2021
DOI: 10.1002/jcla.24157
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The possible mechanism of Hippophae fructus oil applied in tympanic membrane repair identified based on network pharmacology and molecular docking

Abstract: Objective This study aimed to explore the mechanisms of Hippophae fructus oil (HFO) in the treatment of tympanic membrane (TM) perforation through network pharmacology‐based identification. Methods The compounds and related targets of HFO were extracted from the TCMSP database, and disease information was obtained from the OMIM, GeneCards, PharmGkb, TTD, and DrugBank databases. A Venn diagram was generated to show the common targets of HFO and TM, and GO and KEGG analyses were performed to explore the potentia… Show more

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Cited by 6 publications
(1 citation statement)
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“…However, there is currently no research on Fructus hippophae genomic information. Studies on Fructus hippophae are currently limited to compounds and their related protein targets of Hippophae Fructus oil (HFO), relying on the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP: https://old.tcmsp-e.com/tcmsp.php ) 22 . Other studies have focused on methods of extracting and purifying flavonoids, tannins, and other novel nutritional supplements from Fructus hippophae , which depend on spectrophotometry, chromatography and other chemical methods 23 – 25 .…”
Section: Background and Summarymentioning
confidence: 99%
“…However, there is currently no research on Fructus hippophae genomic information. Studies on Fructus hippophae are currently limited to compounds and their related protein targets of Hippophae Fructus oil (HFO), relying on the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP: https://old.tcmsp-e.com/tcmsp.php ) 22 . Other studies have focused on methods of extracting and purifying flavonoids, tannins, and other novel nutritional supplements from Fructus hippophae , which depend on spectrophotometry, chromatography and other chemical methods 23 – 25 .…”
Section: Background and Summarymentioning
confidence: 99%