Comparative study of transdermal drug delivery systems of resveratrol: High efficiency of deformable liposomes

Tosato, Maira Gaspar; Girón, Julie Viviana Maya; Martin, Aírton Abrahão; Tippavajhala, Vamshi Krishna; Mele, Mónica Alicia Fernández Lorenzo de; Dicelio, Lelia E.

doi:10.1016/j.msec.2018.04.073

Cited by 41 publications

(18 citation statements)

References 43 publications

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“…Anthralin solubility in ethanol probably facilitated its leakage from the ethosomes leading to lower encapsulation efficiency compared with liposomes. Similar effects were previously observed for other drugs incorporated into liposomes and ethosomes [48,49].…”

Section: Effect Of Ethanol Concentration On the Drug Encapsulation Efsupporting

confidence: 88%

Liposomal and Ethosomal Gels for the Topical Delivery of Anthralin: Preparation, Comparative Evaluation and Clinical Assessment in Psoriatic Patients

2020

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To enhance anthralin efficacy against psoriasis and reduce its notorious side effects, it was loaded into various liposomal and ethosomal preparations. The nanocarriers were characterized for drug encapsulation efficiency, size, morphology and compatibility between various components. Optimum formulations were dispersed in various gel bases and drug release kinetics were studied. Clinical efficacy and safety of liposomal and ethosomal Pluronic®F-127 gels were evaluated in patients having psoriasis (clinicaltrials.gov identifier is NCT03348462). Safety was assessed by recording various adverse events. Drug encapsulation efficiency ≥97.2% and ≥77% were obtained for liposomes and ethosomes, respectively. Particle sizes of 116 to 199 nm and 146 to 381 nm were observed for liposomes and ethosomes, respectively. Fourier-Transform infrared (FT-IR) spectroscopy and differential scanning calorimetry (DSC) studies confirmed the absence of interaction between anthralin and various nanocarrier components. Tested gel bases showed excellent ability to sustain drug release. At baseline, the patients had a median Psoriasis Area and Severity Index (PASI) of 3.4 for liposomes and 3.6 for ethosomes without significant difference. After treatment, mean PASI change was −68.66% and −81.84% for liposomes and ethosomes, respectively with a significant difference in favor of ethosomes. No adverse effects were detected in both groups. Anthralin ethosomes could be considered as a potential treatment of psoriasis.

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Section: Effect Of Ethanol Concentration On the Drug Encapsulation Efsupporting

confidence: 88%

Liposomal and Ethosomal Gels for the Topical Delivery of Anthralin: Preparation, Comparative Evaluation and Clinical Assessment in Psoriatic Patients

2020

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“…71 Other properties have also been measured. Tosato et al- 72 assessed the thermotropic behavior of lipid bilayers for incorporating active compounds within a temperature ranging from −75°C to 75°C. The addition of 15 mg of resveratrol to deformable liposomes increased the enthalpy from 260 to 340 J/g suggesting that lipids in deformable liposomes have an orderly arrangement, such as the bilayer does not present major changes.…”

Section: Physicochemical Properties Of Liposomesmentioning

confidence: 99%

<p>Development, Characterization and Use of Liposomes as Amphipathic Transporters of Bioactive Compounds for Melanoma Treatment and Reduction of Skin Inflammation: A Review</p>

Castañeda-Reyes

Perea-Flores

Dávila-Ortíz

et al. 2020

IJN

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The skin is the largest organ in the human body, providing a barrier to the external environment. It is composed of three layers: epidermis, dermis and hypodermis. The most external epidermis is exposed to stress factors that may lead to skin conditions such as photo-aging and skin cancer. Some treatments for skin disease utilize the incorporation of drugs or bioactive compounds into nanocarriers known as liposomes. Liposomes are membranes whose sizes range from nano to micrometers and are composed mostly of phospholipids and cholesterol, forming similar structures to cell membranes. Thus, skin treatments with liposomes have lower toxicity in comparison to traditional treatment routes such as parenteral and oral. Furthermore, addition of edge activators to the liposomes decreases the rigidity of the bilayer structure making it deformable, thereby improving skin permeability. Liposomes are composed of an aqueous core and a lipidic bilayer, which confers their amphiphilic property. Thus, they can carry hydrophobic and hydrophilic compounds, even simultaneously. Current applications of these nanocarriers are mainly in the cosmetic and pharmaceutic industries. Nevertheless, new research has revealed promising results regarding the effectiveness of liposomes for transporting bioactive compounds through the skin. Liposomes have been well studied; however, additional research is needed on the efficacy of liposomes loaded with bioactive peptides for skin delivery. The objective of this review is to provide an up-to-date description of existing techniques for the development of liposomes and their use as transporters of bioactive compounds in skin conditions such as melanoma and skin inflammation. Furthermore, to gain an understanding of the behavior of liposomes during the process of skin delivery of bioactive compounds into skin cells.

