Comparative Study of Safety, Efficacy, and Tolerability of Aceclofenac Versus Diclofenac in Osteoarthritis Patients.

Kanaki, Anand R.; Patil, Rajesh S.; Santoshkumar, Jeevangi; Mala, Ravi D.

doi:10.14260/jemds/554

Cited by 3 publications

(2 citation statements)

References 35 publications

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“…Despite the continued reporting of cardiovascular risk associated with diclofenac [ 25 ], the prescription rate of aceclofenac has increased. Moreover, studies comparing the cardiovascular safety of aceclofenac and diclofenac are infrequent, although a trial involving 120 patients with osteoarthritis reported a better safety profile for aceclofenac [ 26 ]. A population-based case–control study conducted in Finland included aceclofenac as a study drug, although it was categorized under “other drugs” given the small number of exposures, for which its odds ratio was not calculated [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Trends in Ambulatory Analgesic Usage after Myocardial Infarction: A Nationwide Cross-Sectional Study of Real-World Data

2022

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Although current guidelines for myocardial infarction (MI) recommend caution in using non-steroidal anti-inflammatory drugs (NSAIDs), real-world studies of ambulatory settings are rare. This study aimed to explore the patterns and trends of analgesic prescriptions (especially NSAIDs) among patients with a history of MI in ambulatory care settings in Korea. We analyzed real-world data from the Korea National Health Insurance Service database. Patients aged 20 years or older hospitalized with incident MI were identified between January 2007 and December 2015. Ambulatory analgesics were administered after discharge from incident hospitalization for MI, and annual trends in the prescriptions of individual analgesics were evaluated. Among the 93,597 patients with incident MI, 75,131 (80.3%) received a total of 2,081,705 ambulatory analgesic prescriptions. Prescriptions were mainly issued at primary care clinics (80.3%). Analgesics were most frequently prescribed for musculoskeletal diseases (often NSAIDs, 70.7%); aceclofenac (13.7%) and diclofenac injection (9.4%) were the frequently used NSAIDs. Additionally, significant changes were observed in the trends for some analgesics, such as loxoprofen. This study suggested that NSAIDs are commonly prescribed to patients with a history of MI. Future real-world studies are needed to elucidate the drug–disease interactions of NSAIDs prescribed after MI, especially for patients with musculoskeletal diseases.

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Section: Discussionmentioning

confidence: 99%

Trends in Ambulatory Analgesic Usage after Myocardial Infarction: A Nationwide Cross-Sectional Study of Real-World Data

2022

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“…Известным и подтвержденным в клинических исследованиях является хондропротективный эффект ацеклофенака [29][30][31]. Путем ингибирования выработки металлопротеиназ ацеклофенак подавляет разрушительное действие воспаления на волокна коллагена, необходимые для поддержания нормальной структуры живой ткани [32].…”

Section: состояние пациентки было расценено как проявление вертеброге...unclassified

Cervicobrachial syndrome: diagnostic and treatment algorithms

Isaykin,

Akhmedzhanova,

Golenkova

et al. 2024

RJTAO

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Neck and shoulder disorders often occur side by side and reinforce each other in their clinical manifestations. Differential diagnosis of neck and shoulder pain can be challenging due to the close anatomical proximity, innervation of neck and shoulder structures, similarity of symptoms and groups of patients suffering from these conditions. Identifying the anatomical source of pain is the most important clinical task when choosing treatment for patients, which is reflected in two clinical observations. In the first clinical case the main complaint was pain in the shoulder; a neuro-orthopedic examination revealed evidence of radicular involvement in the form of a decrease in tendon reflex, pain provocation in Spurling and tension tests, with no evidence of involvement or pain in the joint structures of the shoulder. MRI of the cervical spine revealed signs of CVI discoradicular conflict consistent with the clinical symptoms. In the second observation, the main complaint was pain in the cervical spine and right shoulder, initially considered as radiculopathy; MRI revealed degenerative changes in the spine with possible compression of the CVI root. Neuro-orthopedic examination revealed no signs of radicular lesions; the main anatomical source of pain was coraco-acromial joint involvement, which was confirmed by diagnostic blockade of this joint. Both non-drug methods (kinesiotherapy, manual therapy, ergonomic measures) and medications (non-steroidal anti-inflammatory drugs — Airtal; muscle relaxants — Mydocalm) were used; therapeutic blockades targeting the main source of pain were performed. The cases presented show that it is impossible to determine the main anatomical source of pain based on the pain pattern. It can be determined by a thorough analysis of medical history and a detailed neuro-orthopedic examination. Neuroimaging methods should only be interpreted in the context of the clinical picture. In controversial cases, diagnostic blockades with local anesthetics can be performed to confirm the diagnosis.

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A New Stability-Indicating RP-HPLC Method for Simultaneous Quantification of Diacerein and Aceclofenac in Novel Nanoemulgel Formulation and Commercial Tablet Dosage Form in the Presence of their Major Degradation Products Using DoE Approach

Kazi

Dandagi

2023

Journal of Chromatographic Science

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The present study aimed to develop a simple, robust, sensitive and effective stability-indicating reversed-phase high-performance liquid chromatography method for simultaneous quantification of diacerein (DCN) and aceclofenac (ACE) in novel nanoemulgel formulation and commercial tablets in the presence of their main degradation product: rhein (RH) and diclofenac sodium (DLS), respectively. A fractional factorial design was used to screen the crucial independent factors, whereas a central composite design was used for the optimization of the chromatographic conditions. The separation was carried out on Phenomenex C18 column (5 μm, 250 × 4.6 mm), using a mobile phase consisting of phosphate buffer pH 3 (0.1% v/v orthophosphoric acid) and acetonitrile (40:60 v/v) at a flow rate of 1 mL/min with detection at 264 nm. The analytes were exposed to a variety of stress conditions, including heat, alkali, acid, oxidation, photochemical, humidity and hydrolysis. DCN, ACE, RH and DLS were found to have retention times of 4.32 ± 0.15, 5.77 ± 0.07, 8.28 ± 0.20 and 9.10 ± 0.18 min, respectively. The percent recovery for all four analytes was found to be between 98 and 102, and the procedure was discovered to be linear in the range of 0.1–64 μg/mL with R2 value > 0.999. The established method was validated as per ICH guidelines and successfully used to assay DCN and ACE in their combined marketed tablet dosage form and developed nanoemulgel formulation.

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Comparative Study of Safety, Efficacy, and Tolerability of Aceclofenac Versus Diclofenac in Osteoarthritis Patients.

Cited by 3 publications

References 35 publications

Trends in Ambulatory Analgesic Usage after Myocardial Infarction: A Nationwide Cross-Sectional Study of Real-World Data

Trends in Ambulatory Analgesic Usage after Myocardial Infarction: A Nationwide Cross-Sectional Study of Real-World Data

Cervicobrachial syndrome: diagnostic and treatment algorithms

A New Stability-Indicating RP-HPLC Method for Simultaneous Quantification of Diacerein and Aceclofenac in Novel Nanoemulgel Formulation and Commercial Tablet Dosage Form in the Presence of their Major Degradation Products Using DoE Approach

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