Comparative study on the effects of <scp>EGF</scp> and b<scp>FGF</scp> on the healing of human large traumatic perforations of the tympanic membrane

Zhengcai-Lou,; Zihan-Lou,; Yongmei-Tang,

doi:10.1002/lary.25715

Cited by 46 publications

(37 citation statements)

References 20 publications

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“…When the waiting time for spontaneous perforation healing is long, the risk for otitis media was increased 10. In addition, there is an evidence that the site of perforation and blood supply also affect the spontaneous healing of TM perforations 11. Therefore, it is recommended that large TM perforations need active therapy.…”

Section: Discussionmentioning

confidence: 99%

Management of traumatic tympanic membrane perforation: a comparative study

Gao¹,

Li²,

Hu³

et al. 2017

TCRM

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This prospective study was conducted to evaluate the efficacy of sea buckthorn oil patches in treating traumatic tympanic membrane (TM) perforations. We enrolled 370 patients with traumatic TM perforations of different sizes. These patients were randomly assigned to control group and treatment group. In the treatment group, a sterile cotton patch with sea buckthorn oil was used to cover the TM perforations. In the control group, patients were treated with a sterile cotton patch. The healing rate and time were compared between the two groups. We found that the overall healing rate was significantly higher in the treatment group than in the control group. For middle and large TM perforations, sea buckthorn oil treatment led to a significant increase in the healing rate. At 2 months after injury, the duration of healing was, generally, shorter in the treatment group than in the control group (P<0.05). In conclusion, sea buckthorn oil patches are effective in treating middle and large TM perforations, which results in increased healing rates and decreased healing time.

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Section: Discussionmentioning

confidence: 99%

Management of traumatic tympanic membrane perforation: a comparative study

Gao¹,

Li²,

Hu³

et al. 2017

TCRM

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“…Some clinical studies found that topical application of growth factors (i.e., epidermal growth factor [EGF] and basic fibroblast growth factor [bFGF]) without the patch significantly shortened the closure time and improved the closure rate of large traumatic TMPs. [5][6][7] A previous experimental study 8 also suggested that direct application of bFGF increased closure time compared to bFGF combined with the patch. Other clinical studies demonstrated 9,10 that topical application of ofloxacin otic drops without a patch significantly shortened the closure time of traumatic TMPs.…”

Section: Letter To the Editormentioning

confidence: 96%

In reference to Tympanic membrane repair using silk fibroin and acellular collagen scaffolds

Zhengcai-Lou

2016

The Laryngoscope

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“…During the early stages of wound healing, the overexpression of inflammatory factors, such as interleukin (IL)-6 and tumor necrosis factor (TNF)-α (14,15), severely impairs the formation of granulation tissue and further delays wound healing. However, a number of studies have revealed that growth factors, including vascular endothelial growth factor (VEGF) (2,4,16), epidermal growth factor (17,18) and transforming growth factor-β (TGF-β) (19,20), serve an important role in the promotion of wound healing.…”

Section: Introductionmentioning

confidence: 99%

Low‑frequency ultrasound enhances vascular endothelial growth factor expression, thereby promoting the wound healing in diabetic rats

et al. 2019

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Diabetes is a chronic metabolic disease with a high prevalence worldwide, which typically delays or impairs wound healing, potentially causing death. Low-frequency ultrasound treatment promotes the repair of various injuries and may promote wound healing. The aim of the present study was to determine whether low-frequency ultrasound can accelerate wound healing, as well as investigate its effects on the expression of vascular endothelial growth factor (VEGF), transforming growth factor (TGF)-β1, interleukin (IL)-6 and tumor necrosis factor (TNF)-α in diabetic rats. A total of 45 Wistar rats were intraperitoneally injected with 1% streptozocin following intraperitoneal injection of pentobarbital sodium anesthesia. Subsequently an incision wound was created in the skin of back. The area of the wound was recorded to calculate the rate of wound healing. The expression of VEGF and TGF-β1 was determined via immunohistochemical analysis and their mRNA and protein levels were measured via reverse transcription-quantitative PCR analysis. The results revealed that when compared with the control group, low-frequency ultrasound treatment significantly increased wound healing rate in diabetic rats and markedly increased the mRNA and protein levels of VEGF and TGF-β1. US treatment also reduced the mRNA and protein levels of TNF-α and IL-6. In conclusion, the results of the present study indicated that low-frequency ultrasound promotes the expression of VEGF and TGF-β1, and inhibits the expression of IL-6 and TNF-α, thereby promoting wound healing in diabetic rats.

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Comparative study on the effects of EGF and bFGF on the healing of human large traumatic perforations of the tympanic membrane

Abstract: Both EGF and bFGF can accelerate the closure of human large traumatic TMPs. The healing outcomes among the two growth factors were not significantly different.

Cited by 46 publications

References 20 publications

Management of traumatic tympanic membrane perforation: a comparative study

Management of traumatic tympanic membrane perforation: a comparative study

In reference to Tympanic membrane repair using silk fibroin and acellular collagen scaffolds

Low‑frequency ultrasound enhances vascular endothelial growth factor expression, thereby promoting the wound healing in diabetic rats

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