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“…A cationic CTAB noisome loaded with gallic acid has a demonstrated good stability and an anti‐ageing activity in a previous study Ethosome: a malleable vesicular carrier containing high concentration of ethanol component to promote delivery into deeper skin layers. An ethosome‐mediated apigenin delivery demonstrated an enhanced skin deposition compared with liposomes and deformable liposomes . Deformable liposome: a lipid vesicle with a deformable bilayer structure generated by the incorporation of surfactant edge activators, having the attribute of high deformability across the skin barrier . Glycerosome: a lipid vesicle composed of glycerol as edge activator to modify the fluidity of the bilayer structure thus improving the transdermal delivery of active ingredients (e.g. quercetin) . Hyalurosome: a phospholipid nanovesicle immobilized by sodium hyaluronate and has demonstrated higher ability than conventional liposome in promoting skin deposition and therapeutic efficacy of low bioavailable compounds, such as curcumin and the phenolic extracts from liquorice ( Glycyrrhiza glabra L.) roots . Transfersome: an ultradeformable phospholipid vesicle composed of surfactant or edge activator and capable of improving the dermal deposition of hydrophilic ingredients (i.e.…”

Section: Vesicle Systemmentioning

confidence: 99%

Encapsulating plant ingredients for dermocosmetic application: an updated review of delivery systems and characterization techniques

Yang

Liu

Han

et al. 2020

Intern J of Cosmetic Sci

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Today, there is a rising demand and ongoing search for novel plant-derived phytochemicals in the cosmetic market owing to the growing consumer expectations worldwide for green and natural health products. Various plant ingredients, including polyphenols, oils, volatile oils, vitamins and other herbal extracts, have been extensively used in herbal cosmetics. Recent advances in encapsulation technologies have greatly improved their chemical stability, biocompatibility, skin permeability and dermocosmetic efficiency when applied topically. This comprehensive review summarizes the up-to-date information on encapsulated plant ingredients tailored for dermocosmetic application with a focus on the development of novel delivery systems. An overview of the commonly used techniques for carrier characterization, performance-related properties and toxicological evaluation is also included, which might provide guidance for researchers to select or develop appropriate assay systems. PolyphenolsPolyphenols are secondary metabolites in plants, and the presence of the array of phenolic hydroxyl groups makes them potent free radical scavengers and antioxidants, which are favoured in antiageing cosmetics [1]. Encapsulation techniques are primarily employed to stabilize the easily reducible polyphenolic compounds during storage and processing, thereby enabling their cosmetic/ pharmaceutical uses. A good example is quercetin, a flavonoid from Sophora japonica L. with a pronounced antioxidative and anti-inflammatory activity but with poor water solubility and low skin

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Comparative study of transdermal drug delivery systems of resveratrol: High efficiency of deformable liposomes

Cited by 41 publications

References 43 publications

Liposomal and Ethosomal Gels for the Topical Delivery of Anthralin: Preparation, Comparative Evaluation and Clinical Assessment in Psoriatic Patients

Liposomal and Ethosomal Gels for the Topical Delivery of Anthralin: Preparation, Comparative Evaluation and Clinical Assessment in Psoriatic Patients

<p>Development, Characterization and Use of Liposomes as Amphipathic Transporters of Bioactive Compounds for Melanoma Treatment and Reduction of Skin Inflammation: A Review</p>

Encapsulating plant ingredients for dermocosmetic application: an updated review of delivery systems and characterization techniques

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