Comparative study of sub-micrometer polymeric structures: Dot-arrays, linear and crossed gratings generated by UV laser based two-beam interference, as surfaces for SPR and AFM based bio-sensing

Csete, Mária; Sipos, Áron; Kőházi-Kis, A.; Szalai, Anikó; Szekeres, György; Mathesz, Anna; Csákó, T.; Osvay, K.; Bor, Zs.; Penke, B.; Deli, Mária A.; Veszelka, Szilvia; Schmatulla, Alexander; Marti, Othmar

doi:10.1016/j.apsusc.2007.08.020

Cited by 5 publications

(3 citation statements)

References 20 publications

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“…and 66-99 nm for Aβ 1−42 and PPS treatments (8.46 ± 0.69 particles/µm 2 ). Grating coupled surface plasmon resonance investigation was performed on biomolecule-covered polymer-bimetal interfacial gratings in a separate experiment [32]. The forward shift of the secondary resonance minima detected on samples treated by Aβ 1−42 and PPS was smaller than the shift measured after pure Aβ 1−42 attachment.…”

Section: Atomic Force Microscopy Measurementmentioning

confidence: 99%

“…Master grating based two-beam interference (TBI) arrangement was applied to generate sub-micrometer periodic intensity modulation in the beam irradiating the samples [32]. The fourth harmonic of a Nd:YAG laser (lFH = 266 nm, t = 10 ns, f = 10 Hz) impinged on a diffraction grating (PUV 1200, Spectrogon), and the first order diffracted beams were recombined at the sample plane, after propagation trough a fused silica block.…”

Section: Preparation Of Laser-grated Surfaces and Atomic Force Microsmentioning

confidence: 99%

“…The samples were NBK7 substrates evaporated by gold -silver bimetallic layers, and spin-coated by polycarbonate. Samples were treated by s-polarized beams, to produce linear gratings as described earlier [32]. The laser treated surfaces were investigated by atomic force microscopy (AFM) operating in digital pulsed force mode (DPFM, Witec GmbH, Germany).…”

Section: Preparation Of Laser-grated Surfaces and Atomic Force Microsmentioning

confidence: 99%

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Protection of the Blood-Brain Barrier by Pentosan Against Amyloid-β-Induced Toxicity

Deli

Veszelka

Csiszár

et al. 2010

JAD

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Abstract. Endothelial cells of brain capillaries forming the blood-brain barrier play an important role in the pathogenesis and therapy of Alzheimer's disease. Amyloid-β (Aβ) peptides are key pathological elements in the development of the disease. A blood-brain barrier model, based on primary rat brain endothelial cells was used in which the barrier properties were induced by glial cells. The effects of amyloid peptides have been tested on cell viability and barrier functions. Aβ showed toxic effects on primary rat brain endothelial cells measured by MTT dye conversion and the lactate dehydrogenase release. Morphologically cytoplasmic vacuolization, disruption of the structure of cytoplasmic organelles and tight junctions could be observed in brain endothelial cells. Treatment with Aβ1−42 decreased the electrical resistance, and increased the permeability of brain endothelial cell monolayers for both fluorescein and albumin. Serum amyloid P component which stabilizes Aβ fibrils in cortical amyloid plaques and cerebrovascular amyloid deposits significantly potentiated the barrier-weakening effect of Aβ1−42. Sulfated polysaccharide pentosan could decrease the toxic effects of Aβ peptides in brain endothelial cells. It could also significantly protect the barrier integrity of monolayers from damaging actions of peptides. Pentosan modified the size, and significantly decreased the number of amyloid aggregates demonstrated by atomic force microscopy. The present data further support the toxic effects of amyloid peptides on brain endothelial cells, and can contribute to the development of molecules protecting the blood-brain barrier in Alzheimer's disease.

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Section: Atomic Force Microscopy Measurementmentioning

confidence: 99%

Section: Preparation Of Laser-grated Surfaces and Atomic Force Microsmentioning

confidence: 99%

Section: Preparation Of Laser-grated Surfaces and Atomic Force Microsmentioning

confidence: 99%

See 1 more Smart Citation

Protection of the Blood-Brain Barrier by Pentosan Against Amyloid-β-Induced Toxicity

Deli

Veszelka

Csiszár

et al. 2010

JAD

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Comparison of Gold and Silver/Gold Bimetallic Surface for Highly Sensitive Near-infrared SPR Sensor at 1550 nm

et al. 2012

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Niosomes decorated with dual ligands targeting brain endothelial transporters increase cargo penetration across the blood-brain barrier

Mészáros

Porkoláb

Kiss

et al. 2018

European Journal of Pharmaceutical Sciences

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Comparative study of sub-micrometer polymeric structures: Dot-arrays, linear and crossed gratings generated by UV laser based two-beam interference, as surfaces for SPR and AFM based bio-sensing

Cited by 5 publications

References 20 publications

Protection of the Blood-Brain Barrier by Pentosan Against Amyloid-β-Induced Toxicity

Protection of the Blood-Brain Barrier by Pentosan Against Amyloid-β-Induced Toxicity

Comparison of Gold and Silver/Gold Bimetallic Surface for Highly Sensitive Near-infrared SPR Sensor at 1550 nm

Niosomes decorated with dual ligands targeting brain endothelial transporters increase cargo penetration across the blood-brain barrier

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