Comparative toxic responses of male and female lizards (Eremias argus) exposed to (S)-metolachlor-contaminated soil

Chen, Li; Wang, Dezhen; Tian, Zhongnan; Di, Shanshan; Zhang, Wenjun; Wang, Fang; Zhou, Zhiqiang; Diao, Jinling

doi:10.1016/j.envpol.2017.05.006

Cited by 6 publications

(4 citation statements)

References 41 publications

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“…Female E. argus was predicted to be more sensitive than males to pesticide dermal exposure regarding liver lesions . Therefore, 2–3 year-old sexually mature female E.…”

Section: Methodsmentioning

confidence: 99%

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Temperature-Dependent Bioaccumulation, Metabolism, and Hepatotoxicity of Flufiprole in Lizards (Eremias argus)

Chang,

An,

Xie

et al. 2023

Environ. Sci. Technol.

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As a phenylpyrazole insecticide, flufiprole is an important substitute for fipronil in the agricultural field of China. However, its bioaccumulation and metabolism in terrestrial organisms especially in the lizards living in the agricultural area have rarely been investigated. As an ectothermic animal, lizards are also sensitive to temperature changes. Considering global warming, this study measured bioaccumulation, metabolism, and hepatotoxicity of flufiprole in the Chinese native lizard (Eremias argus) under different temperature stresses. Lizards exposed to flufiprole-contaminated soil adsorbed flufiprole through the skin and flufiprole was preferred to accumulate in lizard liver and brain. The oxidation product fipronil sulfone was the main metabolite of flufiprole in both lizard liver and human liver microsomes, which were mainly metabolized by lizard CYP3A19 or human CYP3A4. The fipronil sulfone concentration increased with increased temperature in lizard tissues. In addition, more serious oxidative damage was shown under higher temperature as the glutathione (GSH), malondialdehyde (MDA), and 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels in lizards increased with increased temperature after flufiprole exposure. Flufiprole exposure also induced lizard liver lesions, and these lesions became more serious in the higher-temperature groups. This study provided new insights into the risk assessment of flufiprole in lizards under global warming.

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“…Female E. argus was predicted to be more sensitive than males to pesticide dermal exposure regarding liver lesions . Therefore, 2–3 year-old sexually mature female E.…”

Section: Methodsmentioning

confidence: 99%

“…17 Female E. argus was predicted to be more sensitive than males to pesticide dermal exposure regarding liver lesions. 20 Therefore, 2−3 yearold sexually mature female E. argus was used in this study. Test lizards were collected from our breeding colony in the Changping district, Beijing, China.…”

Section: Test Lizards Selection and Exposure Experimentmentioning

confidence: 99%

Temperature-Dependent Bioaccumulation, Metabolism, and Hepatotoxicity of Flufiprole in Lizards (Eremias argus)

Chang,

An,

Xie

et al. 2023

Environ. Sci. Technol.

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“…Metolachlor (2-chloro-N-(2-ethyl-6-methylphenyl)-N-(2-metoxy-1-methylethyl) acetamide, Figure 2) on the other hand is a discriminatory herbicide from chloroacetamide group which hinder seed germination by inhibiting mitosis and cell division [14], as well as preventing the synthesis of chlorophyll, fatty acids, lipids and proteins [15]. Like atrazine, http://eaht.org metolachlor has also been found to linger on agricultural soil, in surface waters as well as groundwater [16][17][18].…”

Section: Introductionmentioning

confidence: 99%

“…Like atrazine, http://eaht.org metolachlor has also been found to linger on agricultural soil, in surface waters as well as groundwater [16][17][18]. Studies have also shown that metolachlor could adversely affect the functions of the male reproductive system by various mechanisms including modulation of testosterone production via increase in the activity of aromatase enzyme in a human cell line, as well as via other mechanisms [15,[17][18][19]. As stated above, ATR-MET is ATR in combination with MET, however, little is known about the toxicity of this formulation.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the toxicological effects of atrazine-metolachlor in male rats: in vivo and in silico studies

Olayinka

Ore

Adewole

et al. 2022

Environ Anal Health Toxicol

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The types and mechanisms of atrazine-metolachlor toxicity, an herbicide composed of atrazine (ATR) and metolachlor (MET), need to be further investigated. This study evaluated the toxic actions of ATR-MET by in vivo and in silico methods. Here, varying doses of ATR-MET were orally administered to rats once daily for twenty-one days using normal saline as control. Molecular docking was used to characterize the binding of ATR and MET with androgen receptor (AR) to predict their potential endocrine-disrupting effects, using testosterone as benchmark. ATR-MET-induced-testicular toxicity (reduced sperm motility, count, and daily sperm production and increased live/dead ratio) was accompanied with testicular oxidative stress (diminished level of reduced glutathione, activities of glutathione-S-transferase, superoxide dismutase and catalase and increased level of malondialdehyde). Furthermore, ATR-MET induced cardiovascular toxicity (increased levels of plasma total cholesterol, HDL-cholesterol, LDL-cholesterol, and triglycerides) with concomitant induction of renal toxicity (increased plasma creatinine and urea levels), and hepatotoxicity (increased plasma bilirubin, alkaline phosphatase, acid phosphatase, alanine aminotransferase and aspartate aminotransferase). Binding energy and amino acid interactions from in silico study revealed that MET possessed endocrine-disrupting capacity. In conclusion, exposure to atrazine-metolachlor could promote cardiovascular, renal, hepatic, as well as reproductive impairment in experimental male albino rats.

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Stereoselective metabolism and potential adverse effects of chiral fungicide triadimenol on Eremias argus

Wang

Tian

Chen

et al. 2019

Environ Sci Pollut Res

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Comparative toxic responses of male and female lizards (Eremias argus) exposed to (S)-metolachlor-contaminated soil

Cited by 6 publications

References 41 publications

Temperature-Dependent Bioaccumulation, Metabolism, and Hepatotoxicity of Flufiprole in Lizards (Eremias argus)

Temperature-Dependent Bioaccumulation, Metabolism, and Hepatotoxicity of Flufiprole in Lizards (Eremias argus)

Evaluation of the toxicological effects of atrazine-metolachlor in male rats: in vivo and in silico studies

Stereoselective metabolism and potential adverse effects of chiral fungicide triadimenol on Eremias argus

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