Comparative study of retinal injuries induced by a 420-750 nm supercontinuum source and a 532 nm laser

Jiao, Lei; Fan, Yan; Wang, Jiarui; Yang, Zaifu

doi:10.1364/boe.10.003018

Cited by 4 publications

(3 citation statements)

References 35 publications

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“…By weighting the data of spectrum by an action spectrum and summing up the wavelength range, the effective exposure level could be obtained and compared with the minimum laser exposure limit. In previous reports, we normalized the damage data through appropriate thermal hazard action spectra 19,20 . Using the ELs from ICNIRP or the MPEs from IEC 60825‐1 and ANSI Z136.1, 15–17 the corneal injury action spectra could be obtained.…”

Section: Methodsmentioning

confidence: 99%

“…In previous reports, we normalized the damage data through appropriate thermal hazard action spectra. 19,20 Using the ELs from ICNIRP or the MPEs from IEC 60825-1 and ANSI Z136.1, [15][16][17] the corneal injury action spectra could be obtained. Then the effective damage threshold could be calculated.…”

Section: Experimental Procedures and Data Analysesmentioning

confidence: 99%

“…In 2014, we first investigated the ocular damage effects induced by a Vis-IR SC source which covered the spectrum from 450 to 2500 nm, and found that the retina was the most vulnerable part compared with other ocular media. 18 In 2019, we further conducted a comparative study of retinal injuries induced by a 420-750 nm SC source and a 532 nm laser in the chinchilla gray rabbit model and determined the retinal damage thresholds for the exposure durations of 0.1, 1.0, and 10.0 s. 19 No significant difference could be found for the damage effects between the SC source and the laser source at the wavelength of 532 nm, and analysis of the damage thresholds confirmed that the effects were additive for retinal exposures to multiple wavelengths or broadband light source. We also noted that corneal damages by SC are also possible because SC usually has the spectral components of infrared radiation above 1400 nm, which are significantly absorbed by the cornea.…”

Section: Introductionmentioning

confidence: 99%

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Corneal damage threshold induced by supercontinuum source: A further study

Jiao,

Wang,

Wang

et al. 2023

Lasers Surg Med

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ObjectivesPrevious report shows that corneal spot size is an important influence factor on damage threshold induced by supercontinumm (SC) source. However, damage thresholds were determined for the spot size of only 0.37 mm due to the low output of the employed SC source at that time. The objectives of this study are to determine the lowest possible corneal damage threshold at a large corneal spot size using a more powerful SC source and provide data for the future possible refinements of laser safety standards.Materials and MethodsA series of experiments was conducted in the New Zealand white rabbit model to determine the corneal damage threshold induced by a 900–2000 nm SC source, with corneal 1/e beam diameter of about 1.2 mm. Slit‐lamp biomicroscope was employed to reveal the corneal damage characteristics. By employing the action spectra determined through the analysis of current laser safety guidelines and standards, the effective damage threshold could be calculated.ResultsThe determined damage threshold given in terms of the peak radiant exposure for the exposure duration of 0.14 s was 44.3 J/cm2. At threshold level, corneal damages involved the epithelium and the shallower stroma. The safety factor between the effective damage threshold and the corresponding maximum permissible exposure (MPE) was about 45.ConclusionsPresent corneal MPEs in the wavelength range of 700–1200 nm may be conservative and corneal damage thresholds for the infrared A wavelengths should be determined in future studies.

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Section: Methodsmentioning

confidence: 99%

Section: Experimental Procedures and Data Analysesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Corneal damage threshold induced by supercontinuum source: A further study

Jiao,

Wang,

Wang

et al. 2023

Lasers Surg Med

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Corneal Damage Effects Induced by a 770–2,500 nm Supercontinuum Light Source

et al. 2019

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Background and ObjectivesWidespread applications of supercontinuum (SC) source lead to the possibility of ocular damages. However, the corneal damage effects induced by SC have not been explored before. The objectives of this study are to determine the rabbit corneal injury threshold for SC radiation and to examine whether the existing safety guidelines and standards are suitable for the hazard evaluation of this new kind of light source.Study Design/Materials and MethodsA series of experiments was conducted in the New Zealand white rabbit model to determine the corneal damage thresholds induced by a 770–2,500 nm SC source, with a corneal 1/e beam diameter of 0.37 mm. Through slit‐lamp biomicroscope, optical coherence tomography (OCT), and histopathology the corneal damage characteristics at the threshold level were revealed. By employing the action spectra determined through the analysis of safety guidelines and standards, the damage thresholds for SC source could be compared with the corresponding exposure limits.ResultsThe determined damage thresholds given in terms of the peak radiant exposure for exposure durations of 2.0 and 10.0 seconds were 2.1 × 103 and 7.4 × 103 J/cm2, respectively. At threshold level, corneal damages involved the epithelium and the shallower stroma, and no obvious changes could be found in the deep stroma, Descemet's membrane, and endothelium.ConclusionsThe exposure limits for the anterior parts of the eye in the wavelength range of 700–1,200 nm are overly conservative. The obtained results contribute to the knowledge base for the hazard evaluation of SC source. Lasers Surg. Med. © 2019 Wiley Periodicals, Inc.

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