Comparative study of tetranectin levels in serum and synovial fluid of patients with rheumatoid arthritis, seronegative spondylarthritis and osteoarthritis

Abstract

Tetranectin (TN) was assessed in paired synovial fluid (SF) and serum (S) samples from 27 patients with rheumatoid arthritis (RA), 23 with seronegative spondylarthritis (SSA) and 22 with osteoarthritis (OA). RA patients had a stronger correlation between serum and SF TN and a higher SF/S TN ratio than did SSA and OA patients. Moreover, the SF/S TN ratio exceeded 1 in most RA patients but not in SSA and OA patients, indicating the possibility of intra-articular TN synthesis in RA. A strong correlation of serum and SF TN with known inflammatory markers was observed in RA. The TN/proteinase inhibitors (PIs: alpha1-antitrypsin, alpha2-macroglobulin) molar ratio in SF was lower in RA and SSA patients to a statistically significant degree than in OA patients. In RA, in contrast to SSA and OA, this ratio correlated positively with the SF interleukin-8 (IL-8), responsible for neutrophil recruitment and degranulation, and negatively with erythrocyte sedimentation rate, serum C-reactive protein and fibrinogen, known markers of disease activity. In conclusion, patients with RA showed lower serum TN levels, a higher SF/S TN ratio and a lower SF TN/PI molar ratio than did SSA and OA patients, suggesting the implication of TN in the impaired regulation of fibrinolysis associated with the inflammatory process.

Quantitative proteomic analysis comparing grades ICRS1 and ICRS3 in patients with osteoarthritis

“…Tetranectin is a phosphorylated glycoprotein that has been hypothesized to regulate mineral deposition within the bone (50,51); however, the role of tetranectin in the pathogenesis of OA is currently unclear. Tetranectin has been implicated in the impaired regulation of fibrinolysis and is associated with the inflammatory process in RA (52,53). However, the present study demonstrated that tetranectin expression was decreased in the ICRS3 group compared with the ICRS1 group.…”

Genetic basis of secondary osteoarthritis in dogs with joint dysplasia

“…130 Although the role of tetranectin in the pathogenesis of osteoarthritis is currently unknown, it has been implicated in the impaired regulation of fibrinolysis associated with the inflammatory process in rheumatoid arthritis. 131 α1-Antichymotrypsin is a serine proteinase inhibitor that helps regulate diverse physiologic processes such as coagulation, fibrinolysis, complement activation, angiogenesis, apoptosis, inflammation, and neoplasia and viral pathogenesis 132 and thus potentially can prevent the degradation of connective tissue components. The α-induced protein of TNF is also referred to as TNF-secreted glycoprotein 6 and functions to modulate the interaction between hyaluronan and cell-surface receptor CD44.…”

A multilectin affinity approach for comparative glycoprotein profiling of rheumatoid arthritis and spondyloarthropathy

“…Its overexpression in serum and synovial fluid of RA as compared to osteoarthritis and SpA have been reported earlier [65]. Vitamin D binding protein (GC), a glycoprotein, was found to be >1.5-fold upregulated in RA and has been reported earlier in synovial fluid and serum samples of RA [66,67].…”