Comparative study of rosmarinic acid content in some plants of Labiatae family

Shekarchi, Mohammad; Hajimehdipoor, Homa; Saeidnia, Soodabeh; Gohari, Ahmad Reza; Hamedani, M Pirali

doi:10.4103/0973-1296.93316

Cited by 194 publications

(86 citation statements)

References 23 publications

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“…Reference solutions of rosmarinic acid (major constituent in the plant (Shekarchi, Hajimehdipoor, Saeidnia, Gohari, & Hamedani, 2012)) were prepared by dissolving accurately weight of rosmarinic acid in methanol (10, 30, 60, 100, and 120 ng/µl). The correlations of peak area of standard rosmarinic acid versus concentrations (as ng/ µl) were plotted and the calibration curve showed linearity over the studied concentration range with regression coefficient (r 2 ) 0.995.…”

Section: Sample and Reference Standard Preparationmentioning

confidence: 99%

Mentha longifolia alleviates experimentally induced angina via decreasing cardiac load

2018

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Angina occurs due to imbalance between heart oxygen demand and supply and is associated with serious morbidity and mortality. Here, the possible antianginal effect of Mentha longifolia extract was studied in experimental model of angina. Aerial parts of M. longifolia were extracted, standardized, and given to rats three days before angina. Heart hemodynamics and conductivity were recorded by microtip catheter and surface electrodes. M. longifolia extract significantly alleviated the sustained decline in cardiac contractility after vasopressin exposure. However, M. longifolia did not affect the impaired cardiac dilation after vasopressin. Heart rate was significantly decreased after vasopressin exposure in rats treated with M. longifolia compared with untreated animals. In addition, M. longifolia produced more increase in systolic and diastolic durations after vasopressin exposure compared with untreated animals. Moreover, the plant extract alleviated the ST height changes during vasopressin injection. M. longifolia extract alleviates impaired cardiac function associated with angina through decreasing heart work. Practical applications The present study is the first to study the effect of M. longifolia in an experimental model of angina. M. longifolia alleviated the impaired cardiac contractility associated with angina exposure. The antianginal effect of M. longifolia could be through reducing cardiac load. This can be concluded from the decrease in heart rate and the systolic and diastolic cycles elongation after exposure to vasopressin in animals pretreated with M. longifolia. This helps in reducing the associated cardiac ischemia upon exposure to vasopressin as indicated by ST change. This could provide new directions in the management of the serious angina disease.

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Section: Sample and Reference Standard Preparationmentioning

confidence: 99%

Mentha longifolia alleviates experimentally induced angina via decreasing cardiac load

2018

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“…RA is found in some of Labiateae family plants like Salvia, Melissa, Origanum, Lavandula, Rosmarinus, Thymus, Zataria, Mentha, Perovskia, Zhumeria, and Satureja species (13). It is also found in species of the Boraginaceae and in some fern and hornwort species (14).…”

Section: Discussionmentioning

confidence: 99%

A new validated high-performance liquid chromatography method for standardization of rosmarinic acid in Salvia extracts

Ghanadian¹,

Shamaeezadeh²,

Mohammadi³

et al. 2017

J Herbmed Pharmacol

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In the present study, a new validated HPLC method was developed which is suitable for analysis of rosmarinic acid and standardization of Labiateae family plants like Salvia, Melissa, Origanum, Lavandula, Rosmarinus, Thymus, Zataria, Mentha, Perovskia, Zhumeria, and Satureja species. Please cite this paper as: Ghanadian M Introduction:Tea bags or infuses of Salvia species from Lamiaceae family are traditionally used for the treatment of cough, and throat inflammations. They are known for antioxidant properties mainly related to the presence of rosmarinic acid (RA). Therefore it is necessary to develop a reliable analytical method for RA assay for standardization of Salvia species and also other plants containing RA like Melissa, Origanum, Lavandula, Rosmarinus, Thymus, Zataria, Mentha, Perovskia, Zhumeria, and Satureja species. In this study using a suitable extraction method by removing unwanted components present in crude methanol extract, phenolic content containing RA was extracted from dry powders of six Salvia species. Then, a suitable high-performance liquid chromatographic (HPLC) method was optimized for quantification of RA in Salvia species. Methods: HPLC analysis was done on a Waters system, equipped with 515 HPLC pump and waters 2487 dual wavelength absorbance detector. The column was a Nova-Pak C18 (3.9 × 150 mm), and Millenium software was used for the determination of the compounds and processing the data. The method was validated according to USP 32 requirements. Results: Among the investigated 6 species, S. virgata was the richest in RA level, demonstrating 3.50 ± 0.12 mg/g, followed by S. sclarea and S. chloroleuca showing 1.65 ± 0.08 and 1.65 ± 0.21 mg/g. S. ceratophylla with 0.10 ± 0.01 mg/g of RA in dried plant powder was the poorest. Conclusion:The validated HPLC method allows determination of amounts as low as 2.5 µg/ mL of RA and linearity in the ranges of 2.5-25 µg/mL and 100-600 µg/mL, which is suitable for standardization of Salvia species in traditional and pharmaceutical formulations.

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“…Rosmarinic acid (RA) is a polyphenol antioxidant carboxylic acid existed in many Lamiaceae herbs used commonly as culinary herbs, such as lemon balm ( Melissa officinalis ), rosemary ( Rosmarinus officinalis ), oregano ( Origanum vulgare ), sage ( Salvia officinalis ), thyme and peppermint [167,168]. RA possesses many biological activities including antioxidant, anti-inflammatory, anticancer, antiviral, antibacterial, and neuroprotective effects [169,170].…”

Section: Natural Productsmentioning

confidence: 99%

Natural Products as Promising Drug Candidates for the Treatment of Alzheimer’s Disease: Molecular Mechanism Aspect

Ansari¹,

Khodagholi

2013

107

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Alzheimer’s disease (AD) is the most common neurodegenerative disorder to date, with no curative or preventive therapy. Histopathological hallmarks of AD include deposition of β-amyloid plaques and formation of neurofibrillary tangles. Extent studies on pathology of the disease have made important discoveries regarding mechanism of disease and potential therapeutic targets. Many cellular changes including oxidative stress, disruption of Ca2+ homeostasis, inflammation, metabolic disturbances, and accumulation of unfolded/misfolded proteins can lead to programmed cell death in AD. Despite intensive research, only five approved drugs are available for the management of AD. Hence, there is a need to look at alternative therapies. Use of natural products and culinary herbs in medicine has gained popularity in recent years. Several natural substances with neuroprotective effects have been widely studied. Most of these compounds have remarkable antioxidant properties and act mainly by scavenging free radical species. Some of them increase cell survival and improve cognition by directly affecting amyloidogenesis and programmed cell death pathways. Further studies on these natural products and their mechanism of action, parallel with the use of novel pharmaceutical drug design and delivery techniques, enable us to offer an addition to conventional medicine. This review discussed some natural products with potential neuroprotective properties against Aβ with respect to their mechanism of action.

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Comparative study of rosmarinic acid content in some plants of Labiatae family

Cited by 194 publications

References 23 publications

Mentha longifolia alleviates experimentally induced angina via decreasing cardiac load

Mentha longifolia alleviates experimentally induced angina via decreasing cardiac load

A new validated high-performance liquid chromatography method for standardization of rosmarinic acid in Salvia extracts

Natural Products as Promising Drug Candidates for the Treatment of Alzheimer’s Disease: Molecular Mechanism Aspect

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