Comparative study of tissue reactions to calcium phosphate ceramics among cancellous, cortical, and medullar bone sites in rabbits

Lu, Jianxi; Gallur, A.; Flautre, B.; Anselme, Karine; Descamps, M.; Thierry, B.; Hardouin, Pierre

doi:10.1002/(sici)1097-4636(19981205)42:3<357::aid-jbm3>3.0.co;2-i

Cited by 178 publications

(85 citation statements)

References 12 publications

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“…[14] Most of the β-TCP gets biodegraded by both osteoclastic activities subsequent to the particle disaggregation and/or chemical dissolution of the molecule in the calcium and phosphate components followed by replacement with healthy bone. [151617] ATG resorbs within 4–6 months after grafting. The remodeling process with new bone formation continues up to 1–2 years.…”

Section: Discussionmentioning

confidence: 99%

Alveolar ridge preservation using autogenous tooth graft versus beta-tricalcium phosphate alloplast: A randomized, controlled, prospective, clinical pilot study

Joshi¹,

Dani²,

Khedkar³

2016

J Indian Soc Periodontol

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Background:A randomized, prospective clinical, radiographical, and histological study was conducted to evaluate healing after alveolar ridge preservation technique using two different graft materials, namely, a novel autogenous graft material i. e., autogenous tooth graft (ATG) and beta-tricalcium phosphate (β-TCP) alloplast.Materials and Methods:Fifteen patients undergoing extraction of at least three teeth were selected. Atraumatic extractions were performed. Of the three extraction sockets, one was grafted with ATG, other with β-TCP, and the third was left ungrafted. Cone-beam computed tomography scans were taken immediately after grafting and 4 months postoperatively to check the changes in alveolar crest height and width at all the sites. Three patients in whom implant placement was done after complete healing; bone samples were harvested using a 3 mm diameter trephine during osteotomy preparation from both the ridge preserved sites and studied histologically.Results:There was a statistically significant difference when the changes in width and height of alveolar crest were compared within all the three groups (P < 0.05). Among three sites, ATG-grafted sites showed the most superior results with a minimal reduction in alveolar crest height and width. Histological analysis also showed the same trend with more new bone formation at ATG-grafted sites as compared to β-TCP-grafted sites.Conclusion:Postextraction, ridge preservation leads to more predictable maintenance of alveolar ridge height and width. ATG as compared to β-TCP provided superior results. Based on this, we conclude that ATG material can serve as a better alternative to conventional bone graft materials.

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Section: Discussionmentioning

confidence: 99%

Alveolar ridge preservation using autogenous tooth graft versus beta-tricalcium phosphate alloplast: A randomized, controlled, prospective, clinical pilot study

Joshi¹,

Dani²,

Khedkar³

2016

J Indian Soc Periodontol

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“…Those will further lead to different degradation behaviors for the susceptible biodegradable Mg implants. Additionally, the local blood flow conditions were different between the cortical and trabecular bone [20]. The sufficient blood supply of the trabecular bone may accelerate the exposure of biomaterials to body fluids and multinucleate cells, and thus the degradation rate of Mg alloy will decrease from the implantation sites in the following sequence: soft tissue, less trabecular bone area, more trabecular bone area and cortical bone.…”

Section: Discussionmentioning

confidence: 99%

Shape and Site Dependent in Vivo Degradation of Mg-Zn Pins in Rabbit Femoral Condyle

Han

Tan

Zhang³

et al. 2014

IJMS

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A type of specially designed pin model of Mg-Zn alloy was implanted into the full thickness of lesions of New Zealand rabbits’ femoral condyles. The recovery progress, outer surface healing and in vivo degradation were characterized by various methods including radiographs, Micro-CT scan with surface rendering, SEM (scanning electron microscope) with EDX (Energy Dispersive X-ray analysis) and so on. The in vivo results suggested that a few but not sufficient bridges for holding force were formed between the bone and the implant if there was a preexisting gap between them. The rapid degradation of the implantation in the condyle would result in the appearance of cavities. Morphological evaluation of the specially designed pins indicated that the cusp was the most vulnerable part during degradation. Furthermore, different implantation sites with distinct components and biological functions can lead to different degradation rates of Mg-Zn alloy. The rate of Mg-Zn alloy decreases in the following order: implantation into soft tissue, less trabecular bone, more trabecular bone, and cortical bone. Because of the complexities of in vivo degradation, it is necessary for the design of biomedical Mg-Zn devices to take into consideration the implantation sites used in clinics.

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“…The chemical alterations in the environment around the implanted materials result in pH level elevation or decrease and can potentially cause erosion. The physical characteristics, chemical composition, crystal structure, and site of implantation play an important role in the biological behavior of CaPs [26,27]. …”

Section: Introductionmentioning

confidence: 99%

Mechanisms of in Vivo Degradation and Resorption of Calcium Phosphate Based Biomaterials

et al. 2015

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Calcium phosphate ceramic materials are extensively used for bone replacement and regeneration in orthopedic, dental, and maxillofacial surgical applications. In order for these biomaterials to work effectively it is imperative that they undergo the process of degradation and resorption in vivo. This allows for the space to be created for the new bone tissue to form and infiltrate within the implanted graft material. Several factors affect the biodegradation and resorption of calcium phosphate materials after implantation. Various cell types are involved in the degradation process by phagocytic mechanisms (monocytes/macrophages, fibroblasts, osteoblasts) or via an acidic mechanism to reduce the micro-environmental pH which results in demineralization of the cement matrix and resorption via osteoclasts. These cells exert their degradation effects directly or indirectly through the cytokine growth factor secretion and their sensitivity and response to these biomolecules. This article discusses the mechanisms of calcium phosphate material degradation in vivo.

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Comparative study of tissue reactions to calcium phosphate ceramics among cancellous, cortical, and medullar bone sites in rabbits

Cited by 178 publications

References 12 publications

Alveolar ridge preservation using autogenous tooth graft versus beta-tricalcium phosphate alloplast: A randomized, controlled, prospective, clinical pilot study

Alveolar ridge preservation using autogenous tooth graft versus beta-tricalcium phosphate alloplast: A randomized, controlled, prospective, clinical pilot study

Shape and Site Dependent in Vivo Degradation of Mg-Zn Pins in Rabbit Femoral Condyle

Mechanisms of in Vivo Degradation and Resorption of Calcium Phosphate Based Biomaterials

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