The paper presents an experimental investigation on the shear strength of self-piercing rivet connections used in thin-walled steel structures. The test program included specimen variations in the number of rivets in each connection, rivet spacing, end distance, and steel sheet thickness. According to the experimental results, the curve of load-slip, peak load, and failure mechanism for all specimens were analyzed. Parameters of riveting in terms of end distance, spacing, arrangement, length, and thickness difference between connection components were studied on their effects for shearing performances of self-piercing rivet connections. A design method based on the model of transmission dynamics of infectious diseases was proposed for calculating the shear strength of the rivet connections. The strength reduction due to the effect of group rivets was considered in the new method.ii