Medicinal plants and their effects on diabetic wound healing

Oguntibeju, Oluwafemi Omoniyi

doi:10.14202/vetworld.2019.653-663

Cited by 61 publications

(57 citation statements)

References 65 publications

(76 reference statements)

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“…There are bioactive substances with antiseptic and anti-inflammatory properties in some plants and hence are able to heal wounds [ 29 ]. The effects of medicinal plants on wound healing may be linked to the free radical scavenging action of compounds in the extracts acting either singly or synergistically [ 30 ]. Wong et al (2001) reported in their study that amputation could be avoided in 87% of diabetic wound using Chinese herbal medicine [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Plant Leaves Extract Irrigation on Wound Healing in Diabetic Foot Ulcers

Jayalakshmi

Vijayaraghavan

2021

Evidence-Based Complementary and Alternative Medicine

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Purpose. We aimed to evaluate and compare the efficacy of neem leaves extract with normal saline irrigation practice in wound dressing on healing outcome and clinic-physiological parameters among individuals with diabetic foot ulcer (DFU). Methods. A quasiexperimental with repeated measures design was used on two study groups. One group received neem leaf extract wound irrigation and another group received normal saline wound irrigation. Study participants were randomly assigned to each group from 100 DFU individuals. Demographic and clinical data sheets were used to collect baseline information. Random blood sugar and HbA1C measurement was performed on the initial day of visit for all participants. We used the PUSH tool for wound assessment (wound surface area, exudate amount, and tissue type), and clinic physiological parameters (temperature, pulse rate, respiration, blood pressure, wound pain, wound infection, and local warmth) assessment was performed at baseline and then at the end of each week till four weeks were completed. Participants attended a foot clinic every 3rd or 4th day for wound care. Results. Reduction of wound healing score (PUSH score) and other wound variables improved significantly in the neem leaves extract group ( p < 0.001 ). There were no significant changes in the clinic-physiological parameters. Conclusion. Neem leaves extract irrigation for foot ulcers is considered to be very safe as it did not cause any complication systematically during the study. Neem leaf extract solution can be used as an alternative solution for normal saline. Managing DFU requires continuous foot care and early risk identification of ulcer.

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Section: Discussionmentioning

confidence: 99%

Plant Leaves Extract Irrigation on Wound Healing in Diabetic Foot Ulcers

Jayalakshmi

Vijayaraghavan

2021

Evidence-Based Complementary and Alternative Medicine

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“…In addition, ingested phenolic compounds prevent oxidation of polyunsaturated fatty acids [22]. Notably, the dietary phytonutrients and their gut microbial metabolites affect composition of milk and general health of the host [23,24]. O’Conell and Fox [25] noted that phenolic profile of milk greatly changes depending on the type and composition of nutrients consumed by the animals.…”

Section: Discussionmentioning

confidence: 99%

Antioxidative activity and protein profile of skim milk of Gaddi goats and hill cattle of North West Himalayan region

et al. 2019

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Aim: This study was aimed at evaluation of antioxidative activity, protein profile, and vitamins content of milk of Gaddi goats, local non-Gaddi goats, hill cattle, and Jersey crossbred cattle. Materials and Methods: Total phenol, antioxidant activity measured as 2, 2-diphenyl- 1-picrylhydrazyl radical scavenging capacity, total protein, and vitamins were estimated in milk samples by spectrophotometric methods. Milk protein profiles were studied by sulfate-polyacrylamide gel electrophoresis. Results: Total phenol, antioxidant activity, and total protein were higher in indigenous hill cattle skim milk. Average protein content in raw skimmed milk was 1.33±0.01, 1.03±0.02, 0.76±0.05, and 0.81±0.01%, in indigenous hill cattle, Jersey crossbred cattle, non-Gaddi goat, and Gaddi goat, respectively. Three proteins of 19.01, 22.08, and 32.96 kDa were observed in Gaddi goat, but not in non-Gaddi goat skim milk. Furthermore, the above proteins were absent in cattle skim milk. Two proteins of 15.56 and 25.06 kDa were found in local hill and crossbred cattle skimmed milk, but were absent in goat skimmed milk. Vitamin C content was the lowest in Gaddi goat milk and the highest in Jersey crossbred cattle milk. Conclusion: It is envisaged that bioactive metabolites in the milk of Gaddi goats and hill cattle might offer anti-aging and beneficial health effects.

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“…Many properties with sight of a better wound healing process have been obtained such as hemostasis [ 128 , 129 ], antimicrobial [ 126 , 127 ] with cell proliferation inducing effects like electroactivity [ 130 ] and with silica NPs [ 131 ], or finally comprising growth factors for targeted patient's condition such as diabetes [ 132 ]. It is indeed known that diabetes wounds endure a slower healing process than other wounds due to many factors such as a delay in collagen synthesis, but the precise role of most of them are not yet fully understood [ 133 ]. Improved water absorption was also obtained from other 3D-network PU like waterborne PU hydrogels [ 134 ].…”

Section: Conventional (Fossil-based) Pu For Biomedical Applicationsmentioning

confidence: 99%

Biobased polyurethanes for biomedical applications

Wendels

Avérous

2021

Bioactive Materials

241

173

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Polyurethanes (PUs) are a major family of polymers displaying a wide spectrum of physico-chemical, mechanical and structural properties for a large range of fields. They have shown suitable for biomedical applications and are used in this domain since decades. The current variety of biomass available has extended the diversity of starting materials for the elaboration of new biobased macromolecular architectures, allowing the development of biobased PUs with advanced properties such as controlled biotic and abiotic degradation. In this frame, new tunable biomedical devices have been successfully designed. PU structures with precise tissue biomimicking can be obtained and are adequate for adhesion, proliferation and differentiation of many cell's types. Moreover, new smart shape-memory PUs with adjustable shape-recovery properties have demonstrated promising results for biomedical applications such as wound healing. The fossil-based starting materials substitution for biomedical implants is slowly improving, nonetheless better renewable contents need to be achieved for most PUs to obtain biobased certifications. After a presentation of some PU generalities and an understanding of a biomaterial structure-biocompatibility relationship, recent developments of biobased PUs for non-implantable devices as well as short- and long-term implants are described in detail in this review and compared to more conventional PU structures.

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Medicinal plants and their effects on diabetic wound healing

Cited by 61 publications

References 65 publications

Plant Leaves Extract Irrigation on Wound Healing in Diabetic Foot Ulcers

Plant Leaves Extract Irrigation on Wound Healing in Diabetic Foot Ulcers

Antioxidative activity and protein profile of skim milk of Gaddi goats and hill cattle of North West Himalayan region

Biobased polyurethanes for biomedical applications

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