Management of traumatic tympanic membrane perforation: a comparative study

Gao, Tianxi; Li, Xiaoli; Hu, Juan; Ma, Weijun; Li, Jingjing; Shao, Na; Wang, Zhenghui

doi:10.2147/tcrm.s139631

Cited by 17 publications

(17 citation statements)

References 19 publications

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“…7 The mean age and commonest age of presentation of this study is also comparable with results of Al-Juboori from Iraq and Gao and colleagues from china and some other studies. 8,9 In current study amongst the cause of TTMP, slap trauma was most common (70.2%, n-80), subsequently trauma due to blast was found in 17 patients (14.9%), which is keeping with results of Ahluwalia, Al-Juboori, Singh, Irfan, Rai, who also reported that TTMP was mainly due to slap trauma to the ears. 7,8,[10][11][12] However etiologic factors of this study differs from that of, Ravi, Dawood, Sannigrahi, and Al-Obiedi where traumatic tympanic perforation was predominantly caused by blast injuries while in one study road traffic accidents was main cause of tympanic membrane perforation.…”

Section: Discussionsupporting

confidence: 88%

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Aftermath of traumatic tympanic membrane perforation: Our findings at a tertiary care hospital in Pakistan

Wahid¹,

Saleem²,

Muhammad³

et al. 2021

Pak J Med Sci

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Objectives: To determine the outcome of traumatic tympanic membrane perforation in a teaching hospital at Peshawar, Pakistan. Methods: This prospective observational study was performed in the Department of ENT and Head and Neck Surgery, MTI/LRH, Peshawar, Pakistan from January 2016 to December 2019 after approved from Institutional Research and Ethical Board. All consented patients fulfilling inclusion criteria were enrolled. Sample size was calculated 114 using online sample size calculator (OpenEpi). Every patient was evaluated properly, subsequently otoscopy and PTA was performed. Required information was recorded and analyzed using SPSS (version 25). Results: Out of 114 patients 81 (71.1%) were males and 33(28.9%) were female with male: female ratio of 2.5:1. Patient’s age ranged from 6- 55 years with mean ± SD age of 26.41 ± 9.7 years. Majority of Patients, 46.5%( 53) were in 2nd decade. Amongst the causes slap outnumbered (80, 70.2%), and left ear was involved predominately (67, 58.7%) affecting mainly anterio-inferior quadrant (50, 43.9%). Small size perforation was most common finding (64, 56.1%). Majority of patients (72, 63.2%) presented in a week time and single perforation was the commonest (107, 93.%). Most of traumatic TM perforation got healed spontaneously (97, 85.1%). Conclusion: It is concluded that spontaneous healing of traumatic membrane perforation occurs in more than 90% cases provided the ear is kept dry and not accompanied by unfavorable conditions. doi: https://doi.org/10.12669/pjms.37.3.3923 How to cite this:Wahid FI, Saleem M, Muhammad R, Khan MR. Aftermath of traumatic tympanic membrane perforation: Our findings at a tertiary care hospital in Pakistan. Pak J Med Sci. 2021;37(3):---------. doi: https://doi.org/10.12669/pjms.37.3.3923 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionsupporting

confidence: 88%

“… 7 The mean age and commonest age of presentation of this study is also comparable with results of Al-Juboori from Iraq and Gao and colleagues from china and some other studies. 8 , 9 …”

Section: Discussionmentioning

confidence: 99%

Aftermath of traumatic tympanic membrane perforation: Our findings at a tertiary care hospital in Pakistan

Wahid¹,

Saleem²,

Muhammad³

et al. 2021

Pak J Med Sci

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“…No higher prevalence of perforations was found in patients under 7 years of age. 19 Results that agree with those published by Brian et al In 2010, where they found an efficiency in the closure of perforations between 70% and 100%, and those of Ryan et al 13 In 2016, with a closure percentage between 35% and 94%, 20 which, although lower than in adults, not negligible in terms of effectiveness. They also do not suggest a strict minimum age to perform this type of surgical procedure, however, some authors propose performing this type of surgical procedure, even in patients aged 4 years.…”

Section: Discussionsupporting

confidence: 84%

“…21,22 In this type of population, the most frequent tympanic perforations are secondary to myringotomy with ventilation tubes, AOM or trauma. 20 Regarding comorbidities, chronic otitis media was related to a higher probability of postoperative reperforation, results similar to those reported by Sajid et al In 2017 12 and by Heo et al 18 In 2017, 23 where it was found that this factor decreases 3.4% the probability of postoperative closure. Likewise, chronic otitis media was also the main cause for which the tympanic membranes were perforated in our study.…”

