Comparative Study of the in vitro Antioxidant Properties of Methanolic Extracts of Chromolaena odorata and Ageratum conyzoides used in Wound Healing

Abstract

This study sought to evaluate the potential antioxidative potencies of Chromolaena odorata and Ageratum conyzoides, commonly used herbs in Nigeria for wound first aid and healing. The antioxidant potentials were evaluated by measuring their abilities to scavenge radicals, reduce oxidised iron and quench the formation of lipid peroxides. The findings showed that the extract of Ageratum conyzoides exhibited significantly higher (p<0.05) antioxidant potential than the extract of Chromolaena odorata. The study, therefore, suggests that Ageratum conyzoides has higher potential for therapeutic value than Chromolaena odorata in terms of antioxidant potential.

Medicinal plants and their effects on diabetic wound healing

“…The high concentration of ROS could induce serious tissue damage which could lead to neoplastic transformation, further leading to the impaired healing process by inducing cellular, DNA, proteins, and lipids damages [12,17].…”

“…It was observed that serum albumin level of 3.5 g/dl or more is required for adequate wound healing. Decreased level of protein could negatively affect collagen synthesis thereby impairing wound healing [12,46].…”

“…The exact pathogenesis of poor wound healing in diabetic wound is not adequately understood. However, human and animal studies show impairment in different phases of the wound healing process [2,8,12-15].…”

“…Wound involves a disturbance in the cellular, anatomical, and functional epithelial integrity of the skin consequent to physical, chemical, thermal microbial, or immunological insult; followed by disruption of the structure and function of underlying normal tissue [12,16,17]. The fundamental response in wound healing involves a process of connective tissue repair and is characterized by four overlapping phases such as hemostasis, inflammation, proliferation, and remodeling in which the repair process requires the coordination of different cells, growth factors, and cytokines [18,19].…”

Phytochemical constituents and ethnopharmacological properties of Ageratum conyzoides L.

“…conyzoides extracts may influence structural protein such as collagen in the connective tissues of various parts of the body and also accelerate the growth of epithelial cells at the wound site (Arulprakash et al, ). Oso, Abey, Oyeleke, and Olowookere () have reported the wound healing activity of methanolic extract of A . conyzoides .…”