Comparative Ultrastructure of Soft-Tissue Myxoid Tumors

Vuzevski, VD; Ro, van der Heul

doi:10.3109/01913128809048478

Cited by 17 publications

(9 citation statements)

References 40 publications

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“…Additionally, the lipoblast-like cells stained with Alcian blue and lacked the osmophilic properties of a lipoblast. Silverman and Coalson [12] and Vuzevski [42] studied a myxoid MFH electron microscopically and described five cell types, similar to those seen in this case. No myfibroblast-like cells were seen in this case, as were described by Kindblom and coworkers [26].…”

Section: Discussionsupporting

confidence: 53%

“…The electron microscopic demonstration of fibroblast-like cells, histiocyte-like cells, intermediate cells, primitive appearing cells, and vacuolated cells aided in the diagnosis of this tumor, previously described as a lowgrade myxoid MFH. This combination of cells were at one time regarded as diagniostic for the diagnosis of a MFH [26,39,42,[50][51][52][53][54]. Suh et al [49] examined 32 cases of myxoid MFH's and found no evidence of true histiocytic differentiation in any, which led some authors to conclude that these are tumors of the fibroblast lineage [20].…”

Section: Discussionmentioning

confidence: 99%

“…The presence of curvilinear vessels and atypia ruled out benign fibrous lesions, which present with radiating vascular patterns and absence of atypia. Malignancies that were considered included myxoid liposarcoma [42], myxoid chondrosarcoma [26,42], myxoid leimyosarcoma [43], myxofibrosarcoma [44,45], myxoid neurogenic sarcoma [42], low-grade fibromyxoid sarcoma [46] and myxoid squamous carcinoma [47]. The lack of positive staining with a panel of monoclonal antibodies aided in excluding the myxoid neurogenic sarcoma, leimyosarcoma and myxoid squamous carcinoma.…”

Section: Discussionmentioning

confidence: 99%

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Myxofibrosarcoma Arising in the Maxillary Sinus: A Case Report with a Review of the Ultrastructural Findings and Differential Diagnoses

Norval

Raubenheimer

2011

J. Maxillofac. Oral Surg.

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This is a case report of a patient presenting with a destructive lesion with histologic features of a low grade malignancy in a predominantly myxoid matrix. Various low grade myxoid malignancies were considered in the differential diagnosis of which an overview is presented. A literature review of the ultrastructural findings and possible histogenesis is discussed along with the diagnostic criteria and recent change in the terminology regarding the malignancies previously diagnosed as myxoid malignant fibrous histiocytomas. A final diagnosis of a myxofibrosarcoma was only possible after assessing the immuno-histochemical profile, results of histochemical stains and ultrastructural features of this lesion.

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Section: Discussionsupporting

confidence: 53%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Myxofibrosarcoma Arising in the Maxillary Sinus: A Case Report with a Review of the Ultrastructural Findings and Differential Diagnoses

Norval

Raubenheimer

2011

J. Maxillofac. Oral Surg.

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“…These aspects are less distinctive as compared to the typical storiform pattern of CDFSP (1,2). Consequently, a careful differential diagnosis from other benign or malignant myxoid tumors involving the skin must be studied (10), especially when small biopsies are summitted for pathologic examination. The absence of lipoblasts.…”

Section: Discussionmentioning

confidence: 99%

Myxoid dermatofibrosarcoma protuberans: morphological, ultrastructural and immunohistochemical features

1998

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Two uncommon cases of dermatofibrosarcoma protuberans with prominent myxoid changes are presented. The tumors appeared as large multinodular cutaneous plaques that arose at the sites of excision of previous tumors some years earlier. In addition to limited fibrous storiform features, focally observed in deep and peripheral portions of the tumors, a diffuse myxoid pattern could be observed. The latter consisted of homogeneous areas of rare, stellate or spindle-shaped cells, haphazardly scattered in abundant myxoid matrix. Cells of myxoid neoplastic tissue showed mainly a positive immunoreaction for fibrohistocytic markers and the absence either of muscular, neural or human progenitor cell antigens. Mitotic figures were fewer and cell proliferation rates were lower in myxoid as compared to those of typical dermatofibrosarcoma protuberans used as a control. The ultrastructural examination of myxoid areas revealed a prevalent fibroblast-like cell population showing dilated cytoplasmic vesicles, sometimes containing glycosaminoglycans-like substances. The extent of myxoid changes together with the characteristic morphological, ultrastructural and immunohistochemical features confirm that myxoid dermatofibrosarcoma protuberans is a distinct variant of this fibrohistiocytic tumor to be considered in the differential diagnosis among myxoid tumors of the skin.

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“…24 Histologically, the typical findings include nodularity, arrangement of tumor cells in cords, strands, and nests, hypercellularity along the periphery of the nodules, and a chondroid / myxoid stroma. 24,25 The presumed origin of the tumor is cartilage, 27,28 and thus of mesodermal origin when it occurs in locations other than the head and neck. S-100 immunoreactivity in cartilaginous neoplasms such as ESMC has been attributed to the chondroid nature and hence mesodermal derivation of the cells, and ultrastructural studies have supported a chondroid origin of these tumors.…”

Section: Discussionmentioning

confidence: 99%

Expression of the intermediate filament peripherin in extraskeletal myxoid chondrosarcoma

et al. 2000

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The embryologic histogenesis of cartilage is not well characterized. While cranial cartilage is believed to be derived from pluripotential precursor cells of the neural crest, chondrocytes found elsewhere in the body are thought to be derived from mesoderm. As such, soft tissue tumors with cartilaginous differentiation may be related to neural crest or mesoderm. Peripherin is an intermediate filament encoded on chromosome 12, involved in growth and development of the peripheral nervous system. Peripherin is apparently expressed exclusively in cells derived from the neural crest and neural tube. A group of six soft tissue tumor types was selected because they are either of controversial differentiation or cytogenetically related to chromosome 12. A total of 41 cases was evaluated with antibodies against the intermediate filament peripherin. A panel of neural and neuroendocrine differentiation markers was used in selected cases. Three of five extraskeletal myxoid chondrosarcomas showed strong cytoplasmic reactivity with anti-peripherin. No peripherin expression was noted in any of eleven epithelioid sarcomas, eight liposarcomas, seven conventional chondrosarcomas, four neurothekeomas, three alveolar soft part sarcomas, or three clear cell sarcomas. The finding of peripherin expression in some extraskeletal myxoid chondrosarcomas may suggest the ability of some tumors to demonstrate both neural and chondroid differentiation.

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Comparative Ultrastructure of Soft-Tissue Myxoid Tumors

Cited by 17 publications

References 40 publications

Myxofibrosarcoma Arising in the Maxillary Sinus: A Case Report with a Review of the Ultrastructural Findings and Differential Diagnoses

Myxofibrosarcoma Arising in the Maxillary Sinus: A Case Report with a Review of the Ultrastructural Findings and Differential Diagnoses

Myxoid dermatofibrosarcoma protuberans: morphological, ultrastructural and immunohistochemical features

Expression of the intermediate filament peripherin in extraskeletal myxoid chondrosarcoma

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