Comparative Toxicity of Endosulfan and Fipronil Insecticides: Utilizing In Vivo and In Vitro Data

Silva, Marilyn H.; Koshlukova, Svetlana E.

doi:10.21767/2471-9641.10009

Cited by 2 publications

(3 citation statements)

References 11 publications

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“…Endosulfan is a lipophilic pesticide compound that is stable in the environment and that blocks phagocytic metabolic activity in the peripheral blood [40,41]. This indicates that, even at low concentrations, endosulfan exposure can harm the immune system in the long term.…”

Section: Endosulfan Association To Increased Serum Levels Of Il-1β Il-6 Il-17 and Tnf-αmentioning

confidence: 99%

Endosulfan Increases IL-1β, IL-6, IL-17, and TNF-α Production in Pregnant Rats and Causes Fetal Brain Cell Apoptosis

Andarini

Madjri

Sujuti

et al. 2019

Walailak J Sci & Tech

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Endosulfan is a persistent organic pollutant commonly used as an insecticide in Indonesia. It has been reported to cause teratogenic effects, i.e., to decrease humoral activity, produce inflammation, and induce apoptosis in various type of cells. This study investigated the effect of endosulfan on the expression of IL-1β, IL-6, IL-17, and TNF-α in rats (Rattus norvegicus), as well as the incidence of fetal brain cell apoptosis. This experiment was carried out on pregnant rats divided into 4 groups: negative control (I), endosulfan: 1 mg/kg (II), 10 mg/kg (III), and 50 mg/kg (IV). The solution of endosulfan was given daily during the 20-day test period. Rat serum was collected for the measurement of IL-1β, IL-6, IL-17, and TNF-α using the ELISA kit. Fetal rat brains were taken and stained with Annexin V for apoptosis detection. The proinflammatory cytokine levels in Groups II, III, and IV were higher than in Group I, with significant increases of IL-1β (p = 0.016), IL-6 (p = 0.009), IL-17 (p < 0.001), and TNF-α (p < 0.001). The intensity of Annexin V in 4 groups of rats showed that the incidence of apoptosis increased with increasing endosulfan doses. In conclusion, the administration of endosulfan in pregnant rats increased the expression of IL-1β, IL-6, IL-17, and TNF-α and triggered apoptosis in fetal brain cells.

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Section: Endosulfan Association To Increased Serum Levels Of Il-1β Il-6 Il-17 and Tnf-αmentioning

confidence: 99%

Endosulfan Increases IL-1β, IL-6, IL-17, and TNF-α Production in Pregnant Rats and Causes Fetal Brain Cell Apoptosis

Andarini

Madjri

Sujuti

et al. 2019

Walailak J Sci & Tech

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“…Fipronil is an organic insecticide of the phenylpyrazole family, discovered and developed by Rhône-Poulenc between 1985 and 1987 [ 1 ] and marketed since 1993 [ 1 ]. Its increasing widespread use has raised concerns about the possible effects on the integrity of humans and animals [ 1 , 2 , 3 , 4 ]. Fipronil can have a half-life ranging from 15 to 105 days, depending on the soil type and the application of residues such as vinasse and filter cake.…”

Section: Introductionmentioning

confidence: 99%

“…Another study reported half-lives of fipronil in clay loam soils containing 0.50 mg/kg of the pesticide, which varied from about 4 to 6 days, while the value in the soil (control) was about 100 days [ 15 ]. The possible impacts of the use of fipronil on the environment and non-target species [ 3 , 4 , 5 , 15 ] and its persistence in soil [ 5 , 15 ] are attracting increasing attention in research and in the search for microorganisms that have the potential to biodegrade this compound, as the use of fipronil is of great interest to the environment. For this reason, knowledge of the microbial community in the soil can provide information that favors the search for microorganisms with biotechnological potential, since this ecosystem can be considered the habitat with the greatest bacterial diversity [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

New Insights into the Effect of Fipronil on the Soil Bacterial Community

et al. 2022

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Fipronil is a broad-spectrum insecticide with remarkable efficacy that is widely used to control insect pests around the world. However, its extensive use has led to increasing soil and water contamination. This fact is of concern and makes it necessary to evaluate the risk of undesirable effects on non-target microorganisms, such as the microbial community in water and/or soil. Studies using the metagenomic approach to assess the effects of fipronil on soil microbial communities are scarce. In this context, the present study was conducted to identify microorganisms that can biodegrade fipronil and that could be of great environmental interest. For this purpose, the targeted metabarcoding approach was performed in soil microcosms under two environmental conditions: fipronil exposure and control (without fipronil). After a 35-day soil microcosm period, the 16S ribosomal RNA (rRNA) gene of all samples was sequenced using the ion torrent personal genome machine (PGM) platform. Our study showed the presence of Proteobacteria, Actinobacteria, and Firmicutes in all of the samples; however, the presence of fipronil in the soil samples resulted in a significant increase in the concentration of bacteria from these phyla. The statistical results indicate that some bacterial genera benefited from soil exposure to fipronil, as in the case of bacteria from the genus Thalassobacillus, while others were affected, as in the case of bacteria from the genus Streptomyces. Overall, the results of this study provide a potential contribution of fipronil-degrading bacteria.

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Comparative Toxicity of Endosulfan and Fipronil Insecticides: Utilizing In Vivo and In Vitro Data

Cited by 2 publications

References 11 publications

Endosulfan Increases IL-1β, IL-6, IL-17, and TNF-α Production in Pregnant Rats and Causes Fetal Brain Cell Apoptosis

Endosulfan Increases IL-1β, IL-6, IL-17, and TNF-α Production in Pregnant Rats and Causes Fetal Brain Cell Apoptosis

New Insights into the Effect of Fipronil on the Soil Bacterial Community

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