Section: Discussionsupporting

confidence: 83%

Surgical results of type I tympanoplasty during the years 2014 to 2019, at the hospital universitario clínica San Rafael in Bogotá

DP¹,

C²

2021

JOENTR

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Objective: To determine the frequency of postoperative tympanic reperforations at three months and at six months, in patients who underwent type I tympanoplasty in the otorhinolaryngology service of San Rafael University Clinical Hospital in Bogotá, Colombia, during the years 2014 to 2019. Methodology: retrospective, descriptive and cross-sectional study. Study population and methods: The data were collected from the review of otology outpatient medical records, who met the selection criteria and the surgical criteria for institutional type I tympanoplasty. Results: 47 patients were operated on. 62% were female and 38% male. Postoperative reperforation was evidenced in 8.5% of the total sample. None were before three months, 1 patient between 3 and 6 months postoperative and 3 patients after 6 months postoperative. The most frequent cause for which a patient was led to type I tympanoplasty was infectious, (66%). The otorhinolaryngological comorbidity most frequently associated with perforations was chronic otitis media (COM), in 51%. The audiometries performed showed an improvement of 17% and 20% between the preoperative and postoperative PTA, in the right ear and in the left ear, respectively. Conclusions: The results show that the type of tympanoplasty used in the institution is effective for the anatomical closure of the tympanic perforations included in our study, despite the associated poor prognostic factors, recommending the use of this surgical technique and this type of cartilaginous graft to achieve this main objective.

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“…Hippophae fructus oil (HFO), a traditional Chinese herb extracted from Hippophae fructus, 8‐10 is composed of vitamin C, amino acids, and essential trace elements (e.g., zinc), which can enhance the proliferation of TM epithelial stem cells, promote their migration to lesions and induce blood vessel dilatation 9,10 . During the past few decades, HFO has been applied for the clinical treatment of TM perforation with satisfactory outcomes 8 . However, the biological mechanism of HFO therapy for TM regeneration remains unclear, and the main compounds of HFO that promote TM healing require further exploration.…”

Section: Introductionmentioning

confidence: 99%

The possible mechanism of Hippophae fructus oil applied in tympanic membrane repair identified based on network pharmacology and molecular docking

Huang

Teh

et al. 2021

Clinical Laboratory Analysis

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Objective This study aimed to explore the mechanisms of Hippophae fructus oil (HFO) in the treatment of tympanic membrane (TM) perforation through network pharmacology‐based identification. Methods The compounds and related targets of HFO were extracted from the TCMSP database, and disease information was obtained from the OMIM, GeneCards, PharmGkb, TTD, and DrugBank databases. A Venn diagram was generated to show the common targets of HFO and TM, and GO and KEGG analyses were performed to explore the potential biological processes and signaling pathways. The PPI network and core gene subnetwork were constructed using the STRING database and Cytoscape software. A molecular docking analysis was also conducted to simulate the combination of compounds and gene proteins. Results A total of 33 compounds and their related targets were obtained from the TCMSP database. After screening the 393 TM‐related targets, 21 compounds and 22 gene proteins were selected to establish the network diagram. GO and KEGG enrichment analyses revealed that HFO may promote TM healing by influencing cellular oxidative stress and related signaling pathways. A critical subnetwork was obtained by analyzing the PPI network with nine core genes: CASP3, MMP2, IL1B, TP53, EGFR, CXCL8, ESR1, PTGS2, and IL6. In addition, a molecular docking analysis revealed that quercetin strongly binds the core proteins. Conclusion According to the analysis, HFO can be utilized to repair perforations by influencing cellular oxidative stress. Quercetin is one of the active compounds that potentially plays an important role in TM regeneration by influencing 17 gene proteins.

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Management of traumatic tympanic membrane perforation: a comparative study

Cited by 17 publications

References 19 publications

Aftermath of traumatic tympanic membrane perforation: Our findings at a tertiary care hospital in Pakistan

Aftermath of traumatic tympanic membrane perforation: Our findings at a tertiary care hospital in Pakistan

Surgical results of type I tympanoplasty during the years 2014 to 2019, at the hospital universitario clínica San Rafael in Bogotá

The possible mechanism of Hippophae fructus oil applied in tympanic membrane repair identified based on network pharmacology and molecular docking

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