Comparative tissue uptake and cellular deposition of three different plutonium chemical forms in rats

Fouillit, M.; Grillon, G.; Fritsch, P.; Rateau, G.; Pavé, D; Delforge, Jacques; Gall, B. Le

doi:10.1080/09553000400005486

Cited by 30 publications

(14 citation statements)

References 17 publications

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“…Most studies on lanthanides were conducted before the 1970's; at that time our ability to detect subcellular distribution and biotransformations of these elements was much less than today. However, even a few of the more modern examples of these studies (e.g., uptake of Pu of different oxidation states in mice [Fouillit et al, 2004] and in the cells in culture [Planasbohne and Duffield, 1988]) give no detailed account of the exact intracellular localization and speciation.…”

Section: Discovery Of Accidental or Otherwise Unintentional Introductmentioning

confidence: 99%

X‐ray fluorescence microprobe imaging in biology and medicine

Paunesku

Vogt

Mäser

et al. 2006

J of Cellular Biochemistry

224

164

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Characteristic X-ray fluorescence is a technique that can be used to establish elemental concentrations for a large number of different chemical elements simultaneously in different locations in cell and tissue samples. Exposing the samples to an X-ray beam is the basis of X-ray fluorescence microscopy (XFM). This technique provides the excellent trace element sensitivity; and, due to the large penetration depth of hard X-rays, an opportunity to image whole cells and quantify elements on a per cell basis. Moreover, because specimens prepared for XFM do not require sectioning, they can be investigated close to their natural, hydrated state with cryogenic approaches. Until several years ago, XFM was not widely available to bio-medical communities, and rarely offered resolution better then several microns. This has changed drastically with the development of third-generation synchrotrons. Recent examples of elemental imaging of cells and tissues show the maturation of XFM imaging technique into an elegant and informative way to gain insight into cellular processes. Future developments of XFM-building of new XFM facilities with higher resolution, higher sensitivity or higher throughput will further advance studies of native elemental makeup of cells and provide the biological community including the budding area of bionanotechnology with a tool perfectly suited to monitor the distribution of metals including nanovectors and measure the results of interactions between the nanovectors and living cells and tissues. Key words: X-ray fluorescence microscopy; elemental maps; metalome; bionanotechnology The biology of the past decade has significantly changed scope, and large compendia of data have been accumulated to enable scientists to study biological ''meta units'' such as the genome, proteome, and transcriptome. At this time, the term ''metalome'' is still used only rarely, and the majority of scientists interested in establishing metalome databases undertook the daunting task of developing and using different dyes for different elements and their ions in order to determine elemental locations and concentrations in cells and tissues. The presence of metals and trace elements is essential for the existence of life as we know it. In any organism, there are very few intracellular processes that are not dependent on the presence of metals or other trace elements. In fact, it is estimated that one-third of all known proteins contain metal cofactors and the majority of these function as essential metalloenzymes. With current developments in genomics and proteomics, our knowledge of the enormous number of pathways in which metals and trace elements are necessary for life is ever increasing. This knowledge, however, is largely ''static'' as we still do not have appropriate sensitive approaches to follow fluctuations in normal metal homeostasis that accompany processes of development, differentiation, senescence, stress responses, etc. Likewise, our knowledge about the redistribution of metals and trace elements accom...

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Section: Discovery Of Accidental or Otherwise Unintentional Introductmentioning

confidence: 99%

X‐ray fluorescence microprobe imaging in biology and medicine

Paunesku

Vogt

Mäser

et al. 2006

J of Cellular Biochemistry

224

164

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“…Several reviews [13,14,19,20] present the possible transfer mechanisms of Np(V), Pu(IV) and Am(III) from blood to liver cells, and describe possible time-and mass-dependent binding of these actinides in the liver cells with high molecular weight proteins such as calmodulin, ferritin and lipofuscin. It has also been shown [21] that hepatocyte cells concentrate more plutonium than sinusoidal cells and that Kuppfer cells play an important role in the phagocytosis of polymeric forms of plutonium.…”

Section: Main Actinides' Biological Ligandsmentioning

confidence: 99%

Review of actinide decorporation with chelating agents

Ansoborlo

Amekraz

Moulin

et al. 2007

Comptes Rendus. Chimie

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In case of accidental release of radionuclides in a nuclear facility or in the environment, internal contamination (inhalation, ingestion or wound) with actinides represents a severe health risk to human beings. It is therefore important to provide effective chelation therapy or decorporation to reduce acute radiation damage, chemical toxicity, and late radiation effects.Speciation governs bioavailability and toxicity of elements and it is a prerequisite tool for the design and success of new ligands or chelating agents. The purpose of this review is to present the state-of-the-art of actinide decorporation within biological media, to recall briefly actinide metabolism, to list the basic constraints of actinideeligand for development, to describe main tools developed and used for decorporation studies, to review mainly the chelating agents tested for actinides, and finally to conclude on the future trends in this field. To cite this article: É. Ansoborlo et al., C. R. Chimie X 33 (2007). Ó 2007 Académie des sciences. Published by Elsevier Masson SAS. All rights reserved. RésuméEn cas de rejet accidentel de radionucléides dans une installation nucléaire ou dans l'environnement, il existe un risque de contamination interne (inhalation, ingestion ou blessure) pour l'homme et il est important de pouvoir fournir un traitement thérapeutique par des agents chélatants ou décorporation permettant de réduire la dose, la toxicité chimique et les effets retardés des radiations.La spéciation domine la biodisponibilité et la toxicité des éléments et représente un outil indispensable pour la conception et l'efficacité de nouveaux ligands ou chélatants. Le but de cet article est de présenter l'état de l'art sur la décorporation des actinides en milieu biologique, de rappeler les grandes lignes du métabolisme des actinides, de lister les contraintes indispensables actinidee

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“…Most actinide studies were carried out with actinides in higher oxidation states, especially with uranium(VI) (Carrière et al, 2004(Carrière et al, , 2005aMilgram et al, 2008aMilgram et al, , 2007Milgram et al, , 2008bMirto et al, 1999a,b;Muller et al, 2006;Rouas et al, 2010), for which the relationship between its speciation and its cytotoxicity onto mammalian cells is comprehensively studied. A second, well studied actinide is plutonium(IV), whose uptake and binding was studied with various cell lines Fouillit et al, 2004;Gorman-Lewis et al, 2011;Jensen et al, 2012Jensen et al, , 2011Planas-Bohne and Duffield, 1988;Planas-Bohne et al, 1985Planas-Bohne and Rau, 1990;Schuler and Taylor, 1987). For trivalent actinides, the chemical analogs of lanthanides, no studies concerning their biological interactions are reported up to date.…”

Section: Introductionmentioning

confidence: 99%