Comparative study of the effects of gadolinium chloride and gadolinium – based magnetic resonance imaging contrast agent on freshwater mussel, Dreissena polymorpha

Hanana, Houda; Turcotte, Patrice; André, C.; Gagnon, Christian; Gagné, François

doi:10.1016/j.chemosphere.2017.04.073

Cited by 61 publications

(42 citation statements)

References 53 publications

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“…On the other hand, they observed that gadodiamide did not encourage the production of ROS and that it exhibited antioxidant and proinflammatory effects. 38 In our study, and in support of Hanana et al, we determined that gadodiamide and gadoteric acid caused no significant change in TAS, TOS, or OSI.…”

Section: Discussionsupporting

confidence: 86%

“…Despite this increase in necrotic hepatocytes with gadoteric acid, no difference was observed in HAI grading in terms of AST and ALT levels compared with gadodiamide. The mechanism involved in gadolinium‐induced inflammation is unclear, although gadolinium is reported to stimulate a transmethylation process and chelation in cells and to stimulate mechanisms releasing proinflammatory factors in fibroblasts and from Kupffer cells . In contrast to other toxicity grading methods, physiological and biochemical parameters provide greater support in the method described by Knodell et al, who we used in liver toxicity …”

Section: Discussionmentioning

confidence: 99%

“…In contrast to these studies, Hanana et al recently reported in a study investigating gadolinium together with catalase (CAT), superoxide dismutase (SOD), and glutathione‐S‐transferase (GST) parameters that gadolinium chloride triggers mitochondrial and antiinflammatory pathways. On the other hand, they observed that gadodiamide did not encourage the production of ROS and that it exhibited antioxidant and proinflammatory effects . In our study, and in support of Hanana et al, we determined that gadodiamide and gadoteric acid caused no significant change in TAS, TOS, or OSI.…”

Section: Discussionmentioning

confidence: 99%

“…The mechanism involved in gadoliniuminduced inflammation is unclear, although gadolinium is reported to stimulate a transmethylation process and chelation in cells and to stimulate mechanisms releasing proinflammatory factors in fibroblasts and from Kupffer cells. 37,38 In contrast to other toxicity grading methods, physiological and biochemical parameters provide greater support in the 28 Chen et al showed that gadolinium-induced antioxidant enzymes by accumulating in fish hepatocytes. 6 In addition, Laville et al reported that gadolinium does not give rise to oxidative stress in fish cells.…”

Section: Discussionmentioning

confidence: 99%

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Effects of gadolinium‐based MRI contrast agents on liver tissue

Mercantepe

Tümkaya

Çeliker

et al. 2018

Magnetic Resonance Imaging

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of gadolinium‐based MRI contrast agents on liver tissue

Mercantepe

Tümkaya

Çeliker

et al. 2018

Magnetic Resonance Imaging

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“…() reported that exposure to Gd causes rapid intracellular Gd accumulation, leading to a rise in cellular Ca 2+ levels and the production of endoplasmic reticulum stress creators. However, in their study of the catalase (CAT), superoxidedismutase (SOD) and glutathione‐S‐transferase (GST) parameters, Hanana, Turcotte, André, Gagnon, and Gagné () reported that Gd did not encourage the production of ROS.…”

Section: Discussionmentioning

confidence: 99%

The effect of gadolinium-based contrast agents on rat testis

et al. 2018

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Previous studies have reported that repeated administrations of linear gadolinium-based contrast agents lead to their accumulation in the brain and other tissues in individuals with normal renal functions. The purpose of this prospective animal study was to investigate the effect of multiple administrations of macrocyclic ionic (gadoteric acid) and linear nonionic (gadodiamide) gadolinium-based contrast agents (GBCAs) on rat testis tissue and to compare these molecules in terms of tissue damage. Thirty-two male Sprague-Dawley rats were kept without drugs for 5 weeks after administration of 0.1 mmol mg kg (0.2 ml/kg) gadodiamide and gadoteric acid for 4 days over 5 weeks. Biochemical, histopathological and immunohistochemical changes in testis tissue were evaluated at the end of 10 weeks. When used in repeated clinical doses, gadolinium was observed to increase apoptosis in the Leydig cells of the rat testis, and to increase serum Ca levels and reduce testosterone levels (p < .05). Although the difference was not statistically significant, a greater loss of spermatozoa and immature germinal cell accumulation were observed in the seminiferous tubule lumen in the GBCA groups compared with the control and saline groups (p > .05). Both linear and macrocyclic contrast agents have toxic effects on testis tissue, irrespective of the type of drug.

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Transcriptional Responses as Biomarkers of General Toxicity: A Systematic Review and Meta‐analysis on Metal‐Exposed Bivalves

Ugge

Sahlin

Jonsson

et al. 2023

Enviro Toxic and Chemistry

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Through a systematic review and a series of meta‐analyses, we evaluated the general responsiveness of putative transcriptional biomarkers of general toxicity and chemical stress. We targeted metal exposures performed on bivalves under controlled laboratory conditions and selected six transcripts associated with general toxicity for evaluation: catalase, glutathione‐S‐transferase, heat shock proteins 70 and 90, metallothionein, and superoxide dismutase. Transcriptional responses (n = 396) were extracted from published scientific articles (k = 22) and converted to log response ratios (lnRRs). By estimating toxic units, we normalized different metal exposures to a common scale, as a proxy of concentration. Using Bayesian hierarchical random effect models, we then tested the effects of metal exposure on lnRR, both for metal exposure in general and in meta‐regressions using toxic unit and exposure time as independent variables. Corresponding analyses were also repeated with transcript and tissue as additional moderators. Observed patterns were similar for general and for transcript‐ and tissue‐specific responses. The expected overall response to arbitrary metal exposure was an lnRR of 0.50, corresponding to a 65% increase relative to a nonexposed control. However, when accounting for publication bias, the estimated “true” response showed no such effect. Furthermore, expected response magnitude increased slightly with exposure time, but there was little support for general monotonic concentration dependence with regard to toxic unit. Altogether, the present study reveals potential limitations that need consideration prior to applying the selected transcripts as biomarkers in environmental risk assessment. Environ Toxicol Chem 2023;42:628–641. © 2022 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals LLC on behalf of SETAC.

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Comparative study of the effects of gadolinium chloride and gadolinium – based magnetic resonance imaging contrast agent on freshwater mussel, Dreissena polymorpha

Cited by 61 publications

References 53 publications

Effects of gadolinium‐based MRI contrast agents on liver tissue

Effects of gadolinium‐based MRI contrast agents on liver tissue

The effect of gadolinium-based contrast agents on rat testis

Transcriptional Responses as Biomarkers of General Toxicity: A Systematic Review and Meta‐analysis on Metal‐Exposed Bivalves

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