Comparative toxicological study of ethylglycol acetate and butylglycol acetate

Hematological Follow‐up of an Intervention Program Adding Rubber Glove‐Wearing to Local Ventilation for 2‐Ethoxyethanol Acetate‐Exposed Workers

“…Johnson in his final report on the safety assessment of 2-EE and 2-EEA stated that mild anemia has been reported in individuals exposed occupationally to 2-EE, which resolved when the chemical was no longer used 25) . Several animal studies have also reported hematological toxicity induced by 2-EEA and 2-EE [26][27][28] . As far as we could determine, there are no reports on recovery from the hematological effects of 2-EE or 2-EEA in humans.…”

Scientific Opinion on Flavouring Group Evaluation 9, Revision 3 (FGE.09Rev3): Secondary alicyclic saturated and unsaturated alcohols, ketones and esters containing secondary alicyclic alcohols from chemical group 8 and 30, and an ester of a phenol derivative from chemical group 25

“…When the candidate substance 3,3,5-trimethylcyclohexan-1-one , was given to rats and rabbits glucuronides of 3,5,5-trimethyl cyclohexanol were detected in the urine (Truhaut et al, 1979).…”

Ethylene glycol monoethyl ether [MAK Value Documentation, 2008]

“…Changes in the blood count and in the testes were observed in rabbits at 400 ml/m 3 ; the NOAEC for EGEE is 100 ml/m 3 (Barbee et al 1984; Table 2). Inhalation studies carried out with EGEE acetate in rats and rabbits for 10 months revealed nephritis in male rats and slight kidney changes in rabbits at the only tested concentration of 200 ml/m 3 (Truhaut et al 1979;Table 3). No effects were observed in an inhalation study with up to 24-week exposure carried out in dogs at the only investigated concentration of 600 ml/m 3 (ECB 2000 b; Table 3).…”