2020
DOI: 10.1002/term.3093
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Comparative technical analysis of lipoaspirate mechanical processing devices

Abstract: Fat grafting is a well‐established procedure in reconstructive, aesthetic, and regenerative medicine, in particular due to the presence in the adipose tissue of a high concentration of mesenchymal stem cells. The need to reduce fat processing times, for an immediate clinical use and regulatory restrictions on the degree of manipulation of human tissues, has led to the development of numerous devices for the mechanical, nonenzymatic processing of adipose tissue. The aim of this study is to describe the state of… Show more

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Cited by 5 publications
(3 citation statements)
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“…Other publications have reported clinical outcome data alone from using these POC devices/systems (Table 5), but only Lipogems [7, 21, 36, 47, 57–59, 72, 73, 76], MyStem EVO [55] and Hy‐Tissue SVF [71] been used in orthopaedic related studies. Lipogems is a closed system which performs washing, filtration and sedimentation, with manual shaking and emulsification also required [74]. It has become popular in orthopaedics, having established an early patent for clinical use [68], as well as being a user‐friendly system [68].…”
Section: Discussionmentioning
confidence: 99%
“…Other publications have reported clinical outcome data alone from using these POC devices/systems (Table 5), but only Lipogems [7, 21, 36, 47, 57–59, 72, 73, 76], MyStem EVO [55] and Hy‐Tissue SVF [71] been used in orthopaedic related studies. Lipogems is a closed system which performs washing, filtration and sedimentation, with manual shaking and emulsification also required [74]. It has become popular in orthopaedics, having established an early patent for clinical use [68], as well as being a user‐friendly system [68].…”
Section: Discussionmentioning
confidence: 99%
“…These methods utilize physical forces to gently break down the extracellular matrix and isolate stem cell-rich products through various techniques, including centrifugation, filtration, decantation, emulsification, sedimentation, squeezing, or washing. 55,56 While this can be done manually, mechanical devices developed for intraoperative use provide a more controlled approach, reducing time constraints and potential contamination risks. [57][58][59][60][61] Devices differ based on their specific features, the combination of isolation techniques used, and the degree of tissue dissociation and final product.…”
Section: Isolation Methodsmentioning
confidence: 99%
“…Fat grafting is a consolidated procedure in reconstructive, aesthetic, and regenerative medicine due to the presence in the adipose tissue of a high concentration of MSCs [ 68 , 69 ]. The regenerative potential of adipose tissue is well known, and it is continuously updated thanks to numerous studies concerning the application of autologous adipose tissue transplantation in reconstructive and regenerative medicine [ 70 , 71 , 72 ].…”
Section: Fat As An Optimal Source Of Muse Cells Isolationmentioning
confidence: 99%