Comparative study of the mechanical behaviour of a cyanoacrylate and a bioadhesive

Abstract

We compared the mechanical resistance of 18 samples of calf pericardium bonded with a 100 mm2 overlap, by two types of glues: a cyanoacrylate (Loctite 4011) and a bioadhesive (BioGlue). Comparative tensile testing was also carried out in 40 paired samples, 20 bonded with the cyanoacrylate and 20 unbonded controls. The findings at rupture showed a greater resistance of the calf pericardium glued with cyanoacrylate, with a mean tensile strength of 0.15 MPa vs. 0.04 MPa for the biological glue (p= 0.000). They also demonstrated a loss of resistance of the samples bonded with cyanoacrylate when compared with that of the unbonded other halves of the pairs: 0.20 MPa and 0.27 MPa vs. 19.47 MPa and 24.44 MPa (p < 0.001). The method of selection by means of paired samples made it possible to establish the equations that relate the stress and strain, or deformation, with excellent coefficients of determination (R2). These equations demonstrate the marked elastic behaviour of the bonded samples. Moreover, these findings show the cyanoacrylate to be superior to the biological glue, leading to the examination of the compatibility, inalterability over time and mechanical behaviour of the cyanoacrylate in sutured samples, as well as the study of the anisotropy of the biomaterial when bonded with a bioadhesive.

Histomorphometric analysis of the repair process of autogenous bone grafts fixed at rat calvaria with cyanoacrylate

“…This was demonstrated by the fact that the bone fragment remained stable in both studied periods, confirming the good adhesive capacity of the ethyl-CA, which has been shown in previous studies 11,23,27 .…”

“…Ethyl-CA, which is a short chain CA, was one of the first adhesives to be tested for medical use, presenting excellent adhesive strength 11 . However, its apparent toxicity to soft tissues conducted the researches for adhesives of longer chain, such as butyl and octyl-CA, which present higher biocompatibility 9 .…”

Glubran2 Surgical Glue: In Vitro Evaluation of Adhesive and Mechanical Properties

“…Each sample was obtained bonding two strips of similar thickness [2]. For all the tests, the gluing area was delimited by petroleum jelly and the glue was uniformly applied onto one of the strips of the couple; after overlapping the second strip, a load was applied for 10 min in order to allow complete polymerization.…”

“…In order for a glue to be used to secure a structure, together with sutures or by itself, it must possess adequate mechanical properties [2]: clinical performance of a sealant, in fact, is strongly influenced by its physical properties, such as elasticity and tensile and adhesive strength to biologic tissues.…”

Nanomaterials as Tissue Adhesives

“…Therefore, the efforts in this field have focused on the development of new medical adhesives and improving the existing ones in accordance with defined design principles. A typical tissue adhesive for wound healing should fulfill certain criteria to find wide applicability in medical and surgical practices (Bouten et al, 2014;Páez et al, 2004):…”