Comparative study on the ALA photodynamic effects of human glioma and meningioma cells

Tsai, Jui‐Chang; Hsiao, Yi-Yun; Teng, Lee‐Jene; Chen, Chin‐Tin; Kao, Ming‐Chien

doi:10.1002/(sici)1096-9101(1999)24:4<296::aid-lsm7>3.3.co;2-6

Cited by 12 publications

(13 citation statements)

References 20 publications

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“…Another cell line, KT21-MG1, originated from an irradiated malignant meningioma of the falx, but original tumor and xenografts did not show typical meningothelial differentiation except for monosomy 22 and scant desmosomes in xenografts. 2 Other meningioma cell lines have been sporadically used, such as CH-157NN, 27,28 …”

Section: Previously Published Meningioma Cell Linesmentioning

confidence: 99%

Establishment of a benign meningioma cell line by hTERT-mediated immortalization

Püttmann

Senner

Braune

et al. 2005

Laboratory Investigation

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Meningioma represents the most common intracranial tumor, but well-characterized cell lines derived from benign meningiomas are not available. A major reason for the lack of benign tumor cell lines is senescence of nonmalignant cells in vitro, while malignant cells are often immortal. We have developed a meningioma cell line by retrovirally transducing primary cells derived from a human WHO grade I meningothelial meningioma with the human telomerase reverse transcriptase (hTERT) gene, which enables bypassing cellular senescence. Five clones have been cultured for more than 21 months so far, while corresponding nontransfected cells ceased proliferation within 3 months. Quantitative RT-PCR and a telomeric repeat amplification protocol (TRAP) assay revealed high hTERT mRNA levels and high telomerase activity in all transduced populations, while nontransduced cells were negative. The average telomere size of transduced cells was considerably longer than that of parental cells and the biopsy specimen. One clone, designated Ben-Men-1, was characterized in more detail, and exhibited typical cytological, immunocytochemical, ultrastructural and genetical features of meningioma, including whorl formation, expression of epithelial membrane antigen, desmosomes and interdigitating cell processes, as well as À22q. Following subdural transplantation into nude mice, tumor tissue with typical histological features of meningothelial meningioma was found. We conclude that Ben-Men-1 represents an immortalized yet differentiated cell line useful for biological and therapeutical studies on meningioma.

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Section: Previously Published Meningioma Cell Linesmentioning

confidence: 99%

Establishment of a benign meningioma cell line by hTERT-mediated immortalization

Püttmann

Senner

Braune

et al. 2005

Laboratory Investigation

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“…Clonogenic assays used the well-characterized human meningioma cell lines, CH157-MN and IOMM-Lee (Lee, 1990;Tsai et al, 1995;Tsai et al, 1999). Cells were transfected with equimolar amounts of pcDNA3.myc (vector), pcDNA3.-myc.DAL-1, pcDNA3.myc.F356Q, pcDNA3.myc.F359Y, or pcDNA3.myc.H370Y.…”

Section: Clonogenic Assaymentioning

confidence: 99%

Disruption of 14-3-3 binding does not impair Protein 4.1B growth suppression

2004

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“…In vitro experiments with gliomas cell lines and HpD showed that prePDT treatment with EGF had no effect, while postPDT treatment decreased the toxicity [161]. Similarly, pretreatment with EGF, basic fibroblast growth factor, or PDGF had not effect on ALA or proto IX PDT in glioma cells [162].…”

Section: Vasoactive Substancesmentioning

confidence: 95%

Platelets, photosensitizers, and PDT

Senge

Radomski

2013

Photodiagnosis and Photodynamic Therapy

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SummaryPhotodynamic therapy (PDT) has both direct cell and indirect vascular effects. Both are well established and the latter has given rise to specifically target angiogenesis in PDT treatments. While the vascular effects are well understood, further advances in antiangiogenesis require a detailed understanding of PDT effects at the microvasculature level. Although some of the earliest investigations of PDT noted effects on platelet aggregation the importance of their interaction with endothelial cells and the crucial role of various signaling pathways is only now emerging. This review aims to give a general overview of PDT related studies on platelets, vascular effects, and their interaction with endothelial cells to indicate the potential for studies in this area.Abbreviations: ALA --aminolevulinic acid; AMD -age-related macular degeneration; ANET -anti-neovascular therapy; BGF -basic fibroblast growth factor; DHEdihaematoporphyrin ether; EDRF -endothelium-derived relaxing factor; epithelial growth factor -EGF; HIF-1 -hypoxia-inducible factor 1; HpD -haematoporphyrin derivative; IL -interleukin; PAF -platelet activating factor; PDT -photodynamic therapy; PS -photosensitizer; transforming growth factor 1 -TGF-1; TNF -tumor necrosis factor.

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Comparative study on the ALA photodynamic effects of human glioma and meningioma cells

Cited by 12 publications

References 20 publications

Establishment of a benign meningioma cell line by hTERT-mediated immortalization

Establishment of a benign meningioma cell line by hTERT-mediated immortalization

Disruption of 14-3-3 binding does not impair Protein 4.1B growth suppression

Platelets, photosensitizers, and PDT

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