Comparative study on the main active components of Baoyuan decoction in plasma and urine of normal and heart failure rats

Abstract

The global morbidity and mortality of heart failure has been increasing in recent years. Traditional Chinese medicine (TCM) was increasingly used to treat cardiovascular diseases. Baoyuan decoction (BYD) was a famous classical prescription in China. Modern pharmacological studies showed that it had obvious therapeutic effects on cardiovascular diseases, but its pathological pharmacokinetic studies were unclear. In this research, the absorption of 16 bioactive components in plasma and the excretion of 9 representative components in urine of control rats and isoproterenol (ISO)‐induced heart failure rats were studied using the large‐volume direct‐injection LC–MS method established by our research group. The results indicated that flavonoid constituents exhibited quicker absorption and elimination than saponin constituents after oral administration of BYD. The half‐life period of some bioactive compounds in the model group was increased, which contributed to the longer therapeutic effect. The cumulative excretion rate of major flavonoid components of BYD decreased significantly in the ISO‐induced heart failure rats.

Integrated analysis of phytochemical composition, pharmacokinetics, and network pharmacology to probe distinctions between the stems ofCistanche deserticolaandC. tubulosabased on antidepressant activity

“…In addition, metabolism enzymes, transport proteins, cell membrane permeability, and gut microbiota are easily altered under pathological states, thereby affecting the absorption, distribution, metabolism, and excretion of the medical supplements and influencing their efficacy. 18–20 Interestingly, we found that the pharmacokinetic behaviors of the above compounds in the CUMS rats differed from those in normal rats after CDE and CTE administration. The relative bioavailability of the most absorbed compounds of CH under a depression-like state was generally higher, which are related with the pathological conditions in depressed rats, such as enhanced intestinal epithelial permeability, 21 gut microbiota dysfunction, 22 and CYP450 activity alternation, 23 but the specific mechanism remains to be further explored.…”