Comparative study of the pharmacokinetics and bioaccessibility of orthophen suppositories

Abstract

The pharmacokinetic characteristics of 0.05 g orthophen rectal suppositories produced by the Semashko MosKhimFarmPreparaty company have been studied in comparison to analogous suppositories with a modified composition based on tallow with an additive of 5% of poly(ethylene oxide) (PEO-400), which have been developed at the Pyatigorsk State Pharmaceutical Academy in collaboration with the AltaiVitaminy joint-stock company. It is established that the two medicinal preparations are bioequivalent. 518 0091-150X/05/3910-0518