Comparative trial of fluconazole and amphotericin in the treatment of denture stomatitis

Bissell, V.; Felix, David H; Wray, D. Walter

doi:10.1016/0030-4220(93)90290-k

Cited by 49 publications

(57 citation statements)

References 21 publications

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“…7 Amphotericin (lozenges and cream) was reported as being equally as effective as fluconazole in one clinical trial of the treatment of denture stomatitis. 8 Both polyenes can cause gastrointestinal disturbances.…”

Section: Discussionmentioning

confidence: 99%

Patterns of antifungal prescribing in general dental practice

et al. 2004

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Objective To examine the current practice of antifungal prescribing by GDPs in the United Kingdom. Design A postal questionnaire circulated to a random selection of 400 dentists. Outcome measures The questionnaires were analysed and the responses expressed as absolute and relative frequencies. Results Responses to the questionnaire were received from 297 (74.3%) GDPs. Nystatin was the most popular choice of antifungal agent that GDPs would use, followed by miconazole, amphotericin B and fluconazole. The likelihood of use of miconazole was positively linked to recent date of graduation. Lack of knowledge regarding contraindications and problems with azole antibiotics was found in a significant minority of practitioners (36%). Conclusions The present study indicates that azole antifungal agents (especially miconazole) are becoming more widely used by GDPs, but that knowledge regarding potential problems with their use is suboptimal. Nystatin remains the most popular choice of antifungal agent.Much attention has been focused on the prescribing of antibiotics recently. Such interest has largely examined antibacterial prescribing but there has been less work examining antifungal prescribing. Given that there is increasing evidence of Candida species becoming resistant to some antifungal agents, particularly the azole group, 1 it is timely to examine the current prescribing habits in general dental practice.Lewis et al. 2 investigated the prescribing of antibiotics by general dental practitioners (GDPs) in the United Kingdom in 1987. Since that study, newer azole antifungals, namely fluconazole, have become available in general dental practice. However, the azoles, unlike the polyene antifungals, are absorbed from the gastrointestinal tract and thus have the potential for interactions with other drugs. They also have the potential to be hepatotoxic. Over the last few years four antifungal drugs in a number of formulations, have been available for GDPs to prescribe under NHS regulations. 3 Nysatin is available as pastilles, suspension and ointment for extra-oral use on the skin, while amphotericin is only available in lozenges and suspension for intra-oral use. Miconazole is available as an oral gel as well as an ointment and cream (combined with 1% hydrocortisone) for use on the skin. Fluconazole capsules and suspension are available for oral/systemic use.The aim of the present study was to establish the types and formulations of antifungal agents prescribed by a cross section of general dental practitioners during 1999/2000. We wanted to examine if prescribing habits were influenced by the time since graduation and the possession of postgraduate qualifications. Also, we wished to examine the awareness of practitioners regarding contraindications to, and problems with azole antifungals. MATERIALS AND METHODSThe postal addresses of dental practitioners were obtained from the 1999 UK Dental Register. An initial total of 400 practitioners were selected by choosing every 74th entry in the register. Each of these dentists ...

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Section: Discussionmentioning

confidence: 99%

Patterns of antifungal prescribing in general dental practice

et al. 2004

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“…Likewise, the comparison of amphotericin lozenges and topical cream with systemic fluconazole showed similar clinical response [21]. However, either uncommon or no side-effects occurred during the treatment with fluconazole and only one patient complained about nausea [21]. Thus, the administration of both topical and systemic antifungals showed positive results for DS treatment.…”

Section: Discussionmentioning

confidence: 78%

“…Also, these studies observed transient elevation of liver serum enzymes, hepatitis, adrenal cortex suppression, pruritus, rash, headache, dizziness, and somnolence [1,27]. Likewise, the comparison of amphotericin lozenges and topical cream with systemic fluconazole showed similar clinical response [21]. However, either uncommon or no side-effects occurred during the treatment with fluconazole and only one patient complained about nausea [21].…”

Section: Discussionmentioning

confidence: 98%

“…Systemic therapy has been prescribed for DS in cases not responding to topical agents or in cases with presence of systemic factors, such as immunosuppression or diabetes [35][36][37]. Generally, the dentists are concerned about prescribing systemic antifungals because of the risk of side effects.36 Conversely, in vivo studies reported the efficacy of systemic antifungals with minimal or no side effects to treat patients with DS through [1,21,25,38]. Interestingly, a Spanish study on drug choice for oral candidiasis demonstrated the strong predilection for topical drugs (miconazole and nystatin) by general dentists while the experts, including stomatologists frequently chosen systemic antifungals in the same cases [16].…”

Section: Discussionmentioning

confidence: 99%

“…The number was reduced to two articles after strictly applying the inclusion criteria [1,21]. Of the eight articles, one study was not written in English, the full text of 4 articles was not available [18,[22][23][24] and 6 articles did not fulfill the review subject (DS diagnosis and/or the comparison between topical and systemic antifungal protocols) [17,19,[22][23][24].…”

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Is Topical Antifungal the Appropriate First Choice for Denture Stomatitis?

Flores¹,

Souza²,

Gomes³

2017

Ann Clin Lab Res

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Phytotherapy in the management of denture stomatitis: A systematic review and meta‐analysis of randomized controlled trials

Shui

Lyu

et al. 2021

Phytotherapy Research

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Medicinal plant extracts are commonly applied for infectious diseases and are perceived as alternatives to conventional antimicrobial agents. We aimed to confirm the efficacy of phytotherapy for denture stomatitis compared with conventional therapies and placebo. A comprehensive literature search was conducted in Pubmed, Embase, Cochrane Library (CENTRAL), Scopus, and Web of Science, in addition to manual searching. Randomized controlled trials (RCTs) published in English, and studying the treatment of denture stomatitis with herbal medicines, were included. The outcome measures included the relief of clinical signs, reduced Candida colony counts, adverse effects, and patient satisfaction. Nineteen RCTs were included for a systematic review based on selection criteria. Two of them were analyzed using a random‐effects model. There was no difference in the relief of clinical signs (odds ratio (OR) = 0.96; 95% confidence interval (CI): 0.43–2.15) and microbiological improvement (OR = 1.74; 95% CI: 0.55–5.45) between propolis and miconazole. Most of the included studies showed that phytomedicines had fewer side effects and more patient satisfaction than antifungals or disinfectants. However, further RCTs with more standardly prepared herbal formulations are required to verify the clinical efficacy of phytotherapy as an alternative or adjunctive therapy for denture stomatitis.

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Comparative trial of fluconazole and amphotericin in the treatment of denture stomatitis

Cited by 49 publications

References 21 publications

Patterns of antifungal prescribing in general dental practice

Patterns of antifungal prescribing in general dental practice

Is Topical Antifungal the Appropriate First Choice for Denture Stomatitis?

Phytotherapy in the management of denture stomatitis: A systematic review and meta‐analysis of randomized controlled trials

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