No abstract

This epidemiological study on sarcoidosis in Guadeloupe reveals a low incidence of the disease and a high degree of severity as evidenced by the average number of affected organs, the high frequency of extrathoracic organ involvement, the frequent use of corticosteroids, and a mortality rate of 5.3%.

In conclusion, in our groups, statistically significant elevations of serum PSA levels were observed in women with clinical signs of hyperandrogenism. We found higher levels in ovarian and adrenal subtypes, whereas women without clinical hyperandrogenism or women with clinical hyperandrogenism and normal hormonal serum levels had lower PSA levels.Although more studies and wider sample groups are needed, it seems that PSA determination is a good clinical hyperandrogenism marker and could be used in the monitoring of anti-androgenic treatment.

Additional supporting data may be found in the supplementary information of this article.Data S1. Materials and methods Figure S1. Statistical analysis of PCNA-positive cell ratio in control and Wnt5a TG epidermis at P21 and P71. Figure S2. Skin biopsy staining at the morphogenesis stage and P28. Figure S3. Wnt5a is over-expressed in the epidermis under the control of human K14 promoter. Abstract: Merkel cell carcinoma is believed to be derived from Merkel cells after infection by Merkel cell polyomavirus (MCPyV) and other poorly understood events. Transcriptional profiling using cDNA microarrays was performed on cells from MCPynegative and MCPy-positive Merkel cell carcinomas and isolated normal Merkel cells. This microarray revealed numerous significantly upregulated genes and some downregulated genes. The extensive list of genes that were identified in these experiments provides a large body of potentially valuable information of Merkel cell carcinoma carcinogenesis and could represent a source of potential targets for cancer therapy. DOI