalışmalar referans alınarak belirlenmiştir [1]. GA miktarı ise ilgili literatüre dayanılarak GA'nın bağlanacağı NH2 grubu oranına göre belirlenmiştir [13].…”

“…G'nin üstün özellikleri, selülozun iyi mekanik ve kimyasal yapı özellikleri ve kitosanın antibakteriyel, biyouyumluluk özellikleri ve fonksiyonel grupları yardımıyla çapraz bağlı geliştirilmiş özellikleri ile üçlü biyo-nano kompozit sistemi üretilebilir. Selüloz, kitosan ve grafen kullanılarak üretilmiş kompozit malzemeler ilaç taşıma sistemleri [10], paketleme [11], kaplama [12], membranlar [13], implantlar [14], doku mühendisliği [15], yara örtüsü [16], su arıtma [17] ve akıllı tekstiller [18] gibi birçok uygulama alanı bulabilmektedir.…”