Comparative study of silver-sulfadiazine-impregnated collagen dressing versus conventional burn dressings in second-degree burns

Abstract

Background: The advantages of biological skin dressings like collagen are well-known. It makes wound impermeable to bacteria and creates the most physiological interface between the wound surface and the environment. Silver-sulfadiazine-impregnated collagen (SIC) is a type 1 collagen impregnated with silver sulfadiazine (SSD)-loaded alginate microspheres to deliver SSD in a controlled fashion to manage infected burn wounds for an extended period of time with lesser dressing changes. Materials and Methods: In this study, we used SIC for the treatment of second-degree burn wounds in 25 patients and compared with similar burn wounds in 25 patients treated with conventional dressings. Results: For SIC-treated group, we observed improved wound healing in all the patients after 7 days except two patients who required skin grafting, and none of them had any serious complications. For conventionally treated group, improved wound healing was seen in 14 patients, whereas the rest of the patients required prolong dressing or skin grafting. All the patients who were treated with SIC were satisfied with healing of wound and pain relief. Conclusion: Second-degree burn wounds are well-treated with SIC in the form of good healing, control of infection, and reducing pain without any serious complications when compared with conventional dressing.

Evaluation of Bacterial Cellulose Dressing versus Vaseline Gauze in Partial Thickness Burn Wounds and Skin Graft Donor Sites: A Two-Center Randomized Controlled Clinical Study

“…The advances in material sciences have deepened understanding of wound healing and infections and driven the development of new dressings [ 28 ]. Today, a wide variety of dressings are available in the market or have been tested in clinical practice [ 5 , 29 ]. The materials used for dressing include hydrocolloid, polyurethane film, hydrogel, silicon-coated nylon, biosynthetic skin substitute, antimicrobial, fiber, and pads [ 30 ].…”

“…Without the protection of the integumentary system, the burn wound bed is under high risk of bacterial infection, disrupting the natural healing process and leading to poor outcomes. Therefore, wound dressings that can maintain a moist environment and prevent the invasion of pathogens are of great importance to the treatment of second-degree burns [ 5 ]. Clinically effective wound dressings should also possess the features of excellent water retention capacity, ideal biocompatibility, comfort for the patients, and ease of application [ 6 ].…”

Effects of ginsenoside Rb1 on second-degree burn wound healing and FGF-2/PDGF-BB/PDGFR-β pathway modulation

“…Currently, silver sulfadiazine (SSD) is commonly used to prevent burn wound infection and to relieve symptoms during the clinical treatment of second-degree burns [ 10 ]. However, given the adverse effects of these drugs (cytotoxicity, side effects related to antibacterial activity, etc.)…”