Comparative study of the LC–MS/MS and UPLC–MS/MS for the multi-residue analysis of quinolones, penicillins and cephalosporins in cow milk, and validation according to the regulation 2002/657/EC

Abstract

The aim of this study was to develop and validate an analytical method to simultaneously determine European Union-regulated ȕ-lactams (penicillins and cephalosporins) and quinolones in cow milk. The procedure involves a new solid phase extraction (SPE) to clean-up and pre-concentrate the three series of antibiotics before analysis by liquid chromatography-tandem mass spectrometry (LC-MS/MS) and ultrahigh-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). LC-MS/MS and UPLC-MS

High resolution mass spectrometry in the identification of transformation products and metabolites from β-lactam antibiotics in thermally treated milk

“…A previously described sample treatment procedure [20] was applied to milk samples. Thus, to 2 g of milk, 2 mL of Milli-Q water and 0.5 mL of phosphate solution (0.1 mol L −1 at pH 10) were added.…”

Comparison Between the Amount of Penicillin G Residue in Raw and Pasteurized Milk in Iran

“…In order to improve the milk quality and healthiness, it should be free of every physical, biological and chemical contaminations. For instance, different kinds of antibiotics, most typically the Benzylpenicillin (2), which can basically cause numerous problems to the dairy industry (3)(4)(5).…”

Quechers methodologies as an alternative to solid phase extraction (SPE) for the determination and characterization of residues of cephalosporins in beef muscle using LC–MS/MS

“…In particular, LC-MS or LC/MS/MS are the preferred techniques in the determination of ␤-lactams residues. A number of authors have reported multiresidue methods for the determination of ␤-lactams in animal tissues or milk [6,[9][10][11][12][13][14][15][16][17], but only a few of these methods include some cephalosporins as targets of study [9][10][11]16,17].…”