Comparative study of the effect of intravenous paracetamol and tramadol in relieving of postoperative pain after general anesthesia in nephrectomy patients

Manne, Venkata Sesha Sai Krishna; Gondi, Srinivasa Rao

doi:10.4103/0259-1162.186619

Cited by 7 publications

(9 citation statements)

References 15 publications

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“…Pain scores significantly decreased only after 60 min, and this was observed up to 6 h and pain scores increased thereafter. 17 In our study, we also observed lower VAS scores in tramadol group compared to paracetamol group in the immediate postoperative period and need of rescue analgesics which was higher in paracetamol group in the immediate postoperative period. Post anaesthetic shivering is a common complication that occurs in up to 60% of patients recovering from general anaesthesia.…”

Section: Discussionsupporting

confidence: 70%

“…In one of the studies, it was observed that drowsiness was found to be higher in tramadol group. 17 In our study, we observed that agitation was more common in paracetamol group and sedation was more common in tramadol group.…”

Section: Discussionmentioning

confidence: 46%

“…19 In one of the studies, in the postoperative period, at baseline, mean VAS score in paracetamol group was 6.30±0.99 as compared to 6.20±1.30 in tramadol group. 20 In another study by they observed that onset of analgesia is faster in tramadol group thus significantly decreases VAS score from 15 min onward, and this was observed up to 3 h. 17 In paracetamol group, the onset of analgesia was slightly delayed. Pain scores significantly decreased only after 60 min, and this was observed up to 6 h and pain scores increased thereafter.…”

Section: Discussionmentioning

confidence: 93%

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Emergence Agitation: Comparison of Paracetamol and Tramadol in Elective Surgery Patients

Thapa,

Shah,

Yadav

et al. 2023

J. Nat. Heart Lung Soc. Nep.

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Background: Post-operative emergence agitation is frequent and self-limiting but at times may present with violent behavior and may result in harm to both patients and caregivers. The objective of this research is to find the incidence of emergence agitation and to compare the effects of paracetamol and tramadol on emergence agitation.Methods: A quasi experimental study was conducted in the Department of Anesthesiology, College of Medical Sciences, Bharatpur, Chitwan, Nepal over a period of three months. One hundred fifty ASA I and II patients aged 18 – 45 years old, posted for elective surgery under general anesthesia were included. Patients were assigned into two equal groups of 75 patients (n=75). At the end of the surgery, group A received inj. tramadol 1mg/kg, just when the surgeon starts skin closure and group B received 15 mg/kg Paracetamol. Time taken for extubation, shivering, Richmond agitation sedation scale (RASS) and sedation and Visual analogue scale (VAS) and need of rescue analgesics were recorded. Results: In paracetamol group, reversal to extubation time was 8.75±3.0 minutes which was higher compared to 6.21±1.84 minutes in tramadol group. Prevalence of shivering was higher in paracetamol group. VAS score in paracetamol group was 5.28±1.03 compared to 4.33±0.82 in tramadol group. Frequency of need of rescue analgesia was higher in paracetamol group. In the immediate postoperative period, agitation was more common. Conclusion: Use of tramadol before extubation reduces the incidence of postoperative emergence agitation, immediate postoperative pain and shivering.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 46%

Section: Discussionmentioning

confidence: 93%

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Emergence Agitation: Comparison of Paracetamol and Tramadol in Elective Surgery Patients

Thapa,

Shah,

Yadav

et al. 2023

J. Nat. Heart Lung Soc. Nep.

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“…The severity of pain ranging from moderate to severe in acute post-operative patients is 15-60%. 7 Different trials have compared narcotic analgesics, nonsteroidal anti-inflammatory drug (NSAID), and neuro axial drugs and blocks. 8 For acute postsurgical pain management after major surgeries, narcotic analgesics are most commonly used.…”

Section: Discussionmentioning

confidence: 99%

Pain Management of Patients under General Anaesthesia Nalbuphine Alone or Nalbuphine with Ketorolac

Shehzad,

Bushra Zafar,

Maqsood Ahmed

et al. 2023

PAFMJ

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Objective: To compare the efficacy of Nalbuphine alone versus Nalbuphine with Ketorolac for the management of pain in for open cholecystectomy under general anaesthesia. Study Design: Comparative prospective study. Place and Duration of Study: Anaesthesia department of CMH, Okara Cantt Pakistan, June 2019- March 2020. Methodology: Patients were divided into two Groups by the lottery method, Group-A, Nalbuphine (.12milligram/kilogram) and Group-B (Nalbuphine .06millig/kilogram+ Ketorolac 15milligram).They were all given standard anesthetic drugs and analgesics in above mentioned dose at the start of surgery. Patients were assessed regarding postoperative pain intensity using the Numerical Pain Rating Scale at 5minute, 30 minutes and 1 hour after shifting to recovery. Rescue analgesia for moderate to severe pain at 30 minutes was documented. Nausea, vomiting and sedation were also noted in both groups. Results: Sedation in Group A was 8(10.7%) as compared in Group-B 4(5.3%).The frequency of nausea and vomiting in Group A and Group-B was 6(8.0%), 4(5.3%), and 5(6.7%), 2(2.7%) respectively. Rescue analgesia being lower in Group-A compared to Group-B which was statistically significant, for moderate to severe pain at 30 minutes after shifting. Group-A 10(13.3%) of cases while Group-B 55(73.3%) of cases producing p-value 0.001.A statistically significant difference regarding pain score between both groups, p-value <0.001. Conclusion: Intravenous Nalbuphine (0.12 mg/kg) was more effective in reducing pain intensity and postoperative analgesic requirements after surgery as compared to Nalbuphine (.6mg/kg)+ Ketorolac (15mg) in combination.

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“…40 In a second randomized study of 100 patients comparing IV acetaminophen to tramadol, tramadol was found to be superior in terms of pain control after nephrectomy. 41 Thus, routine use of IV acetaminophen is not warranted in renal surgery until more data become available.…”

Section: Renal Surgerymentioning

confidence: 99%

Review of Intravenous Acetaminophen for Analgesia in the Postoperative Setting

Tompkins

DiPasquale

Segovia

et al. 2021

The American Surgeon™

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Background Acetaminophen is a non-opioid analgesic commonly utilized for pain control after several types of surgical procedures. Methods This scoping primary literature review provides recommendations for intravenous (IV) acetaminophen use based on type of surgery. Results Intravenous acetaminophen has been widely studied for postoperative pain control and has been compared to other agents such as NSAIDs, opioids, oral/rectal acetaminophen, and placebo. Some of the procedures studied include abdominal, gynecologic, orthopedic, neurosurgical, cardiac, renal, and genitourinary surgeries. Results of these studies have been conflicting and largely have not shown consistent clinical benefit. Conclusion Overall, findings from this review did not support the notion that IV acetaminophen has significant efficacy for postoperative analgesia. Given the limited clinical benefit of IV acetaminophen, especially when compared to the oral or rectal formulations, use is generally not justifiable.

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Comparative study of the effect of intravenous paracetamol and tramadol in relieving of postoperative pain after general anesthesia in nephrectomy patients

Cited by 7 publications

References 15 publications

Emergence Agitation: Comparison of Paracetamol and Tramadol in Elective Surgery Patients

Emergence Agitation: Comparison of Paracetamol and Tramadol in Elective Surgery Patients

Pain Management of Patients under General Anaesthesia Nalbuphine Alone or Nalbuphine with Ketorolac

Review of Intravenous Acetaminophen for Analgesia in the Postoperative Setting

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