Comparative Study of Pagetoid Dyskeratosis Between Acrochordons and Soft Fibromas

Piqué-Duran, Enric; Palacios-Llopis, Santiago; Moreno-Ramis, Pedro; Pérez-Cejudo, Juan A.; Martínez-Martín, M

doi:10.1097/01.dad.0000208265.05109.a0

Cited by 17 publications

(5 citation statements)

References 15 publications

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“…In the setting of normal and pathologic nipple PD may appear, for the nipples are susceptible to trauma as a result of their protrusion, and to friction from contact with surrounding structures. Recently PiquéÂ©‐Duran et al (25) observed that PD was more frequently seen in soft fibromas than in acrochordons. The former lesions are larger and more susceptible to friction or trauma.…”

Section: Discussionmentioning

confidence: 99%

Pagetoid dyskeratosis of the nipple epidermis: an incidental finding mimicking Paget's disease of the nipple

Garijo

Val

Val-Bernal³

2008

APMIS

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Pagetoid dyskeratosis (PD) is considered a selective keratinocytic response in which a small part of the normal population of pale keratinocytes is induced to proliferate. PD has been found incidentally in the squamous epithelium of the skin and mucosas in various locations, but not in the nipple. In cases in which PD cells are conspicuous, there is the danger of overdiagnosis. In a retrospective study, we describe the location and incidence of PD and other pale cells in the nipple epidermis, in 288 mastectomy specimens from women operated on for breast carcinoma, in situ or infiltrating, selected consecutively from our histopathologic files. In addition to the conventional histologic methods an immunohistochemical study was performed in selected cases. PD was found in 184 (63.9%) cases and was a prominent finding in 37 (12.8%) cases. Toker cells (TCs) were identified by standard light microscopy in 24 (8.3%) nipples. Paget carcinoma cells (PCCs) were found in 12 (4.2%) cases, and in 9 (3.1%) they were an incidental finding. The immunohistochemical profile of each type of pale cells was as follows: PD cells, EMA-,LMWCK-,CK7-,HMWCKπ, CEAª, HER2/neu proteinª, HMB45ª, HPVª; TCs, EMAπ, LMWCKπ, CK7π, HMWCKª, CEAª, HER2/neu proteinª, HMB45ª, HPVª; PCCs, EMAπ, LMWCKπ, CK7π, HMWCKª, CEAπ, HER2/neu proteinπ, HMB45ª, HPVª. In conclusion, friction may be the stimulus for the appearance of PD cells. PD cells must be distinguished from TCs, PCCs, clear cells of Bowen's disease, pagetoid melanoma cells, cells of clear cell papulosis, koilocytes, artifactual clear cells, and glycogen-rich squamous cells. A combination of immunohistochemical markers is useful for this distinction; however, routine histologic study is usually adequate for recognizing PD. Pathologists should be familiar with the histologic features of PD in the nipple epidermis to avoid misdiagnosis. The epidermal surface of the nipple and areola has a somewhat wrinkled appearance and is darker than that of the surrounding skin. The normal stratified squamous epithelium of the nipple-areolar complex may contain pale or

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Section: Discussionmentioning

confidence: 99%

Pagetoid dyskeratosis of the nipple epidermis: an incidental finding mimicking Paget's disease of the nipple

Garijo

Val

Val-Bernal³

2008

APMIS

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“…This feature is often seen in histopathologic specimens obtained from the intertriginous areas, the perianal zone, vulva, and penis and is considered to represent a reactive process in which a small part of the normal population of keratinocytes is induced to proliferate, possibly by friction. [42][43][44] Rubbing of the lesions because of their large size is a likely explanation in our case. J AM ACAD DERMATOL VOLUME 67, NUMBER 6 It is known that patients with TSC2 alterations manifest a more severe phenotype than patients with TSC1.…”

Section: Discussionmentioning

confidence: 80%

Giant angiofibromas in tuberous sclerosis complex: A possible role for localized lymphedema in their pathogenesis

Kacerovská

Kerl

Michal

et al. 2012

Journal of the American Academy of Dermatology

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“…Tschen et al hypothesized that the cells represent a small population of the normal keratinocytes that are induced to proliferate by an external trigger, such as mechanical trauma or friction [ 1 ]. Piqué-Duran et al found that lesions of the axilla more frequently demonstrated pagetoid dyskeratosis in comparison to those of other locations; they suggested that this observation supports the theory that moisture and friction contribute to the development of pagetoid dyskeratosis [ 14 ].…”

Section: Discussionmentioning

confidence: 89%

“…The pathologic differential diagnosis of pagetoid dyskeratosis includes other conditions with clear cells in the epidermis (Table 2 ) [ 3 , 14 - 16 ]. In some circumstances, immunoperoxidase staining or other stains (in addition to hematoxylin and eosin) may help differentiate these conditions.…”

Section: Discussionmentioning

confidence: 99%

Pagetoid Dyskeratosis of the Male Genitalia: Case Report and Review

Werbel

Cohen²

2018

Cureus

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Pagetoid dyskeratosis is a benign incidental pathologic finding that has been reported in many distinct skin lesions on various locations of the body. A man who had pagetoid dyskeratosis within lesions of the penile shaft is described and similar cases of pagetoid dyskeratosis in lesions of the male genitalia are reviewed. The patient was a 26-year-old healthy man who developed several asymptomatic penile papules that were refractory to topical imiquimod 5% cream and cryotherapy. Snip biopsies were performed and microscopic examination revealed pagetoid dyskeratosis. PubMed was searched for the following terms: cell, clear, dyskeratosis, genitalia, pagetoid, penile, penis, prepuce, scrotum, and shaft. The papers containing these terms and their references were reviewed. Pagetoid dyskeratosis has been observed in lesions on the prepuce and scrotum; this case report now expands the distribution of this finding to the penile shaft. Clinicians and pathologists should be aware of this intriguing potential incidental finding within skin lesions of the male genitalia.

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Comparative Study of Pagetoid Dyskeratosis Between Acrochordons and Soft Fibromas

Cited by 17 publications

References 15 publications

Pagetoid dyskeratosis of the nipple epidermis: an incidental finding mimicking Paget's disease of the nipple

Pagetoid dyskeratosis of the nipple epidermis: an incidental finding mimicking Paget's disease of the nipple

Giant angiofibromas in tuberous sclerosis complex: A possible role for localized lymphedema in their pathogenesis

Pagetoid Dyskeratosis of the Male Genitalia: Case Report and Review

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