1994
DOI: 10.1007/bf01746062
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Comparative toxicity of oxidatively modified low-density lipoprotein and lysophosphatidylcholine in cultured vascular endothelial cells

Abstract: Oxidative modification of low-density lipoprotein (LDL) may play an important role in the initiation and progression of atherosclerosis. We previously showed that the cytotoxicity of oxidized LDL (oxLDL) depended on the level of lipid hydroperoxides. Meanwhile, it has been shown that during LDL oxidation, a significant part of the LDL phosphatidylcholine (PC) is degraded to lysophosphatidylcholine (LPC) by an intrinsic phospholipase A2-like activity, and that LPC is toxic to various cells. In the present study… Show more

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Cited by 11 publications
(1 citation statement)
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“…In a control experiment, pertussis toxin did not inhibit FGF-2-induced DNA synthesis (data not shown). Both lysoPC and lysoPA have similar binding affinities to albumin (35), and bovine serum albumin has been shown to decrease the cytotoxicity of lysoPC in vascular endothelial cells (21). In our vascular SMC system, albumin inhibited the DNA synthesis induced by lysoPC but not that induced by lysoPA (data not shown).…”
Section: Resultsmentioning
confidence: 60%
“…In a control experiment, pertussis toxin did not inhibit FGF-2-induced DNA synthesis (data not shown). Both lysoPC and lysoPA have similar binding affinities to albumin (35), and bovine serum albumin has been shown to decrease the cytotoxicity of lysoPC in vascular endothelial cells (21). In our vascular SMC system, albumin inhibited the DNA synthesis induced by lysoPC but not that induced by lysoPA (data not shown).…”
Section: Resultsmentioning
confidence: 60%