Comparative study of the chemical composition and bioactivities of essential oils of fresh and dry seeds from Myoporum insulare R. Br.

Zardi‐Bergaoui, Afifa; Jelizi, Salma; Flamini, Guido; Ascrizzi, Roberta; Jannet, Hichem Ben

doi:10.1016/j.indcrop.2017.10.019

Cited by 32 publications

(24 citation statements)

References 30 publications

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“…Anti‐tyrosinase activities have also been reported for the essential oils from Origanum vulgare, Chenopodium botrys , the fresh and dry fruits of Myoporum insulare , Lavandula angustifolia , the aerial parts of Beta vulgaris , Ocimum basilicum , and Piper magnibaccum …”

Section: Resultsmentioning

confidence: 85%

“…An increased level of melatonin in the skin can lead to skin pigmentation disorders, such as age spots or melasma. 41,42 Anti-tyrosinase activities have also been reported for the essential oils from Origanum vulgare, 13 Chenopodium botrys, 39 the fresh and dry fruits of Myoporum insulare, 43 Lavandula angustifolia, 44 the aerial parts of Beta vulgaris, 45 Ocimum basilicum, 46 and Piper magnibaccum. 47 The inhibition of α-amylase and α-glucosidase can be used to manage blood glucose and to protect against diabetes mellitus, which is a major public health problem in every part of the world.…”

Section: Enzyme-inhibitory Activitymentioning

confidence: 91%

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Composition, and antioxidant and enzyme‐inhibition activities, of essential oils from Satureja thymbra and Thymbra spicata var. spicata

Kırkan

Sarıkürkçü

Amarowicz

2019

Flavour & Fragrance J

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This research sought to characterize the essential oils of Satureja thymbra and Thymbra spicata var. spicata in terms of composition as well as their antioxidant and enzyme‐inhibitory activities. The major components of essential oil derived from S. thymbra were found to be γ‐terpinene (34.67%), carvacrol (32.45%), p‐cymene (11.46%), and β‐caryophyllene (6.85%). In the essential oil derived from T. spicata var. spicata the most abundant compounds were carvacrol (63.23%), γ‐terpinene (18.94%), and p‐cymene (8.31%). The essential oils exhibited antioxidant properties, based on ABTS, DPPH, FRAP, and ORAC assays, as well as antiradical activity against superoxide, nitric oxide, and hydroxyl radicals, and ferrous ion chelating activity. The essential oils were found to have inhibitory effects against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), tyrosinase, and α‐glucosidase. Considering the results obtained, the essential oils from both plants can be used as ingredients in pharmaceuticals or as natural additives in the food industry for promoting health.

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Section: Resultsmentioning

confidence: 85%

Section: Enzyme-inhibitory Activitymentioning

confidence: 91%

Composition, and antioxidant and enzyme‐inhibition activities, of essential oils from Satureja thymbra and Thymbra spicata var. spicata

Kırkan

Sarıkürkçü

Amarowicz

2019

Flavour & Fragrance J

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“…Paraoxonase 1 activity (PON1) in the presence of the AcOEt extract, BuOH extracts and TEBN was determined using paraoxon (1.2 mmol/L) as a substrate in 0.1 m Tris⋅HCl buffer at pH 8.0 containing 2 m m CaCl 2 . 5 μL of the oil were added to be tested for starting the reaction and the increase in absorbance at 405 nm was recorded . PON1 activity was measured by a simple and rapid automated method adapted on Konelab 30 TM (Thermo Electron Corporation, Ruukintie, Finland).…”

Section: Methodsmentioning

confidence: 99%

Characterization of Polar and Non‐Polar Compounds of House Edible Bird's Nest (EBN) from Johor, Malaysia

