Comparative toxicity of Chlorothalonil: Ceriodaphnia dubia and Pimephales promelas

Sherrard, Rick M.; Murray-Gulde, Cynthia L.; Rodgers, John H.; Shah, Yatish T.

doi:10.1016/s0147-6513(02)00073-8

Cited by 38 publications

(26 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, based on the environmental fate properties of chlorothalonil, exposures are likely to be acute (short-term), so survival/mortality is another potential endpoint of concern. Both fecundity and survival endpoints were addressed in the present study, with no significant effects on either, even though the maximum exposure concentration was 15.5 µg/L, from a wileyonlinelibrary.com/ETC © 2019 The Authors pulsed exposure that averaged 14.1 µg/L over 20 h. This compares to a reported 48-h LC50 for chlorothalonil to fathead minnow of 22.9 µg/L (Sherrard et al 2003) and a LOEC from a fathead minnow fish full-life cycle study of 3 µg/L, based on fecundity (European Commission 2016). What is clear is that, in the present study, all pulsed concentrations tested were far in excess of the fish chronic RAC of 0.14 µg/L used in the initial risk assessment in European Union (fish full-life cycle NOEC of 1.4 μg/L divided by an assessment factor of 10) and produced no significant adverse effects on fish fecundity.…”

Section: Discussionmentioning

confidence: 50%

A Pulsed‐Dose Study Evaluating Chronic Toxicity of Chlorothalonil to Fish: A Case Study for Environmental Risk Assessment

Hamer

Maynard

Schneider³

2019

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

Chlorothalonil is a fungicide which is highly toxic to aquatic organisms. However, in natural aquatic environments, it is very rapidly degraded, with a half‐life typically in hours, reducing exposure of aquatic organisms and the potential for effects. In standard regulatory studies looking at the chronic toxicity of chlorothalonil to fathead minnow, the most sensitive endpoint was fecundity. A standard fish full–life cycle study, where chlorothalonil concentrations were maintained constant throughout, resulted in a no‐observed‐effect concentration (NOEC) of 1.4 µg/L. Comparing peak modeled exposure concentrations to this NOEC can result in the chronic risk to fish being considered unacceptable. The present study investigated the effect on fecundity in fathead minnow using a fish short‐term reproduction assay. Five different exposure profiles were employed with time‐varying concentrations based on realistic worst‐case modeled environmental exposure profiles, multiplied by an assessment factor of 10, which resulted in maximum measured concentrations up to 15.5 µg/L. There were no effects on fecundity from any of the exposure profiles tested. Therefore, based on these more realistic exposure profiles, the chronic risk to fish could be considered acceptable if these exposures were deemed to be representative of the worst case. Environ Toxicol Chem 2019;38:1549–1559. © 2019 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals, Inc. on behalf of SETAC.

show abstract

Section: Discussionmentioning

confidence: 50%

A Pulsed‐Dose Study Evaluating Chronic Toxicity of Chlorothalonil to Fish: A Case Study for Environmental Risk Assessment

Hamer

Maynard

Schneider³

2019

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

show abstract

“…Toxicity to adults was intermediate with a LC 50 = 152.9 μg L -1 (Key et al, 2003). Sherrard et al (2003) reported LC 0 , lowest observable eff ects concentration, LC 50 , and LC 100 values for 7-d exposure of Pimephales promelas of 14.4, 15, 22.6, and 30.8 μg L -1 , respec-tively. Th e same values for Ceriodaphnia dubia were 103, 125, 156, and 210 μg L -1 , respectively (Sherrard et al, 2003).…”

Section: Chlorothalonil Eventmentioning

confidence: 93%

Nontarget Deposition and Losses of Chlorothalonil in Irrigation Runoff Water from a Commercial Foliage Plant Nursery

Riiska

Albano

2010

J of Env Quality

View full text Add to dashboard Cite

Commercial foliage plant production requires the use of pesticides for controlling pests and pathogens that can reduce aesthetic qualities of crops, rendering them unwanted by consumers. Chlorothalonil is a common, broad-spectrum, foliar fungicide used for protecting plants from a variety of fungal diseases. This fungicide may also be acutely toxic to nontarget aquatic organisms due to its mode of action. This study evaluated the amount of chlorothalonil deposited on nontarget ground surfaces during normal sprayer applications at a commercial nursery using Teflon targets. One day following application, irrigation runoff events were initiated and runoff water samples were collected and analyzed for chlorothalonil. Discharge volumes were also measured to allow estimation of the total mass of chlorothalonil discharged during each event. Results indicated that 9.8 to 53.6% of the active ingredient applied landed on nontarget ground surfaces depending on plant size, spacing, and row lengths (short rows sprayed from one side vs. longer rows sprayed from both ends). On an entire production-area scale, 29.2% of the active ingredient applied was deposited on ground surfaces. Of the total nontarget deposition, 0.25 to 0.53% was detected in runoff water discharged from the production area. Concentrations ranged from 1.2 to 500 microg/L during the first runoff events following application.

show abstract

“…The fungicidal activity exhibited by chlorothalonil is attributed to the inactivation of cell sulfhydryl enzymes (Vincent and Sisler 1968;Sherrard et al 2003). Gallagher et al (1992) recorded a depletion of glutathione, resulting in the inhibition of glucose oxidation in exposed channel catfish.…”

Section: Mode Of Actionmentioning

confidence: 99%

Environmental Fate and Toxicology of Chlorothalonil

Scoy

Tjeerdema

2014

Reviews of Environmental Contamination and Toxicology

View full text Add to dashboard Cite

Comparative toxicity of Chlorothalonil: Ceriodaphnia dubia and Pimephales promelas

Cited by 38 publications

References 9 publications

A Pulsed‐Dose Study Evaluating Chronic Toxicity of Chlorothalonil to Fish: A Case Study for Environmental Risk Assessment

A Pulsed‐Dose Study Evaluating Chronic Toxicity of Chlorothalonil to Fish: A Case Study for Environmental Risk Assessment

Nontarget Deposition and Losses of Chlorothalonil in Irrigation Runoff Water from a Commercial Foliage Plant Nursery

Environmental Fate and Toxicology of Chlorothalonil

Contact Info

Product

Resources

About