Comparative Study of Platelet count and C-Reactive Protein among Gram Positive, Gram Negative and Fungal Sepsis in Newborns

Parakh, Hemant; Jk, Ramesh; Reddy, Prashant

doi:10.17511/ijmrr.2015.i2.026

Cited by 3 publications

(5 citation statements)

References 31 publications

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“…Similarly, while comparing hematological, infectious, and blood complete counts, it was discovered that in the case of C-reactive protein, the greater the CRP level, the lower the platelet level. This finding was also supported by Rabindran et al, in which they studied the CRP with platelet level in neonates and found out that the greater the CRP, the higher the thrombocytopenia [ 25 ]. Furthermore, the severity of gram-negative sepsis increased.…”

Section: Discussionsupporting

confidence: 65%

Frequency and Severity of Thrombocytopenia in Neonatal Sepsis

Arabdin¹,

Khan²,

Zia³

et al. 2022

Cureus

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BackgroundNeonatal sepsis includes numerous systemic illnesses such as septicemia, meningitis, urinary tract infections, and pneumonia. In developing countries, the major reason for neonatal mortality is septicemia, which accounts for almost 50% of overall deaths. Thrombocytopenia is one of the most common hematological problems during the neonatal period, affecting the majority of sufferers admitted to the neonatal intensive care unit (NICU). The aim of our study was to find the frequency of thrombocytopenia and its severity in neonates with sepsis.

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Section: Discussionsupporting

confidence: 65%

Frequency and Severity of Thrombocytopenia in Neonatal Sepsis

Arabdin¹,

Khan²,

Zia³

et al. 2022

Cureus

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“…Rabindran et al also found that risk of fungal sepsis was significantly higher in lower birth weight babies as compared to bacterial sepsis (p value = 0.014). 10 In the present study, majority of the maternal factors were found insignificant like meconium stained liquor (MSL), per vaginal examinations >3 and maternal fever and mode of delivery. Similar result for mode of delivery was found by Ho Lim W et al, Chib R et al 12,9 There were some studies on risk factors for fungal sepsis which showed insignificance of mode of delivery like Chaurasia D et al and Yunus M et al 24,11 On the other hand, Swanson JR et al found caesarean section as a significant risk factor for Candidial sepsis (p value <0.0001).…”

Section: Discussionmentioning

confidence: 46%

“…Corroborating with the present findings, Rabindran et al found higher incidence of reactive CRP (p value = 0.003) in fungal sepsis as compared to bacterial sepsis. 10 Study by Ho Lim W et al also showed similar result (100% versus 83.5%, p value = 0.009). 12 In systemic fungal infections, CRP levels are high as compared to superficial fungal infections like acute fungal stomatitis.…”

Section: Discussionmentioning

confidence: 57%

“…25 In the present study, thrombocytopenia (platelet count <1.0 lac) occurred significantly more in fungal sepsis as compared to bacterial ones, 91.53% versus 51.51% (p value ≤0.001). Warris et al gave similar results (100% versus 50%), so did, Rabindran et al, Charoo et al, and Ho Lim W et al 25,10,26,12 While Manzoni P et al found no significant difference (19.6% versus 16.4%). 27 This study revealed that C-reactive protein (CRP) was reactive in 84.75% cases of fungal sepsis while it was reactive in only 59.04% cases of bacterial sepsis.…”

Section: Discussionmentioning

confidence: 71%

“…9 Also, Rabindran et al notes 88.47% bacterial cases and 11.53% fungal cases. 10 15,16,12,[17][18][19] Higher incidence of late onset sepsis in our study can be because of outborn admissions, longer hospital stays and increased invasive procedures and device usage.…”

Section: Discussionmentioning

confidence: 99%

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Comparative study of clinic-microbiological profile of fungal and bacterial sepsis in neonates

