Comparative transcriptional profiling of human Merkel cells and Merkel cell carcinoma

Mouchet, Nicolas; Coquart, N.; Lebonvallet, Nicolas; Mogha, Ariane; Fautrel, Alain; Boulais, Nicholas; Dréno, Brigitte; Martin, Ludovic; Hu, Weiguo; Galibert, Marie‐Dominique; Miséry, Laurent

doi:10.1111/exd.12546

Cited by 5 publications

(5 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, it is important to mention that the origin of MCC is controversial, and it is yet unclear whether MCC originates from Merkel cells. [214][215][216][217][218][219] Supporting this notion, recent studies have identified a role for LSD1 in human MCC cell proliferation and survival. LSD1 is a lysine-specific histone demethylase that removes mono-and di-methylation from histone H3K4, which are associated with active transcription.…”

Section: Oss-ronen and Cohenmentioning

confidence: 85%

Epigenetic regulation and signalling pathways in Merkel cell development

Oss-Ronen

Cohen

2021

Experimental Dermatology

View full text Add to dashboard Cite

Merkel cells are specialized epithelial cells connected to afferent nerve endings responsible for light-touch sensations, formed at specific locations in touch-sensitive regions of the mammalian skin. Although Merkel cells are descendants of the epidermal lineage, little is known about the mechanisms responsible for the development of these unique mechanosensory cells. Recent studies have highlighted that the Polycomb group (PcG) of proteins play a significant role in spatiotemporal regulation of Merkel cell formation. In addition, several of the major signalling pathways involved in skin development have been shown to regulate Merkel cell development as well. Here, we summarize the current understandings of the role of developmental regulators in Merkel cell formation, including the interplay between the epigenetic machinery and key signalling pathways, and the lineage-specific transcription factors involved in the regulation of Merkel cell development.

show abstract

Section: Oss-ronen and Cohenmentioning

confidence: 85%

Epigenetic regulation and signalling pathways in Merkel cell development

Oss-Ronen

Cohen

2021

Experimental Dermatology

View full text Add to dashboard Cite

show abstract

“…One of the few distinguishing factors between MCPyV-negative and MCPyV-positive MCC was the increased expression of cell adhesion molecules seen in MCPyV-negative MCC. 124 No definitive conclusions could be drawn; however, the study identifies a number of genes and pathways that can be further evaluated in the search for novel treatment strategies. Both antiviral and immune-modulating therapeutic options are being explored.…”

Section: Potential Therapiesmentioning

confidence: 99%

Merkel cell carcinoma of the head and neck: pathogenesis, current and emerging treatment options

Saini

Miles

2015

OTT

View full text Add to dashboard Cite

Merkel cell carcinoma (MCC) is a relatively uncommon, neuroendocrine, cutaneous malignancy that often exhibits clinically aggressive features and is associated with a poor prognosis. It typically presents as a painless, rapidly enlarging, dome-shaped red or purplish nodule in a sun-exposed area of the head and neck or upper extremities. Our understanding of MCC has increased dramatically over the last several years and the pathogenesis continues to be an area of active research. The etiology is likely multifactorial with immunosuppression, UV-induced skin damage, and viral factors contributing to the development of MCC. The recent discovery of Merkel cell polyomavirus has allowed for at least one aspect of disease development to be much better understood. In most cases, treatment consists of wide local excision with adjuvant radiation therapy. The role of chemotherapeutics is still being defined. The recent advancement of knowledge regarding the pathogenesis of MCC has led to an explosion research into novel therapeutic agents and strategies. This review seeks to summarize the current body of literature regarding the pathogenesis of MCC and potential targets for future therapies.

show abstract

“…The recent discovery of MCPyV and the knowledge of molecular pathways involved in the development of MCC has led to significant research into new therapeutic options. 98 DNA mutations in MCC-related genes have recently been discovered (PDE4DIP, MLL3, ERCC5, AURKB, ATR, TSHR, and BCL2L2), however, further investigation for potential therapeutic targets is required. 42 Both antiviral and immune modulating therapeutic options are being explored and the potential for MCPyV vaccination is currently being examined in the mouse model.…”

Section: Potential Future Therapiesmentioning

confidence: 99%

“…Although the current NCCN guidelines do not comment on potential future therapies for obvious reasons, a brief review of the therapeutic horizon for MCC is warranted. The recent discovery of MCPyV and the knowledge of molecular pathways involved in the development of MCC has led to significant research into new therapeutic options . DNA mutations in MCC‐related genes have recently been discovered (PDE4DIP, MLL3, ERCC5, AURKB, ATR, TSHR, and BCL2L2), however, further investigation for potential therapeutic targets is required .…”

Section: Introductionmentioning

confidence: 99%