Phytotherapy in the management of denture stomatitis: A systematic review and meta‐analysis of randomized controlled trials

Abstract

Medicinal plant extracts are commonly applied for infectious diseases and are perceived as alternatives to conventional antimicrobial agents. We aimed to confirm the efficacy of phytotherapy for denture stomatitis compared with conventional therapies and placebo. A comprehensive literature search was conducted in Pubmed, Embase, Cochrane Library (CENTRAL), Scopus, and Web of Science, in addition to manual searching. Randomized controlled trials (RCTs) published in English, and studying the treatment of denture stomatitis with herbal medicines, were included. The outcome measures included the relief of clinical signs, reduced Candida colony counts, adverse effects, and patient satisfaction. Nineteen RCTs were included for a systematic review based on selection criteria. Two of them were analyzed using a random‐effects model. There was no difference in the relief of clinical signs (odds ratio (OR) = 0.96; 95% confidence interval (CI): 0.43–2.15) and microbiological improvement (OR = 1.74; 95% CI: 0.55–5.45) between propolis and miconazole. Most of the included studies showed that phytomedicines had fewer side effects and more patient satisfaction than antifungals or disinfectants. However, further RCTs with more standardly prepared herbal formulations are required to verify the clinical efficacy of phytotherapy as an alternative or adjunctive therapy for denture stomatitis.

Effects of Brazilian green propolis glycolic solutions against bacterial biofilm on elastomers used in maxillofacial prostheses

“…Although there is evidence that propolis has been used since the time of Ancient Egypt, mainly to embalm bodies (Sforcin, 2016), recent studies have focused on the green propolis extract derived from Baccharis dracunculifolia (Azevedo et al, 2021;Miranda et al, 2019;Sforcin, 2016;Yamaga et al, 2021). This is due to its effectiveness in the treatment of oral conditions, including prosthetic stomatitis (Shui et al, 2021), and recently in the disinfection of complete dentures and maxillofacial prostheses (Capistrano et al, 2013;de Azevedo et al, 2021;de Souza et al, 2019;Miranda et al, 2019).…”

Antimicrobial effect of natural kinds of toothpaste on oral pathogenic bacteria

“…Secondary metabolites from plants, microorganisms and seafood have long been recognized as valuable sources of new molecules with drug development potential in many biomedical fields [13]. They show anti-inflammatory, analgesic [14], antimicrobial [15], antineoplastic [16] and anticariogenic [17] effects. The development and introduction of oral care products claiming to be prepared from natural agents has been continually increasing [18].…”

Fitoterapia no tratamento da candidíase oral: Um protocolo de revisão de escopo

“…A terapia fotodinâmica, a desinfecção por microoondas, o uso de soluções desinfetantes e o uso de produtos fitoterápicos têm sido sugeridos como alternativas aos antifúngicos (Emami, Kabawat, Rompre & Feine, 2014). Dentre estes, a fitoterapia tem se destacado devido à sua ação antimicrobiana e antiinflamatória, reações tóxicas Research, Society and Development, v. 10, n. 7, e35010716653, 2021 (CC BY 4.0) | ISSN 2525-3409 | DOI: http://dx.doi.org/10.33448/rsd-v10i7.16653 diminuídas, redução no desenvolvimento de cepas resistentes, alta biocompatibilidade e baixo custo, sendo considerada uma alternativa promissora no tratamento da candidíase oral e/ou estomatite protética (Ferreira et al, 2015;Gad & Fouda, 2020;Shui, Li, Lyu & Wang, 2021).…”

“…Uma revisão sistemática foi realizada há mais de seis anos (Ferreira et al, 2015), porém os autores encontraram grande heterogeneidade quanto ao delineamento dos estudos e aos produtos e posologias utilizados, demonstrando a ausência de evidência científica no tratamento da candidíase oral. Uma outra revisão sistemática (Shui et al, 2021) sobre a eficácia dos fitoterápicos no tratamento da estomatite protética concluiu que, embora o uso seja promissor, devido aos baixos efeitos adversos, são necessários mais ensaios clínicos randomizados para confirmar a sua eficácia como substitutos dos antifúngicos.…”