Sharma

Karnawat

Gupta

2018

Int J Contemp Pediatr

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Background: Neonatal sepsis both bacterial and fungal sepsis is a major cause of neonatal mortality in India. This study is an attempt at determining the spectrum of fungal and bacterial infections in our NICU and ways to differentiate fungal from bacterial sepsis.Methods: All culture positive cases of bacterial and fungal sepsis from neonates in nursery of JLN hospital Ajmer from November 2016 to November 2017 were included in the study. The bacterial and fungal cases were compared for clinical and laboratory features, complications and outcome. Chi square test was used.Results: Culture positive sepsis was found in 391 cases out of total 2190 cases (17.8%) out of which 84.9% were bacterial (EONS 30% and LONS 70%) and 15.1% fungal (EONS 33.8% and LONS 66.1%). Fungal sepsis was found more in lower gestational age (55.9% versus 31.3%; p value 0.003) and in lower birth weight babies (76.2% versus 62.9%; p-value 0.004). Mortality rate was higher in fungal group (40% versus 19.5%; p-value: 0.0003). WBC count of <5000, platelet count <1.5 lac, reactive CRP, hyperglycemia, NEC, ventilation was significantly higher in fungal sepsis. While meconium stained liquor, per vaginal exams >3, maternal fever, mode of delivery, hypoglycemia, increased serum creatinine, respiratory distress, deranged CRT, temperature instability, intra cranial haemorrhage and length of hospital stay were found to be insignificant.Conclusions: In this study fungal sepsis when compared with bacterial sepsis, was found to be associated more with complications and mortality.

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Clinical Characteristics, and Outcomes of Severe Neonatal Thrombocytopenia: a Retrospective Cohort Study in China

Shan,

Peng,

Zhang

et al. 2024

Preprint

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Background: Severe neonatal thrombocytopenia, as a rare but life-threatening disease with multiple etiologies, has limited relevant reports in China. The single-center study was performed in a severe thrombocytopenic cohort to improve the prognosis of this disease. Methods: We included all the patients diagnosed with severe thrombocytopenia (platelet counts £ 50×103/μL) in our institution between October 2016 and February 2021, and retrospectively reviewed their electronic records. Comparisons were made according to etiology and outcome. Results: Among the 5819 inpatients, 194 with severe thrombocytopenia were included in this study, with 64.4% of the cases occurring within 72 hours of life. The highest incidence was recorded among extremely low birth weight neonates (6.5%). The main etiologies included sepsis (22.2%), genetic syndromes (14.4%), perinatal asphyxia (9.8%), necrotizing enterocolitis (NEC; 8.8%), and cytomegalovirus infection (6.7%). The mean (SD) platelet nadir was 26.0 (14.0) × 103/μL, and 112 patients developed very severe thrombocytopenia (platelet counts £ 30×103/μL), of which 21.4% were caused by late-onset sepsis. In 45 culture-positive cases, the gram-negative group had a lower level of platelets (mean [SD]: 28 [11]×103/μL) as compared to the gram-positive group (mean [SD]: 39 [12]×103/μL). A total of 120 cases (61.9%) exhibited evidence of hemorrhage, with patients diagnosed with NEC demonstrating the highest incidence of hemorrhage at 58.8%. The platelet counts took a median of 10 days to recover: 11 and 7 days for early and late-onset cases; 15 days without and 21 days with platelet transfusions, respectively. The overall mortality rate was 26.8%. The causes of severe thrombocytopenia in 32.7%, 19.2%, and 17.3% of patients who died were identified as sepsis, birth asphyxia, and NEC, respectively. The levels of PT (P = 0.025), APTT (P = 0.046), and lactate (P = 0.028) were lower among surviving patients. Conclusions: Sepsis, genetic syndromes, and perinatal asphyxia are the predominant etiologies of severe neonatal thrombocytopenia in China. The overall prognosis of severe neonatal thrombocytopenia is poor, but its severity and short-term prognosis can be determined by relevant laboratory tests and the etiology.

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Comparative Study of Platelet count and C-Reactive Protein among Gram Positive, Gram Negative and Fungal Sepsis in Newborns

Cited by 3 publications

References 31 publications

Frequency and Severity of Thrombocytopenia in Neonatal Sepsis

Frequency and Severity of Thrombocytopenia in Neonatal Sepsis

Comparative study of clinic-microbiological profile of fungal and bacterial sepsis in neonates

Clinical Characteristics, and Outcomes of Severe Neonatal Thrombocytopenia: a Retrospective Cohort Study in China

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