Lee

Azmi

et al. 2020

Chemistry & Biodiversity

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and Reactivity (LR11ES39), Team: Medicinal Chemistry and Natural Products, Avenue of Environment, 5019 Monastir, TunisiaThis work investigated the polar (PC: protein, amino acid and metabolite) and non-polar (NPC: fatty acid) compounds and bioactivity characteristics of the EBN harvested from the state of Johor in Malaysia. The electrophoretic gels exhibited 15 protein bands (16-173 kD) with unique protein profile. Amino acids analysis by AccQ·Tag method revealed 18 types of amino acids in EBN. Metabolite profiling was performed using High-Performance Liquid Chromatography coupled with Quadrupole Time-of-Flight Mass Spectrometer (HPLC-QTOF/ MS) technique and a total of 54 compounds belonging to different groups were detected and identified. These findings help to uncover the relation of therapeutic activity of EBN. The EBN was further extracted with AcOEt and BuOH. The AcOEt extract was fractionated into three fractions (F 1 À F 3 ), and the high triglyceride content in F 2 was verified by gC-FID. The three groups of fatty acids discovered in EBN are 48.43 % of poly-unsaturated (PUFA), 25.35 % of saturated fatty acids (SFA) and 24.74 % of mono-unsaturated fat (MUFA). This is the first time to report results ofEBN, BuOH, and AcOEt extracts and of fraction F 2 (TEBN) on their analysis for their antioxidant activities by DPPH, ABTS and catalase assay and for their paraoxonase and anti-tyrosinase activities. The results showed that TEBN exhibited the significant bioactivity in all assays. These findings suggest that TEBN is a good source for natural bioactive compounds in promoting body vigor. Current work widened the content of EBN especially on the triglyceride and also marked the content of specific location (Johor, Malaysia) of EBN origin.[a] IC 50 (mg/mL): the concentration at which 50 % is inhibited. [b] TEBN: Triglycerides of EBN. [c] BHT: butylated hydroxytoluene. [d] u/ mg protein: μmol of H 2 O 2 destroyed/min/mg protein. [e] IU: mM/min. Values were expressed as mean � SD (n = 3), Different letters in columns indicate significant differences among fractions at P < 0.05 (LSD test).

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“…[47,48] Cells were seeded at 5 × 10 3 cells/well in 100 μL of growth medium and incubated at 37°C for 24 h to adhere. Cytotoxicity was measured using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) test with slight modifications.…”

Section: Cytotoxic Activitymentioning

confidence: 99%

“…Cytotoxicity was measured using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) test with slight modifications. [47,48] Cells were seeded at 5 × 10 3 cells/well in 100 μL of growth medium and incubated at 37°C for 24 h to adhere. The cells were treated by the isolates and incubated for 48 h; then 10 μL of MTT (5 mg/mL) was added to each well and the incubation lasted 2 h. After this, 100 μL of DMSO were added to each well.…”

Section: Cytotoxic Activitymentioning

confidence: 99%

Caryophyllene Sesquiterpenes from Pulicaria vulgarisGaertn.: Isolation, Structure Determination, Bioactivity and Structure−Activity Relationship

Zardi‐Bergaoui

Znati

Harzallah‐Skhiri

et al. 2019

Chemistry & Biodiversity

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A new caryophyllene, named pulicaryenne A (1), along with four other known caryophyllene derivatives (2, 3, 4 and 5) were isolated from the ethyl acetate extract of aerial parts of Pulicaria vulgaris GAERTN. (Asteraceae). All compounds were isolated for the first time from this species. Compound 2 was identified as a new epimer of a known caryophyllene derivative isolated previously from P. dysenterica. Their structures were established by spectroscopic means including NMR analysis (1D-and 2D-NMR) and ESI-TOF-MS. All compounds were evaluated for their anticholinesterase, antityrosinase and cytotoxic activities against two human cell lines (A549 and HeLa). Results showed that compound 5 exhibited the highest cytotoxic effect against A549 and anticholinesterase activity with IC 50 values of 8.50 � 0.75 and 6.45 � 0.09 μg/mL, respectively. Furthermore, compound 5 showed also an interesting antityrosinase activity with percent inhibition value of 79.0 � 2.5 % at 50 μg/mL. The bioactivity and drug likeness scores of the isolated compounds 1-5 were calculated using Molinspiration software and discussed. These results may suggest that the five caryophyllene derivatives endowed with good biological properties, which could be used as bioactive alternatives in pharmaceutical preparations.

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Comparative study of the chemical composition and bioactivities of essential oils of fresh and dry seeds from Myoporum insulare R. Br.

Cited by 32 publications

References 30 publications

Composition, and antioxidant and enzyme‐inhibition activities, of essential oils from Satureja thymbra and Thymbra spicata var. spicata

Composition, and antioxidant and enzyme‐inhibition activities, of essential oils from Satureja thymbra and Thymbra spicata var. spicata

Characterization of Polar and Non‐Polar Compounds of House Edible Bird's Nest (EBN) from Johor, Malaysia

Caryophyllene Sesquiterpenes from Pulicaria vulgarisGaertn.: Isolation, Structure Determination, Bioactivity and Structure−Activity Relationship

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